FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2589359287> ?p ?o ?g. }

• W2589359287 endingPage "22115" @default.
• W2589359287 startingPage "22115" @default.
• W2589359287 abstract "22115 Background: Several tumors have been linked to chronic exposure to polycyclic aromatic hydrocarbons (PAHs) found in food and tobacco smoke. PAHs are bioactivated by the CYP1A1 enzymes. An A→G substitution at nucleotide 4889 and a T→C substitution at nucleotide 6235 of the CYP1A1 gene lead to the production of more active enzymes. Cancer and environmental-related diseases due to tobacco exposure have been described as serious health problems in the south-eastern Brazil. Therefore, the aim of this study was to evaluate the influence of the CYP1A1 A4889G and T6235C genotypes for cancer risk in individuals of this region. Methods: DNA from 525 cancer patients, including 133 acute myeloid leukemia (AML), 250 colorectal cancer (CC) and 142 head and neck cancer (HNC), and 529 age and race-matched controls were analyzed by polymerase chain reaction and enzymatic digestion. Results: Similar frequencies of the CYP1A1 4889AG+GG genotype were seen in AML (43.6% versus 30.8%), in CC (22.0% versus 27.2%) and in HNC (33.8% versus 28.2%) patients and controls. Individuals with the distinct genotypes were under similar risks for diseases. Similar frequencies of CYP1A1 6235TC+CC genotype were seen in CC (29.0% versus 36.1%) and HNC (36.6% versus 33.8%) patients and controls. Individuals with the distinct genotypes were under similar risk for CC and HNC. However, the frequency of the CYP1A1 6235TC+CC genotype was significantly higher in AML patients than in controls (51.1% vs 28.6%; P < 0.001). Carriers of the CYP1A1 T6235C variant allele (C) were under a 2.8-fold increased risk of AML (95% CI: 1.67–4.84). Moreover, the frequency of the CYP1A1 6235TC+CC genotype was lower in patients with tumor of larinx than in those with other HN tumors (8 of 37 versus 44 of 105; P = 0.03) and higher in patients with low ingestion of vegetables than in others (46 of 133 versus 4 of 29; P = 0.024). Conclusion: These results suggest that the inherited CYP1A1 T6235C variant genotypes, involved in the pathways of carcinogens metabolism, alter the risk for AML and CC in accord to the pattern of vegetables ingestion, and the location of HNC in individuals of south-eastern Brazil. Financial support: FAPESP and CNPq No significant financial relationships to disclose." @default.
• W2589359287 created "2017-03-03" @default.
• W2589359287 creator A5001318967 @default.
• W2589359287 creator A5010602768 @default.
• W2589359287 creator A5025079699 @default.
• W2589359287 creator A5025795429 @default.
• W2589359287 creator A5033817648 @default.
• W2589359287 creator A5038987444 @default.
• W2589359287 creator A5045900041 @default.
• W2589359287 creator A5054428341 @default.
• W2589359287 creator A5079076378 @default.
• W2589359287 creator A5079461444 @default.
• W2589359287 date "2008-05-20" @default.
• W2589359287 modified "2023-09-26" @default.
• W2589359287 title "The role of the CYP1A1 gene defects in cancer risk in south-eastern Brazil" @default.
• W2589359287 doi "https://doi.org/10.1200/jco.2008.26.15_suppl.22115" @default.
• W2589359287 hasPublicationYear "2008" @default.
• W2589359287 type Work @default.
• W2589359287 sameAs 2589359287 @default.
• W2589359287 citedByCount "1" @default.
• W2589359287 crossrefType "journal-article" @default.
• W2589359287 hasAuthorship W2589359287A5001318967 @default.
• W2589359287 hasAuthorship W2589359287A5010602768 @default.
• W2589359287 hasAuthorship W2589359287A5025079699 @default.
• W2589359287 hasAuthorship W2589359287A5025795429 @default.
• W2589359287 hasAuthorship W2589359287A5033817648 @default.
• W2589359287 hasAuthorship W2589359287A5038987444 @default.
• W2589359287 hasAuthorship W2589359287A5045900041 @default.
• W2589359287 hasAuthorship W2589359287A5054428341 @default.
• W2589359287 hasAuthorship W2589359287A5079076378 @default.
• W2589359287 hasAuthorship W2589359287A5079461444 @default.
• W2589359287 hasConcept C104317684 @default.
• W2589359287 hasConcept C121608353 @default.
• W2589359287 hasConcept C126322002 @default.
• W2589359287 hasConcept C135763542 @default.
• W2589359287 hasConcept C2778461978 @default.
• W2589359287 hasConcept C2778729363 @default.
• W2589359287 hasConcept C49105822 @default.
• W2589359287 hasConcept C526805850 @default.
• W2589359287 hasConcept C54355233 @default.
• W2589359287 hasConcept C71924100 @default.
• W2589359287 hasConcept C86803240 @default.
• W2589359287 hasConcept C90924648 @default.
• W2589359287 hasConceptScore W2589359287C104317684 @default.
• W2589359287 hasConceptScore W2589359287C121608353 @default.
• W2589359287 hasConceptScore W2589359287C126322002 @default.
• W2589359287 hasConceptScore W2589359287C135763542 @default.
• W2589359287 hasConceptScore W2589359287C2778461978 @default.
• W2589359287 hasConceptScore W2589359287C2778729363 @default.
• W2589359287 hasConceptScore W2589359287C49105822 @default.
• W2589359287 hasConceptScore W2589359287C526805850 @default.
• W2589359287 hasConceptScore W2589359287C54355233 @default.
• W2589359287 hasConceptScore W2589359287C71924100 @default.
• W2589359287 hasConceptScore W2589359287C86803240 @default.
• W2589359287 hasConceptScore W2589359287C90924648 @default.
• W2589359287 hasIssue "15_suppl" @default.
• W2589359287 hasLocation W25893592871 @default.
• W2589359287 hasOpenAccess W2589359287 @default.
• W2589359287 hasPrimaryLocation W25893592871 @default.
• W2589359287 hasRelatedWork W2075214100 @default.
• W2589359287 hasRelatedWork W2135103772 @default.
• W2589359287 hasRelatedWork W2188112266 @default.
• W2589359287 hasRelatedWork W2381416288 @default.
• W2589359287 hasRelatedWork W2386662296 @default.
• W2589359287 hasRelatedWork W2387170741 @default.
• W2589359287 hasRelatedWork W2388808113 @default.
• W2589359287 hasRelatedWork W2392730113 @default.
• W2589359287 hasRelatedWork W3004259476 @default.
• W2589359287 hasRelatedWork W4317776109 @default.
• W2589359287 hasVolume "26" @default.
• W2589359287 isParatext "false" @default.
• W2589359287 isRetracted "false" @default.
• W2589359287 magId "2589359287" @default.
• W2589359287 workType "article" @default.