FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2589100736> ?p ?o ?g. }

• W2589100736 endingPage "572" @default.
• W2589100736 startingPage "553" @default.
• W2589100736 abstract "The present study aimed to investigate the protective and therapeutic effects of caffeine on rotenone-induced rat model of Parkinson's disease (PD). Rats were divided into control, PD model induced by rotenone (1.5 mg/kg intraperitoneally (i.p.) for 45 days), protected group injected with caffeine (30 mg/kg, i.p.) and rotenone for 45 days (during the development of PD model), and treated group injected with caffeine (30 mg/kg, i.p.) for 45 days after induction of PD model. The data revealed a state of oxidative and nitrosative stress in the midbrain and the striatum of animal model of PD as indicated from the increased lipid peroxidation and nitric oxide levels and the decreased reduced glutathione level and activities of glutathione-S-transferase and superoxide dismutase. Rotenone induced a decrease in acetylcholinesterase and Na+/K+-ATPase activities and an increase in tumor necrosis factor-α level in the midbrain and the striatum. Protection and treatment with caffeine ameliorated the oxidative stress and the changes in acetylcholinesterase and Na+/K+-ATPase activities induced by rotenone in the midbrain and the striatum. This was associated with improvement in the histopathological changes induced in the two areas of PD model. Caffeine protection and treatment restored the depletion of midbrain and striatal dopamine induced by rotenone and prevented decline in motor activities (assessed by open field test) and muscular strength (assessed by traction and hanging tests) and improved norepinephrine level in the two areas. The present study showed that caffeine offered a significant neuroprotection and treatment against neurochemical, histopathological, and behavioral changes in a rotenone-induced rat model of PD." @default.
• W2589100736 created "2017-02-24" @default.
• W2589100736 creator A5017091015 @default.
• W2589100736 creator A5027814734 @default.
• W2589100736 creator A5038637267 @default.
• W2589100736 creator A5056825580 @default.
• W2589100736 creator A5071076816 @default.
• W2589100736 creator A5071916476 @default.
• W2589100736 date "2017-02-13" @default.
• W2589100736 modified "2023-10-01" @default.
• W2589100736 title "Neuroprotective and Therapeutic Effect of Caffeine on the Rat Model of Parkinson's Disease Induced by Rotenone" @default.
• W2589100736 cites W1503230255 @default.
• W2589100736 cites W1504584187 @default.
• W2589100736 cites W1515108121 @default.
• W2589100736 cites W1530782517 @default.
• W2589100736 cites W1535874369 @default.
• W2589100736 cites W1542142828 @default.
• W2589100736 cites W1577751913 @default.
• W2589100736 cites W1968296463 @default.
• W2589100736 cites W1971048984 @default.
• W2589100736 cites W1974090212 @default.
• W2589100736 cites W1977138583 @default.
• W2589100736 cites W1978186008 @default.
• W2589100736 cites W1978412429 @default.
• W2589100736 cites W1986219537 @default.
• W2589100736 cites W1991775006 @default.
• W2589100736 cites W1991863073 @default.
• W2589100736 cites W1993066818 @default.
• W2589100736 cites W1994970739 @default.
• W2589100736 cites W1998294404 @default.
• W2589100736 cites W1998660833 @default.
• W2589100736 cites W2000444665 @default.
• W2589100736 cites W2002792886 @default.
• W2589100736 cites W2003598937 @default.
• W2589100736 cites W2006571572 @default.
• W2589100736 cites W2011981175 @default.
• W2589100736 cites W2012992792 @default.
• W2589100736 cites W2013139563 @default.
• W2589100736 cites W2022599378 @default.
• W2589100736 cites W2023796931 @default.
• W2589100736 cites W2025995690 @default.
• W2589100736 cites W2029549580 @default.
• W2589100736 cites W2031323872 @default.
• W2589100736 cites W2031875947 @default.
• W2589100736 cites W2033564079 @default.
• W2589100736 cites W2036554135 @default.
• W2589100736 cites W2038205497 @default.
• W2589100736 cites W2043290296 @default.
• W2589100736 cites W2046033957 @default.
• W2589100736 cites W2046801007 @default.
• W2589100736 cites W2051768564 @default.
• W2589100736 cites W2059044475 @default.
• W2589100736 cites W2060208018 @default.
• W2589100736 cites W2062781235 @default.
• W2589100736 cites W2073449985 @default.
• W2589100736 cites W2077541721 @default.
• W2589100736 cites W2081412929 @default.
• W2589100736 cites W2092956702 @default.
• W2589100736 cites W2100108410 @default.
• W2589100736 cites W2103633814 @default.
• W2589100736 cites W2104954371 @default.
• W2589100736 cites W2112288676 @default.
• W2589100736 cites W2115485956 @default.
• W2589100736 cites W2122468487 @default.
• W2589100736 cites W2130570136 @default.
• W2589100736 cites W2147521090 @default.
• W2589100736 cites W2150792183 @default.
• W2589100736 cites W4296025734 @default.
• W2589100736 cites W62603772 @default.
• W2589100736 cites W2332537023 @default.
• W2589100736 doi "https://doi.org/10.1080/19390211.2016.1275916" @default.
• W2589100736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28301304" @default.
• W2589100736 hasPublicationYear "2017" @default.
• W2589100736 type Work @default.
• W2589100736 sameAs 2589100736 @default.
• W2589100736 citedByCount "62" @default.
• W2589100736 countsByYear W25891007362018 @default.
• W2589100736 countsByYear W25891007362019 @default.
• W2589100736 countsByYear W25891007362020 @default.
• W2589100736 countsByYear W25891007362021 @default.
• W2589100736 countsByYear W25891007362022 @default.
• W2589100736 countsByYear W25891007362023 @default.
• W2589100736 crossrefType "journal-article" @default.
• W2589100736 hasAuthorship W2589100736A5017091015 @default.
• W2589100736 hasAuthorship W2589100736A5027814734 @default.
• W2589100736 hasAuthorship W2589100736A5038637267 @default.
• W2589100736 hasAuthorship W2589100736A5056825580 @default.
• W2589100736 hasAuthorship W2589100736A5071076816 @default.
• W2589100736 hasAuthorship W2589100736A5071916476 @default.
• W2589100736 hasConcept C126322002 @default.
• W2589100736 hasConcept C134018914 @default.
• W2589100736 hasConcept C181199279 @default.
• W2589100736 hasConcept C185592680 @default.
• W2589100736 hasConcept C25498285 @default.
• W2589100736 hasConcept C2775838275 @default.
• W2589100736 hasConcept C2776151105 @default.
• W2589100736 hasConcept C2778389096 @default.
• W2589100736 hasConcept C2778500429 @default.

• next