FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2589063450> ?p ?o ?g. }

• W2589063450 endingPage "275" @default.
• W2589063450 startingPage "275" @default.
• W2589063450 abstract "In their paper on combined pre- and post-capillary pulmonary hypertension, Assad et al. say that “the resistance-compliance (RC) time has emerged as a measure of pulmonary vascular physiology that integrates the mean and pulsatile afterload of the right ventricle.”1 They discuss reports in the literature of changes in RC time in a variety of conditions. The findings in their study show that “the RC times in combined post-capillary and pre-capillary pulmonary hypertension and in pulmonary arterial hypertension were nearly the same, and both were almost twice as high as that in isolated post-capillary pulmonary hypertension.”1 However, the nearly 2000 patients without pulmonary hypertension demonstrated that a “normal” RC time lies somewhere in-between. We consider that this shows that the RC time does not integrate the mean and pulsatile afterloads of the right ventricle. Indeed, as pulmonary hypertension worsens, the components of RC time go in opposite directions: pulmonary vascular resistance (PVR) increases, while pulmonary vascular compliance (PVC) decreases. Consequently, one offsets the other in the term, RC time. For the clinician trying to describe the severity of the afterload to right ventricular ejection, would it not make more sense to calculate the PVR times the reciprocal of the compliance (1/PVC). This (resistance over compliance; ROC) would increase steadily as the pulmonary hypertension worsens and would be more intuitive. To illustrate this, we calculated the RC time and ROC for the four groups of patients described by Assad et al.: controls, isolated post-capillary pulmonary hypertension, combined post-capillary and pre-capillary pulmonary hypertension, and pulmonary arterial hypertension.1 We used the mean PVR and PVC of the groups to compute the RC time and ROC as we did not have the individual patient level data. The ROC increased linearly as the severity of pulmonary hypertension increased from the control group to patients with isolated post-capillary pulmonary hypertension, combined post-capillary and pre-capillary pulmonary hypertension, and pulmonary arterial hypertension (Fig. 1). Comparison of RC vs. ROC in different forms and severities of pulmonary hypertension. These are patients who underwent right heart catheterization from 1998 to 2014 at Vanderbilt University and were in Vanderbilt’s Synthetic Derivative database.1 Controls are patients with no pulmonary hypertension. CpcPH, combined post-capillary and pre-capillary pulmonary hypertension; IpcPH, isolated post-capillary pulmonary hypertension; PAH, pulmonary arterial hypertension; RC, resistance-compliance time; ROC, resistance over compliance." @default.
• W2589063450 created "2017-02-24" @default.
• W2589063450 creator A5023499622 @default.
• W2589063450 creator A5054612339 @default.
• W2589063450 creator A5083044879 @default.
• W2589063450 date "2016-12-01" @default.
• W2589063450 modified "2023-09-24" @default.
• W2589063450 title "Resistance over compliance describes right ventricular afterload better than resistance-compliance time: a friendly amendment" @default.
• W2589063450 cites W2465698549 @default.
• W2589063450 doi "https://doi.org/10.1177/2045893216681025" @default.
• W2589063450 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5448527" @default.
• W2589063450 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28680587" @default.
• W2589063450 hasPublicationYear "2016" @default.
• W2589063450 type Work @default.
• W2589063450 sameAs 2589063450 @default.
• W2589063450 citedByCount "0" @default.
• W2589063450 crossrefType "journal-article" @default.
• W2589063450 hasAuthorship W2589063450A5023499622 @default.
• W2589063450 hasAuthorship W2589063450A5054612339 @default.
• W2589063450 hasAuthorship W2589063450A5083044879 @default.
• W2589063450 hasBestOaLocation W25890634501 @default.
• W2589063450 hasConcept C123576724 @default.
• W2589063450 hasConcept C126322002 @default.
• W2589063450 hasConcept C15744967 @default.
• W2589063450 hasConcept C164705383 @default.
• W2589063450 hasConcept C178853913 @default.
• W2589063450 hasConcept C2778921608 @default.
• W2589063450 hasConcept C2780930700 @default.
• W2589063450 hasConcept C2781460075 @default.
• W2589063450 hasConcept C58245268 @default.
• W2589063450 hasConcept C71924100 @default.
• W2589063450 hasConcept C77805123 @default.
• W2589063450 hasConcept C79191276 @default.
• W2589063450 hasConceptScore W2589063450C123576724 @default.
• W2589063450 hasConceptScore W2589063450C126322002 @default.
• W2589063450 hasConceptScore W2589063450C15744967 @default.
• W2589063450 hasConceptScore W2589063450C164705383 @default.
• W2589063450 hasConceptScore W2589063450C178853913 @default.
• W2589063450 hasConceptScore W2589063450C2778921608 @default.
• W2589063450 hasConceptScore W2589063450C2780930700 @default.
• W2589063450 hasConceptScore W2589063450C2781460075 @default.
• W2589063450 hasConceptScore W2589063450C58245268 @default.
• W2589063450 hasConceptScore W2589063450C71924100 @default.
• W2589063450 hasConceptScore W2589063450C77805123 @default.
• W2589063450 hasConceptScore W2589063450C79191276 @default.
• W2589063450 hasIssue "1" @default.
• W2589063450 hasLocation W25890634501 @default.
• W2589063450 hasLocation W25890634502 @default.
• W2589063450 hasLocation W25890634503 @default.
• W2589063450 hasLocation W25890634504 @default.
• W2589063450 hasOpenAccess W2589063450 @default.
• W2589063450 hasPrimaryLocation W25890634501 @default.
• W2589063450 hasRelatedWork W162863481 @default.
• W2589063450 hasRelatedWork W1990754594 @default.
• W2589063450 hasRelatedWork W2110084174 @default.
• W2589063450 hasRelatedWork W2168807618 @default.
• W2589063450 hasRelatedWork W2170749073 @default.
• W2589063450 hasRelatedWork W2283619910 @default.
• W2589063450 hasRelatedWork W2435105191 @default.
• W2589063450 hasRelatedWork W2752352806 @default.
• W2589063450 hasRelatedWork W2785910744 @default.
• W2589063450 hasRelatedWork W4323807072 @default.
• W2589063450 hasVolume "7" @default.
• W2589063450 isParatext "false" @default.
• W2589063450 isRetracted "false" @default.
• W2589063450 magId "2589063450" @default.
• W2589063450 workType "article" @default.