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- W2589088788 endingPage "1239" @default.
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- W2589088788 abstract "Introduction: Local myocardial delivery (LMD) of therapeutic agents is a promising strategy that aims to treat various myocardial pathologies. It is designed to deliver agents directly to the myocardium and minimize their extracardiac concentrations and side effects. LMD aims to enhance outcomes of existing therapies by broadening their therapeutic window and to utilize new agents that could not be otherwise be implemented systemically.Areas covered: This article provides a historical overview of six decades LMD evolution in terms of the approaches, including intrapericardial, epicardial, and intramyocardial delivery, and the wide array of classes of agents used to treat myocardial pathologies. We examines delivery of pharmaceutical compounds, targeted gene transfection and cell implantation techniques to produce therapeutic effects locally. We outline therapeutic indications, successes and failures as well as technical approaches for LMD.Expert opinion: While LMD is more complicated than conventional oral or intravenous administration, given recent advances in interventional cardiology, it is safe and may provide better therapeutic outcomes. LMD is complex as many factors impact pharmacokinetics and biologic result. The choice between routes of LMD is largely driven not only by the myocardial pathology but also by the nature and physicochemical properties of the therapeutic agents." @default.
- W2589088788 created "2017-02-24" @default.
- W2589088788 creator A5036622392 @default.
- W2589088788 creator A5038170950 @default.
- W2589088788 creator A5053071754 @default.
- W2589088788 date "2017-02-22" @default.
- W2589088788 modified "2023-10-17" @default.
- W2589088788 title "Delivery of drugs, growth factors, genes and stem cells via intrapericardial, epicardial and intramyocardial routes for sustained local targeted therapy of myocardial disease" @default.
- W2589088788 cites W1541887683 @default.
- W2589088788 cites W1608456701 @default.
- W2589088788 cites W1631250427 @default.
- W2589088788 cites W1661453118 @default.
- W2589088788 cites W1935869030 @default.
- W2589088788 cites W1964058577 @default.
- W2589088788 cites W1966668911 @default.
- W2589088788 cites W1967748130 @default.
- W2589088788 cites W1967843439 @default.
- W2589088788 cites W1968278388 @default.
- W2589088788 cites W1969029299 @default.
- W2589088788 cites W1970538429 @default.
- W2589088788 cites W1971218073 @default.
- W2589088788 cites W1972221671 @default.
- W2589088788 cites W1973316598 @default.
- W2589088788 cites W1973892420 @default.
- W2589088788 cites W1975485136 @default.
- W2589088788 cites W1975997387 @default.
- W2589088788 cites W1976514247 @default.
- W2589088788 cites W1977158361 @default.
- W2589088788 cites W1977413720 @default.
- W2589088788 cites W1977624384 @default.
- W2589088788 cites W1977872287 @default.
- W2589088788 cites W1980179169 @default.
- W2589088788 cites W1980471642 @default.
- W2589088788 cites W1982688102 @default.
- W2589088788 cites W1982743855 @default.
- W2589088788 cites W1984923170 @default.
- W2589088788 cites W1986123592 @default.
- W2589088788 cites W1986380083 @default.
- W2589088788 cites W1989934556 @default.
- W2589088788 cites W1991235312 @default.
- W2589088788 cites W1992292208 @default.
- W2589088788 cites W1992638959 @default.
- W2589088788 cites W1995270760 @default.
- W2589088788 cites W1997616176 @default.
- W2589088788 cites W1999256227 @default.
- W2589088788 cites W2003996125 @default.
- W2589088788 cites W2005820540 @default.
- W2589088788 cites W2011845294 @default.
- W2589088788 cites W2013381213 @default.
- W2589088788 cites W2015283592 @default.
- W2589088788 cites W2015792739 @default.
- W2589088788 cites W2016273702 @default.
- W2589088788 cites W201711400 @default.
- W2589088788 cites W2019604222 @default.
- W2589088788 cites W2026372414 @default.
- W2589088788 cites W2029733946 @default.
- W2589088788 cites W2029872197 @default.
- W2589088788 cites W2035281021 @default.
- W2589088788 cites W2037879116 @default.
- W2589088788 cites W2038336740 @default.
- W2589088788 cites W2039314779 @default.
- W2589088788 cites W2043004777 @default.
- W2589088788 cites W2043852940 @default.
- W2589088788 cites W2046067234 @default.
- W2589088788 cites W2046253273 @default.
- W2589088788 cites W2049427543 @default.
- W2589088788 cites W2050329756 @default.
- W2589088788 cites W2050392216 @default.
- W2589088788 cites W2050974735 @default.
- W2589088788 cites W2051202081 @default.
- W2589088788 cites W2054847560 @default.
- W2589088788 cites W2058762168 @default.
- W2589088788 cites W2059644490 @default.
- W2589088788 cites W2061285177 @default.
- W2589088788 cites W2064125786 @default.
- W2589088788 cites W2065507080 @default.
- W2589088788 cites W2065608118 @default.
- W2589088788 cites W2066137787 @default.
- W2589088788 cites W2068184354 @default.
- W2589088788 cites W2069763537 @default.
- W2589088788 cites W2069909147 @default.
- W2589088788 cites W2074259561 @default.
- W2589088788 cites W2074517267 @default.
- W2589088788 cites W2074758042 @default.
- W2589088788 cites W2075344844 @default.
- W2589088788 cites W2080344183 @default.
- W2589088788 cites W2081498718 @default.
- W2589088788 cites W2083275040 @default.
- W2589088788 cites W2084231772 @default.
- W2589088788 cites W2084452008 @default.
- W2589088788 cites W2084958759 @default.
- W2589088788 cites W2085448902 @default.
- W2589088788 cites W2089000873 @default.
- W2589088788 cites W2089929916 @default.
- W2589088788 cites W2089991723 @default.
- W2589088788 cites W2090068113 @default.
- W2589088788 cites W2091963228 @default.
- W2589088788 cites W2092077170 @default.