Matches in SemOpenAlex for { <https://semopenalex.org/work/W2589291207> ?p ?o ?g. }
- W2589291207 endingPage "1163" @default.
- W2589291207 startingPage "1163" @default.
- W2589291207 abstract "To evaluate the role of biofilm formation on the resistance of Helicobacter pylori (H. pylori) to commonly prescribed antibiotics, the expression rates of resistance genes in biofilm-forming and planktonic cells were compared.A collection of 33 H. pylori isolates from children and adult patients with chronic infection were taken for the present study. The isolates were screened for biofilm formation ability, as well as for polymerase chain reaction (PCR) reaction with HP1165 and hp1165 efflux pump genes. Susceptibilities of the selected strains to antibiotic and differences between susceptibilities of planktonic and biofilm-forming cell populations were determined. Quantitative real-time PCR (qPCR) analysis was performed using 16S rRNA gene as a H. pylori-specific primer, and two efflux pumps-specific primers, hp1165 and hefA.The strains were resistant to amoxicillin, metronidazole, and erythromycin, except for one strain, but they were all susceptible to tetracycline. Minimum bactericidal concentrations of antibiotics in the biofilm-forming cells were significantly higher than those of planktonic cells. qPCR demonstrated that the expression of efflux pump genes was significantly higher in the biofilm-forming cells as compared to the planktonic ones.The present work demonstrated an association between H. pylori biofilm formation and decreased susceptibility to all the antibiotics tested. This decreased susceptibility to antibiotics was associated with enhanced functional activity of two efflux pumps: hp1165 and hefA." @default.
- W2589291207 created "2017-03-03" @default.
- W2589291207 creator A5003862334 @default.
- W2589291207 creator A5011048156 @default.
- W2589291207 creator A5063928663 @default.
- W2589291207 date "2017-01-01" @default.
- W2589291207 modified "2023-10-10" @default.
- W2589291207 title "Effect of biofilm formation by clinical isolates of<i>Helicobacter pylori</i>on the efflux-mediated resistance to commonly used antibiotics" @default.
- W2589291207 cites W1608319452 @default.
- W2589291207 cites W1862098312 @default.
- W2589291207 cites W1970374612 @default.
- W2589291207 cites W1977574307 @default.
- W2589291207 cites W1981915387 @default.
- W2589291207 cites W2011775811 @default.
- W2589291207 cites W2025986883 @default.
- W2589291207 cites W2028391708 @default.
- W2589291207 cites W2032673894 @default.
- W2589291207 cites W2035900467 @default.
- W2589291207 cites W2038668661 @default.
- W2589291207 cites W2063199331 @default.
- W2589291207 cites W2074686965 @default.
- W2589291207 cites W2085942087 @default.
- W2589291207 cites W2096034349 @default.
- W2589291207 cites W2104312738 @default.
- W2589291207 cites W2107956351 @default.
- W2589291207 cites W2111832211 @default.
- W2589291207 cites W2112063053 @default.
- W2589291207 cites W2114144364 @default.
- W2589291207 cites W2114943342 @default.
- W2589291207 cites W2120419039 @default.
- W2589291207 cites W2122836009 @default.
- W2589291207 cites W2124225477 @default.
- W2589291207 cites W2135484119 @default.
- W2589291207 cites W2136734723 @default.
- W2589291207 cites W2145589079 @default.
- W2589291207 cites W2150071589 @default.
- W2589291207 cites W2151144296 @default.
- W2589291207 cites W2153354382 @default.
- W2589291207 cites W2158458733 @default.
- W2589291207 cites W2169896838 @default.
- W2589291207 cites W2293346959 @default.
- W2589291207 cites W2414957455 @default.
- W2589291207 doi "https://doi.org/10.3748/wjg.v23.i7.1163" @default.
- W2589291207 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5323441" @default.
- W2589291207 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28275296" @default.
- W2589291207 hasPublicationYear "2017" @default.
- W2589291207 type Work @default.
- W2589291207 sameAs 2589291207 @default.
- W2589291207 citedByCount "33" @default.
- W2589291207 countsByYear W25892912072017 @default.
- W2589291207 countsByYear W25892912072018 @default.
- W2589291207 countsByYear W25892912072019 @default.
- W2589291207 countsByYear W25892912072020 @default.
- W2589291207 countsByYear W25892912072021 @default.
- W2589291207 countsByYear W25892912072022 @default.
- W2589291207 countsByYear W25892912072023 @default.
- W2589291207 crossrefType "journal-article" @default.
- W2589291207 hasAuthorship W2589291207A5003862334 @default.
- W2589291207 hasAuthorship W2589291207A5011048156 @default.
- W2589291207 hasAuthorship W2589291207A5063928663 @default.
- W2589291207 hasBestOaLocation W25892912071 @default.
- W2589291207 hasConcept C104317684 @default.
- W2589291207 hasConcept C200082930 @default.
- W2589291207 hasConcept C2776409635 @default.
- W2589291207 hasConcept C2779708577 @default.
- W2589291207 hasConcept C2780206985 @default.
- W2589291207 hasConcept C2780923616 @default.
- W2589291207 hasConcept C49105822 @default.
- W2589291207 hasConcept C501593827 @default.
- W2589291207 hasConcept C523546767 @default.
- W2589291207 hasConcept C54355233 @default.
- W2589291207 hasConcept C55493867 @default.
- W2589291207 hasConcept C58123911 @default.
- W2589291207 hasConcept C86803240 @default.
- W2589291207 hasConcept C89423630 @default.
- W2589291207 hasConcept C94665300 @default.
- W2589291207 hasConceptScore W2589291207C104317684 @default.
- W2589291207 hasConceptScore W2589291207C200082930 @default.
- W2589291207 hasConceptScore W2589291207C2776409635 @default.
- W2589291207 hasConceptScore W2589291207C2779708577 @default.
- W2589291207 hasConceptScore W2589291207C2780206985 @default.
- W2589291207 hasConceptScore W2589291207C2780923616 @default.
- W2589291207 hasConceptScore W2589291207C49105822 @default.
- W2589291207 hasConceptScore W2589291207C501593827 @default.
- W2589291207 hasConceptScore W2589291207C523546767 @default.
- W2589291207 hasConceptScore W2589291207C54355233 @default.
- W2589291207 hasConceptScore W2589291207C55493867 @default.
- W2589291207 hasConceptScore W2589291207C58123911 @default.
- W2589291207 hasConceptScore W2589291207C86803240 @default.
- W2589291207 hasConceptScore W2589291207C89423630 @default.
- W2589291207 hasConceptScore W2589291207C94665300 @default.
- W2589291207 hasIssue "7" @default.
- W2589291207 hasLocation W25892912071 @default.
- W2589291207 hasLocation W25892912072 @default.
- W2589291207 hasLocation W25892912073 @default.
- W2589291207 hasLocation W25892912074 @default.
- W2589291207 hasOpenAccess W2589291207 @default.
- W2589291207 hasPrimaryLocation W25892912071 @default.