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• W2589366298 abstract "Diabetes mellitus is a disease that poses a burden to the health care system due to its prevalence and chronic nature. Understanding β cell pathophysiology may lead to future therapeutic options for diabetes mellitus type 1 and 2. MicroRNAs (MiR) fine-tune β cell biochemical cascades through specific protein targets. This review argues that miRs may play a critical role in human islet β cell biology and are potential candidates for a new pharmacological strategy. We have reviewed and presented how miRs fine tune four biochemical cascades in islet β cells: glucose stimulated insulin secretion, β cell replication, apoptosis, and development. Only studies that examine human pancreatic islets either in vitro or in vivo are included. The unveiling role of miR pathways in regulating human islet β cell biology could open the door for diagnostic and therapeutic methods for diabetes mellitus prevention and therapy." @default.
• W2589366298 created "2017-03-03" @default.
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• W2589366298 date "2015-01-01" @default.
• W2589366298 modified "2023-10-05" @default.
• W2589366298 title "The Biochemical Cascades of the Human Pancreatic β-Cells: The Role of MicroRNAs" @default.
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• W2589366298 doi "https://doi.org/10.4172/1948-593x.1000e133" @default.
• W2589366298 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5426857" @default.
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• W2589366298 hasPublicationYear "2015" @default.
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