Matches in SemOpenAlex for { <https://semopenalex.org/work/W2589139101> ?p ?o ?g. }
- W2589139101 endingPage "32291" @default.
- W2589139101 startingPage "32270" @default.
- W2589139101 abstract "// Zackie Aktary 1,2,* , Mahsa Alaee 1,* and Manijeh Pasdar 1 1 Department of Oncology, University of Alberta, Edmonton, Alberta, Canada 2 Institut Curie, Orsay, France * These authors have contributed equally to this study Correspondence to: Manijeh Pasdar, email: // Keywords : Plakoglobin, γ-catenin, tumor/metastasis suppressor, p53, gene expression Received : October 28, 2016 Accepted : December 16, 2016 Published : February 23, 2017 Abstract Plakoglobin (also known as γ-catenin) is a member of the Armadillo family of proteins and a paralog of β-catenin. Plakoglobin is a component of both the adherens junctions and desmosomes, and therefore plays a vital role in the regulation of cell-cell adhesion. Similar to β-catenin, plakoglobin is capable of participating in cell signaling in addition to its role in cell-cell adhesion. In this context, β-catenin has a well-documented oncogenic potential as a component of the Wnt signaling pathway. In contrast, while some studies have suggested a tumor promoting activity of plakoglobin in a cell/malignancy specific context, it generally acts as a tumor/metastasis suppressor. How plakoglobin acts as a growth/metastasis inhibitory protein has remained, until recently, unclear. Recent evidence suggests that plakoglobin may suppress tumorigenesis and metastasis by multiple mechanisms, including the suppression of oncogenic signaling, interactions with various proteins involved in tumorigenesis and metastasis, and the regulation of the expression of genes involved in these processes. This review is primarily focused on various mechanisms by which plakoglobin may inhibit tumorigenesis and metastasis." @default.
- W2589139101 created "2017-03-03" @default.
- W2589139101 creator A5002424124 @default.
- W2589139101 creator A5028824170 @default.
- W2589139101 creator A5036842109 @default.
- W2589139101 date "2017-02-23" @default.
- W2589139101 modified "2023-10-15" @default.
- W2589139101 title "Beyond cell-cell adhesion: Plakoglobin and the regulation of tumorigenesis and metastasis" @default.
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