FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2589056186> ?p ?o ?g. }

• W2589056186 endingPage "926" @default.
• W2589056186 startingPage "918" @default.
• W2589056186 abstract "Epidermolysis bullosa acquisita (EBA) is a difficult-to-treat subepidermal autoimmune blistering skin disease (AIBD) with circulating and tissue-bound anti-type VII collagen antibodies. Different reports have indicated increased concentration of tumor necrosis factor α (TNF) in the serum and blister fluid of patients with subepidermal AIBD. Furthermore, successful anti-TNF treatment has been reported for individual patients with AIBD. Here we show that in mice, induction of experimental EBA by repeated injections of rabbit anti-mouse type VII collagen antibodies led to increased expression of TNF in skin, as determined by real-time polymerase chain reaction (PCR) and immunohistochemistry. To investigate whether the increased TNF expression is of functional relevance in experimental EBA, we inhibited TNF function using the soluble TNF receptor fusion protein etanercept (Enbrel) or a monoclonal antibody to murine TNF. Interestingly, mice that received either of these treatments showed significantly milder disease progression than controls. In addition, immunohistochemical staining demonstrated reduced numbers of macrophages in lesional skin in mice treated with TNF inhibitors compared with controls. Furthermore, etanercept treatment significantly reduced disease progression in immunization-induced EBA. In conclusion, increased expression of TNF in experimental EBA is of functional relevance, as both the prophylactic blockade of TNF and the therapeutic use of etanercept impaired induction and progression of experimental EBA. Thus, TNF is likely to serve as a new therapeutic target for EBA and AIBDs with a similar pathogenesis." @default.
• W2589056186 created "2017-02-24" @default.
• W2589056186 creator A5006462331 @default.
• W2589056186 creator A5008846661 @default.
• W2589056186 creator A5021559096 @default.
• W2589056186 creator A5033649059 @default.
• W2589056186 creator A5033679659 @default.
• W2589056186 creator A5040445880 @default.
• W2589056186 creator A5055255076 @default.
• W2589056186 creator A5057143146 @default.
• W2589056186 creator A5064946909 @default.
• W2589056186 creator A5067198663 @default.
• W2589056186 creator A5075201374 @default.
• W2589056186 creator A5083484570 @default.
• W2589056186 creator A5090163750 @default.
• W2589056186 creator A5090549024 @default.
• W2589056186 date "2016-01-01" @default.
• W2589056186 modified "2023-10-14" @default.
• W2589056186 title "Reduced Skin Blistering in Experimental Epidermolysis Bullosa Acquisita After Anti-TNF Treatment" @default.
• W2589056186 cites W117506941 @default.
• W2589056186 cites W150052686 @default.
• W2589056186 cites W1504831028 @default.
• W2589056186 cites W1557346014 @default.
• W2589056186 cites W1600316569 @default.
• W2589056186 cites W1836480642 @default.
• W2589056186 cites W1912288378 @default.
• W2589056186 cites W1964469958 @default.
• W2589056186 cites W1985047670 @default.
• W2589056186 cites W1989395082 @default.
• W2589056186 cites W1996250489 @default.
• W2589056186 cites W1999905091 @default.
• W2589056186 cites W200535253 @default.
• W2589056186 cites W2015598465 @default.
• W2589056186 cites W2017349100 @default.
• W2589056186 cites W2017374678 @default.
• W2589056186 cites W2028174725 @default.
• W2589056186 cites W2031680195 @default.
• W2589056186 cites W2038322465 @default.
• W2589056186 cites W2039671281 @default.
• W2589056186 cites W2039976430 @default.
• W2589056186 cites W2049827204 @default.
• W2589056186 cites W2053889157 @default.
• W2589056186 cites W2057123987 @default.
• W2589056186 cites W2080890577 @default.
• W2589056186 cites W2081963649 @default.
• W2589056186 cites W2084180208 @default.
• W2589056186 cites W2086721113 @default.
• W2589056186 cites W2089216091 @default.
• W2589056186 cites W2090298126 @default.
• W2589056186 cites W2094066663 @default.
• W2589056186 cites W2094778049 @default.
• W2589056186 cites W2096533272 @default.
• W2589056186 cites W2097207838 @default.
• W2589056186 cites W2102143428 @default.
• W2589056186 cites W2104902789 @default.
• W2589056186 cites W2111913995 @default.
• W2589056186 cites W2118151585 @default.
• W2589056186 cites W2122864852 @default.
• W2589056186 cites W2126342903 @default.
• W2589056186 cites W2130594874 @default.
• W2589056186 cites W2139935948 @default.
• W2589056186 cites W2150318509 @default.
• W2589056186 cites W2152335168 @default.
• W2589056186 cites W2156351184 @default.
• W2589056186 cites W2167900741 @default.
• W2589056186 cites W2228797053 @default.
• W2589056186 cites W2265991669 @default.
• W2589056186 cites W2332129675 @default.
• W2589056186 cites W2413170799 @default.
• W2589056186 cites W3021825977 @default.
• W2589056186 cites W4240127769 @default.
• W2589056186 cites W4243974294 @default.
• W2589056186 cites W194360217 @default.
• W2589056186 doi "https://doi.org/10.2119/molmed.2015.00206" @default.
• W2589056186 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5319204" @default.
• W2589056186 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27999842" @default.
• W2589056186 hasPublicationYear "2016" @default.
• W2589056186 type Work @default.
• W2589056186 sameAs 2589056186 @default.
• W2589056186 citedByCount "25" @default.
• W2589056186 countsByYear W25890561862017 @default.
• W2589056186 countsByYear W25890561862018 @default.
• W2589056186 countsByYear W25890561862019 @default.
• W2589056186 countsByYear W25890561862020 @default.
• W2589056186 countsByYear W25890561862021 @default.
• W2589056186 countsByYear W25890561862022 @default.
• W2589056186 countsByYear W25890561862023 @default.
• W2589056186 crossrefType "journal-article" @default.
• W2589056186 hasAuthorship W2589056186A5006462331 @default.
• W2589056186 hasAuthorship W2589056186A5008846661 @default.
• W2589056186 hasAuthorship W2589056186A5021559096 @default.
• W2589056186 hasAuthorship W2589056186A5033649059 @default.
• W2589056186 hasAuthorship W2589056186A5033679659 @default.
• W2589056186 hasAuthorship W2589056186A5040445880 @default.
• W2589056186 hasAuthorship W2589056186A5055255076 @default.
• W2589056186 hasAuthorship W2589056186A5057143146 @default.
• W2589056186 hasAuthorship W2589056186A5064946909 @default.
• W2589056186 hasAuthorship W2589056186A5067198663 @default.

• next