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• W2589299457 abstract "// Qing-Jian Wu 1, 2, 3, * , Shu-Yin Sun 1, * , Cheng-Jun Yan 1, * , Zi-Cui Cheng 4 , Ming-Feng Yang 3 , Zi-Fei Li 1 , Hou-Wen Cheng 3 , Ti-Kun Fang 1 1 Department of Emergency, Jining No. 1 People’s Hospital, Jining, Shandong, 272011, China 2 Department of Neurology, Shandong University School of Medicine, Jinan, Shandong, 250012, China 3 Key Lab of Cerebral Microcirculation in Universities of Shandong, Taishan Medical University, Taian, Shandong, 271000, China 4 Department of Encephalopathy Rehabiliation Center, Taian Traditional Chinese Medical Hospital, Taian, Shandong, 271000, China * These authors have contributed equally to this work Correspondence to: Ti-Kun Fang, email: 181773844@qq.com Keywords: Alzheimer’s disease, genome-wide association studies, EXOC3L2, rs597668 Received: November 17, 2016      Accepted: January 11, 2017      Published: February 16, 2017 ABSTRACT Recent genome-wide association studies have established the association between EXOC3L2 rs597668 variant and Alzheimer’s disease (AD) in European population. However, recent studies reported inconsistent results in Asian population. Here, we performed a systematic review and meta-analysis to evaluate the impact of rs597668 on AD risk in Asian population using a total of 8686 samples including 2855 cases and 5831 controls. Meanwhile, we selected 17,008 AD cases and 37,154 controls in European population to evaluate the potential heterogeneity between East Asian and European populations. In East Asian population, we identified no potential heterogeneity with P =0.31 and I 2 = 15.8%. By meta-analysis, we identified positive association between rs597668 and AD risk with P =0.023, OR=0.93, 95% CI 0.87-0.99. We further found significant heterogeneity in pooled Asian and European populations with P <0.0001 and I 2 = 87.7%. The meta-analysis indicated negative association with P =0.66, OR=0.97, 95% CI 0.85-1.11. In summary, all these findings indicate that rs597668 C allele is a risk factor for AD in European population with OR=1.18 and P =2.49E-13. However the rs597668 C allele played a protective role in AD with OR=0.93 and P =0.023 in East Asian population." @default.
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• W2589299457 date "2017-02-16" @default.
• W2589299457 modified "2023-10-17" @default.
• W2589299457 title "EXOC3L2 rs597668 variant contributes to Alzheimer’s disease susceptibility in Asian population" @default.
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• W2589299457 doi "https://doi.org/10.18632/oncotarget.15380" @default.
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