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- W2589078924 abstract "[C20H17N3O2] and cobalt (II) complex [Co(L2)(MeOH)2].ClO4, (L2 = 4-((E)-1-((2-(((E)-pyridin-2-ylmethylene) amino) phenyl) imino) ethyl) benzene-1, 3-diol) novel Schiff base has been synthesiszed and chracterized by Fourier transform infrared, UV-vis, 1H-NMR spectroscopy, and elemental analysis techniques. The interaction of Co(II) complex with DNA and BSA was investigated by electronic absorption spectroscopy, fluorescence spectroscopy, circular dichroism, and thermal denaturation studies. Our experiments indicate that this complex could strongly bind to CT-DNA via minor groove mechanism. In addition, fluorescence spectrometry of BSA with the complex showed that the fluorescence quenching mechanism of BSA was of static type. The complex exhibited significant in vitro cytotoxicity against three human cancer cell lines (JURKAT, SKOV3, and U87). The molecular docking experiment effectively proved the binding of complex to DNA and BSA. Finally, antibacterial assay over gram-positive and gram-negative pathogenic bacterial strains was studied." @default.
- W2589078924 created "2017-02-24" @default.
- W2589078924 creator A5006330413 @default.
- W2589078924 creator A5014997372 @default.
- W2589078924 creator A5019467887 @default.
- W2589078924 creator A5020153911 @default.
- W2589078924 creator A5078323524 @default.
- W2589078924 date "2017-03-08" @default.
- W2589078924 modified "2023-10-17" @default.
- W2589078924 title "Cobalt (II) complex with novel unsymmetrical tetradentate Schiff base (ON) ligand: <i>in vitro</i> cytotoxicity studies of complex, interaction with DNA/protein, molecular docking studies, and antibacterial activity" @default.
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