FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2589431353> ?p ?o ?g. }

• W2589431353 endingPage "6" @default.
• W2589431353 startingPage "1" @default.
• W2589431353 abstract "Severe acute pancreatitis (SAP) starts as a local inflammation of pancreatic tissue that induces the development of multiple extrapancreatic organs dysfunction; however, the underlying mechanisms are still not clear. Ischemia-reperfusion, circulating inflammatory cytokines, and possible bile cytokines significantly contribute to gut mucosal injury and intestinal bacterial translocation (BT) during SAP. Circulating HMGB1 level is significantly increased in SAP patients and HMGB1 is an important factor that mediates (at least partly) gut BT during SAP. Gut BT plays a critical role in triggering/inducing systemic inflammation/sepsis in critical illness, and profound systemic inflammatory response syndrome (SIRS) can lead to multiple organ dysfunction syndrome (MODS) during SAP, and systemic inflammation with multiorgan dysfunction is the cause of death in experimental SAP. Therefore, HMGB1 is an important factor that links gut BT and systemic inflammation. Furthermore, HMGB1 significantly contributes to multiple organ injuries. The SAP patients also have significantly increased circulating histones and cell-free DNAs levels, which can reflect the disease severity and contribute to multiple organ injuries in SAP. Hepatic Kupffer cells (KCs) are the predominant source of circulating inflammatory cytokines in SAP, and new evidence indicates that hepatocyte is another important source of circulating HMGB1 in SAP; therefore, treating the liver injury is important in SAP." @default.
• W2589431353 created "2017-03-03" @default.
• W2589431353 creator A5016832104 @default.
• W2589431353 creator A5030000245 @default.
• W2589431353 creator A5085809097 @default.
• W2589431353 date "2017-01-01" @default.
• W2589431353 modified "2023-10-01" @default.
• W2589431353 title "HMGB1 and Histones Play a Significant Role in Inducing Systemic Inflammation and Multiple Organ Dysfunctions in Severe Acute Pancreatitis" @default.
• W2589431353 cites W1464666752 @default.
• W2589431353 cites W1468684773 @default.
• W2589431353 cites W1490094768 @default.
• W2589431353 cites W169488080 @default.
• W2589431353 cites W1718393048 @default.
• W2589431353 cites W1822135553 @default.
• W2589431353 cites W1822736618 @default.
• W2589431353 cites W1967201899 @default.
• W2589431353 cites W1972540842 @default.
• W2589431353 cites W1973082103 @default.
• W2589431353 cites W1973299402 @default.
• W2589431353 cites W1978508787 @default.
• W2589431353 cites W1981824763 @default.
• W2589431353 cites W1983379130 @default.
• W2589431353 cites W1995067734 @default.
• W2589431353 cites W2005714581 @default.
• W2589431353 cites W2011598001 @default.
• W2589431353 cites W2017608624 @default.
• W2589431353 cites W2017716899 @default.
• W2589431353 cites W2019139855 @default.
• W2589431353 cites W2023175983 @default.
• W2589431353 cites W2023532695 @default.
• W2589431353 cites W2026754993 @default.
• W2589431353 cites W2032025454 @default.
• W2589431353 cites W2036547525 @default.
• W2589431353 cites W2037867667 @default.
• W2589431353 cites W2038696080 @default.
• W2589431353 cites W2039149071 @default.
• W2589431353 cites W2041385257 @default.
• W2589431353 cites W2042403212 @default.
• W2589431353 cites W2044384913 @default.
• W2589431353 cites W2047478576 @default.
• W2589431353 cites W2048379363 @default.
• W2589431353 cites W2057939308 @default.
• W2589431353 cites W2068436393 @default.
• W2589431353 cites W2070531069 @default.
• W2589431353 cites W2070678323 @default.
• W2589431353 cites W2070790650 @default.
• W2589431353 cites W2071383186 @default.
• W2589431353 cites W2081272135 @default.
• W2589431353 cites W2081770560 @default.
• W2589431353 cites W2084388692 @default.
• W2589431353 cites W2090300161 @default.
• W2589431353 cites W2094888593 @default.
• W2589431353 cites W2100277562 @default.
• W2589431353 cites W2102641420 @default.
• W2589431353 cites W2102831728 @default.
• W2589431353 cites W2112211760 @default.
• W2589431353 cites W2122196470 @default.
• W2589431353 cites W2123805133 @default.
• W2589431353 cites W2125519804 @default.
• W2589431353 cites W2130591775 @default.
• W2589431353 cites W2133702169 @default.
• W2589431353 cites W2134046896 @default.
• W2589431353 cites W2135131688 @default.
• W2589431353 cites W2138922597 @default.
• W2589431353 cites W2140609738 @default.
• W2589431353 cites W2142365299 @default.
• W2589431353 cites W2154948627 @default.
• W2589431353 cites W2168020443 @default.
• W2589431353 cites W2168394276 @default.
• W2589431353 cites W2171249563 @default.
• W2589431353 cites W2179661158 @default.
• W2589431353 cites W2276171136 @default.
• W2589431353 cites W2340955726 @default.
• W2589431353 cites W2383509709 @default.
• W2589431353 cites W2397416972 @default.
• W2589431353 cites W2460079023 @default.
• W2589431353 cites W291945684 @default.
• W2589431353 cites W4245265561 @default.
• W2589431353 doi "https://doi.org/10.1155/2017/1817564" @default.
• W2589431353 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5339498" @default.
• W2589431353 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28316860" @default.
• W2589431353 hasPublicationYear "2017" @default.
• W2589431353 type Work @default.
• W2589431353 sameAs 2589431353 @default.
• W2589431353 citedByCount "39" @default.
• W2589431353 countsByYear W25894313532017 @default.
• W2589431353 countsByYear W25894313532018 @default.
• W2589431353 countsByYear W25894313532019 @default.
• W2589431353 countsByYear W25894313532020 @default.
• W2589431353 countsByYear W25894313532021 @default.
• W2589431353 countsByYear W25894313532022 @default.
• W2589431353 countsByYear W25894313532023 @default.
• W2589431353 crossrefType "journal-article" @default.
• W2589431353 hasAuthorship W2589431353A5016832104 @default.
• W2589431353 hasAuthorship W2589431353A5030000245 @default.
• W2589431353 hasAuthorship W2589431353A5085809097 @default.
• W2589431353 hasBestOaLocation W25894313531 @default.
• W2589431353 hasConcept C126322002 @default.

• next