FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2589220110> ?p ?o ?g. }

• W2589220110 abstract "Objective: to find out if the failure in immunotolerance of Myasthenia Gravis (MG) is a possible aspect of deduction in Breg cells and to characterize B cell subsets in MG. Methods: flow cytometry detection and ELISA assays in peripheral blood films of 10 MG patients and 10 healthy controls (HCs) were performed after isolation of B cells. The CD19+CD5+CD1d+ Breg cells percentages were measured to complement a B cell phenotype assay and frequencies of B cell subsets. The clinical outcome measures and immunological variables of patients with MG were compared with HCs. Results: patients with MG had relatively lowered percentages of CD19+CD5+CD1d+ Breg cells as compared to HCs. The production of Interleukin (IL) -10 and Transforming Growth Factor (TGF) -β1 was relatively lesser in patients with MG than HCs which were linked with more severe of MG disease status according to Myasthenia Gravis Foundation of America (MGFA) clinical classification. The reduction of cytokine production was more significant for IL-10 than TGF-β1 when compared to HCs. Conclusion: it has been observed that the reduced number of B cells are able to produce IL-10 in MG patients but lesser than compared to HCs. The Bregs reduction mainly was regarded by the severity of disease status which was highly significant and also by disease duration which was statistically significant as well. The findings of the measurement of B cell phenotype assay and frequencies of B cell subsets between MGs and HCs give us new ideas to develop B-cell mediated therapies of MG such as ① isolated B cells of MGs could be cultured with steroids eg. dexamethasone in vitro to see if it induces the CD19+CD5+CD1d+ Breg cells. ② it may observe whether induced CD19+CD5+CD1d+ Bregs have higher production of IL-10 and TGF-β1, as both are linked with disease severity. ③ after completion in vitro steps, through further research in vivo to observe whether it improves the function of MG disease status." @default.
• W2589220110 created "2017-03-03" @default.
• W2589220110 creator A5008739295 @default.
• W2589220110 creator A5030708251 @default.
• W2589220110 creator A5035428274 @default.
• W2589220110 creator A5045412256 @default.
• W2589220110 creator A5081570477 @default.
• W2589220110 date "2017-02-20" @default.
• W2589220110 modified "2023-10-03" @default.
• W2589220110 title "Regulatory B Cells in Seropositive Myasthenia Gravis versus Healthy Controls" @default.
• W2589220110 cites W1503016118 @default.
• W2589220110 cites W1512851684 @default.
• W2589220110 cites W1568142966 @default.
• W2589220110 cites W1607030948 @default.
• W2589220110 cites W1731046649 @default.
• W2589220110 cites W1868211256 @default.
• W2589220110 cites W1935840505 @default.
• W2589220110 cites W1938633852 @default.
• W2589220110 cites W1970742017 @default.
• W2589220110 cites W1971286997 @default.
• W2589220110 cites W1975534320 @default.
• W2589220110 cites W2001710332 @default.
• W2589220110 cites W2006236831 @default.
• W2589220110 cites W2016105256 @default.
• W2589220110 cites W2038591428 @default.
• W2589220110 cites W2046354477 @default.
• W2589220110 cites W2066571580 @default.
• W2589220110 cites W2077297620 @default.
• W2589220110 cites W2078361288 @default.
• W2589220110 cites W2084825289 @default.
• W2589220110 cites W2088328410 @default.
• W2589220110 cites W2092209491 @default.
• W2589220110 cites W2099443640 @default.
• W2589220110 cites W2104087345 @default.
• W2589220110 cites W2107455390 @default.
• W2589220110 cites W2111687223 @default.
• W2589220110 cites W2121940170 @default.
• W2589220110 cites W2125373439 @default.
• W2589220110 cites W2128733540 @default.
• W2589220110 cites W2135943092 @default.
• W2589220110 cites W2140821709 @default.
• W2589220110 cites W2141077451 @default.
• W2589220110 cites W2142409409 @default.
• W2589220110 cites W2150381417 @default.
• W2589220110 cites W2159959377 @default.
• W2589220110 cites W2162856159 @default.
• W2589220110 cites W2167318411 @default.
• W2589220110 cites W2185031176 @default.
• W2589220110 cites W2328778661 @default.
• W2589220110 cites W2329090280 @default.
• W2589220110 cites W2404696635 @default.
• W2589220110 doi "https://doi.org/10.3389/fneur.2017.00043" @default.
• W2589220110 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5317198" @default.
• W2589220110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28265257" @default.
• W2589220110 hasPublicationYear "2017" @default.
• W2589220110 type Work @default.
• W2589220110 sameAs 2589220110 @default.
• W2589220110 citedByCount "21" @default.
• W2589220110 countsByYear W25892201102017 @default.
• W2589220110 countsByYear W25892201102018 @default.
• W2589220110 countsByYear W25892201102019 @default.
• W2589220110 countsByYear W25892201102020 @default.
• W2589220110 countsByYear W25892201102021 @default.
• W2589220110 countsByYear W25892201102022 @default.
• W2589220110 countsByYear W25892201102023 @default.
• W2589220110 crossrefType "journal-article" @default.
• W2589220110 hasAuthorship W2589220110A5008739295 @default.
• W2589220110 hasAuthorship W2589220110A5030708251 @default.
• W2589220110 hasAuthorship W2589220110A5035428274 @default.
• W2589220110 hasAuthorship W2589220110A5045412256 @default.
• W2589220110 hasAuthorship W2589220110A5081570477 @default.
• W2589220110 hasBestOaLocation W25892201101 @default.
• W2589220110 hasConcept C113067387 @default.
• W2589220110 hasConcept C126322002 @default.
• W2589220110 hasConcept C139563560 @default.
• W2589220110 hasConcept C159654299 @default.
• W2589220110 hasConcept C187316574 @default.
• W2589220110 hasConcept C203014093 @default.
• W2589220110 hasConcept C2776090121 @default.
• W2589220110 hasConcept C2778105408 @default.
• W2589220110 hasConcept C2778453870 @default.
• W2589220110 hasConcept C2778607024 @default.
• W2589220110 hasConcept C2778690821 @default.
• W2589220110 hasConcept C2778957590 @default.
• W2589220110 hasConcept C2779359726 @default.
• W2589220110 hasConcept C2781438807 @default.
• W2589220110 hasConcept C553184892 @default.
• W2589220110 hasConcept C71924100 @default.
• W2589220110 hasConcept C8891405 @default.
• W2589220110 hasConceptScore W2589220110C113067387 @default.
• W2589220110 hasConceptScore W2589220110C126322002 @default.
• W2589220110 hasConceptScore W2589220110C139563560 @default.
• W2589220110 hasConceptScore W2589220110C159654299 @default.
• W2589220110 hasConceptScore W2589220110C187316574 @default.
• W2589220110 hasConceptScore W2589220110C203014093 @default.
• W2589220110 hasConceptScore W2589220110C2776090121 @default.
• W2589220110 hasConceptScore W2589220110C2778105408 @default.
• W2589220110 hasConceptScore W2589220110C2778453870 @default.
• W2589220110 hasConceptScore W2589220110C2778607024 @default.
• W2589220110 hasConceptScore W2589220110C2778690821 @default.

• next