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- W2589435172 abstract "：Objective To compare theeffects of intermittent high blood glucose and consistent hilgh blood glucose onpancreatic islet β-cell function and β-cell apoptosis in GKrats.Methods Twenty-two male GK rats were randomly divided into 2 groups consisting ofconsistent hish blood glucose group(HG)and intermittent high blood glucosegroup(FG).Eleven male Wistar rats were used as normal glucose controls(NG).The fluctuatinghigh blood glucose animal model was induced by intraperitoneal injection of insulin andglucose at different time for six weeks.Intraperitoneal injection glucose tolerance testand insulin release test were performed.The area under curve of glucose(AUCg).the areaunder carve of insulin(AUCi)/AUCg and the ratio of insulin increment to blood glucoseincrement 15 min after glucose load(Δ115'/ΔG15')werecalculated routinely.Then the pancreatic slides were stained with insulin antibody.Theapoptotic β cells in islets were detectedand quantified by the TUNEL technique.Results(1)The fasting plasma glucose and15,30,60,and 120 min plasma glucose levels after glucose loading in FG group weresignificantly higher than those in control group(all P<0.01),and AUCg was also markedlyincreased[(1 012.14±82.62 vs 813.60±56.70)ng·ml~(-1)·h~(-1)·10~4,P<0.01].Insulinlevels of FG group at 15,30,60,and 120 rain after glucose loading were significantly lowerthan those in HG group[(0.554± 0.18 vs 0.95±0.28.0.43±0.17 vs 0.85±0.21,0.47±0.11 vs0.76±0.16,0.58±0.13 vs 1.08±0.26)ng/ml,P<0.05],along with decreased AUCi/AUCg andΔ115'/ΔG15'[(9.56±2.53 vs 21.36±4.16)×10~(-7);(3.95±3.45 vs 27.02±8.62)×10~(-7),bothP<0.05].(2)Image analysis of pancreatic islet immunocytoehemistry showed that theinsulin staining positive area,area ratio and total density of insulin positive cells perislet were significantly lower in FG group than those in HG group(P<0.05).(3)Thepercentage of β-cell apoptosis in the FG group was statistically higher than thatin the HG group[(24.17±7.25 vs 16.55±5.11)%,P<0.01].Conclusion Compared with theconsistent high blood glucose,intermittent high glucose could lead to further impairmentof β-cell function and increased β-cell apoptosis may partiallycontribute to this process." @default.
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- W2589435172 date "2010-01-25" @default.
- W2589435172 modified "2023-09-22" @default.
- W2589435172 title "Effects of intermittent high glucose on islet β-cell function and apoptosis in GK rats" @default.
- W2589435172 doi "https://doi.org/10.3760/cma.j.issn.1000-6699.2010.01.014" @default.
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