Matches in SemOpenAlex for { <https://semopenalex.org/work/W2589408026> ?p ?o ?g. }
- W2589408026 abstract "The rostral migratory stream (RMS) is viewed as a glia-enriched conduit of forward-migrating neuroblasts in which chemorepulsive signals control the pace of forward migration. Here we demonstrate the existence of a scaffold of neurons that receive synaptic inputs within the rat, mouse, and human fetal RMS equivalents. These neurons express secretagogin, a Ca2+-sensor protein, to execute an annexin V-dependent externalization of matrix metalloprotease-2 (MMP-2) for reconfiguring the extracellular matrix locally. Mouse genetics combined with pharmacological probing in vivo and in vitro demonstrate that MMP-2 externalization occurs on demand and that its loss slows neuroblast migration. Loss of function is particularly remarkable upon injury to the olfactory bulb. Cumulatively, we identify a signaling cascade that provokes structural remodeling of the RMS through recruitment of MMP-2 by a previously unrecognized neuronal constituent. Given the life-long presence of secretagogin-containing neurons in human, this mechanism might be exploited for therapeutic benefit in rescue strategies." @default.
- W2589408026 created "2017-03-03" @default.
- W2589408026 creator A5007444625 @default.
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- W2589408026 creator A5082644975 @default.
- W2589408026 date "2017-02-21" @default.
- W2589408026 modified "2023-10-17" @default.
- W2589408026 title "Secretagogin-dependent matrix metalloprotease-2 release from neurons regulates neuroblast migration" @default.
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