Matches in SemOpenAlex for { <https://semopenalex.org/work/W2589485488> ?p ?o ?g. }
- W2589485488 endingPage "1752" @default.
- W2589485488 startingPage "1743" @default.
- W2589485488 abstract "Diacylglycerol kinases (DGKs) are important regulators of cell signaling and have been implicated in human malignancies. Whether epigenetic alterations are involved in the dysregulation of DGKs in cancer is unknown, however. We therefore analyzed methylation of the promoter CpG islands of DGK genes in colorectal cancer (CRC) cell lines. We found that DGKG, which encodes DGKγ, was hypermethylated in all CRC cell lines tested (n = 9), but was not methylated in normal colonic tissue. Correspondingly, DGKG expression was suppressed in CRC cell lines but not in normal colonic tissue, and was restored in CRC cells by treatment with the DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine (5-aza-dC). DGKG methylation was frequently observed in primary CRCs (73/141, 51.8%) and was positively associated with KRAS and BRAF mutations and with the CpG island methylator phenotype (CIMP). DGKG methylation was also frequently detected in colorectal adenomas (89 of 177, 50.3%), which suggests it is an early event during colorectal tumorigenesis. Ectopic expression of wild-type DGKγ did not suppress CRC cell proliferation, but did suppress cell migration and invasion. Notably, both constitutively active and kinase-dead DGKγ mutants exerted inhibitory effects on CRC cell proliferation, migration and invasion, and the wild-type and mutant forms of DGKγ all suppressed Rac1 activity in CRC cells. These data suggest DGKG may play a tumor suppressor role in CRC." @default.
- W2589485488 created "2017-03-03" @default.
- W2589485488 creator A5002391399 @default.
- W2589485488 creator A5015427845 @default.
- W2589485488 creator A5020903260 @default.
- W2589485488 creator A5027174579 @default.
- W2589485488 creator A5033361967 @default.
- W2589485488 creator A5044409221 @default.
- W2589485488 creator A5044510659 @default.
- W2589485488 creator A5049246136 @default.
- W2589485488 creator A5050959893 @default.
- W2589485488 creator A5059282349 @default.
- W2589485488 creator A5064856279 @default.
- W2589485488 creator A5074222770 @default.
- W2589485488 creator A5076679350 @default.
- W2589485488 creator A5080167967 @default.
- W2589485488 creator A5086634951 @default.
- W2589485488 creator A5088527994 @default.
- W2589485488 date "2017-03-06" @default.
- W2589485488 modified "2023-09-30" @default.
- W2589485488 title "Epigenetic silencing of diacylglycerol kinase gamma in colorectal cancer" @default.
- W2589485488 cites W1534992900 @default.
- W2589485488 cites W1923234847 @default.
- W2589485488 cites W1964021043 @default.
- W2589485488 cites W1967385667 @default.
- W2589485488 cites W1972895585 @default.
- W2589485488 cites W1977068073 @default.
- W2589485488 cites W1993557483 @default.
- W2589485488 cites W2010241172 @default.
- W2589485488 cites W2013706577 @default.
- W2589485488 cites W2049831696 @default.
- W2589485488 cites W2059672809 @default.
- W2589485488 cites W2060584742 @default.
- W2589485488 cites W2077166985 @default.
- W2589485488 cites W2082671589 @default.
- W2589485488 cites W2087700852 @default.
- W2589485488 cites W2093188241 @default.
- W2589485488 cites W2111264907 @default.
- W2589485488 cites W2115540784 @default.
- W2589485488 cites W2134212296 @default.
- W2589485488 cites W2135105302 @default.
- W2589485488 cites W2137609081 @default.
- W2589485488 cites W2148542386 @default.
- W2589485488 cites W2154294588 @default.
- W2589485488 cites W2155088820 @default.
- W2589485488 cites W2166817392 @default.
- W2589485488 cites W2167945766 @default.
- W2589485488 cites W2168589482 @default.
- W2589485488 cites W2332307736 @default.
- W2589485488 cites W2412871407 @default.
- W2589485488 doi "https://doi.org/10.1002/mc.22631" @default.
- W2589485488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28218473" @default.
- W2589485488 hasPublicationYear "2017" @default.
- W2589485488 type Work @default.
- W2589485488 sameAs 2589485488 @default.
- W2589485488 citedByCount "24" @default.
- W2589485488 countsByYear W25894854882018 @default.
- W2589485488 countsByYear W25894854882019 @default.
- W2589485488 countsByYear W25894854882020 @default.
- W2589485488 countsByYear W25894854882021 @default.
- W2589485488 countsByYear W25894854882022 @default.
- W2589485488 countsByYear W25894854882023 @default.
- W2589485488 crossrefType "journal-article" @default.
- W2589485488 hasAuthorship W2589485488A5002391399 @default.
- W2589485488 hasAuthorship W2589485488A5015427845 @default.
- W2589485488 hasAuthorship W2589485488A5020903260 @default.
- W2589485488 hasAuthorship W2589485488A5027174579 @default.
- W2589485488 hasAuthorship W2589485488A5033361967 @default.
- W2589485488 hasAuthorship W2589485488A5044409221 @default.
- W2589485488 hasAuthorship W2589485488A5044510659 @default.
- W2589485488 hasAuthorship W2589485488A5049246136 @default.
- W2589485488 hasAuthorship W2589485488A5050959893 @default.
- W2589485488 hasAuthorship W2589485488A5059282349 @default.
- W2589485488 hasAuthorship W2589485488A5064856279 @default.
- W2589485488 hasAuthorship W2589485488A5074222770 @default.
- W2589485488 hasAuthorship W2589485488A5076679350 @default.
- W2589485488 hasAuthorship W2589485488A5080167967 @default.
- W2589485488 hasAuthorship W2589485488A5086634951 @default.
- W2589485488 hasAuthorship W2589485488A5088527994 @default.
- W2589485488 hasConcept C104317684 @default.
- W2589485488 hasConcept C111669997 @default.
- W2589485488 hasConcept C119056186 @default.
- W2589485488 hasConcept C121608353 @default.
- W2589485488 hasConcept C150194340 @default.
- W2589485488 hasConcept C184235292 @default.
- W2589485488 hasConcept C190727270 @default.
- W2589485488 hasConcept C195794163 @default.
- W2589485488 hasConcept C2779277951 @default.
- W2589485488 hasConcept C2781187634 @default.
- W2589485488 hasConcept C33288867 @default.
- W2589485488 hasConcept C36020004 @default.
- W2589485488 hasConcept C41091548 @default.
- W2589485488 hasConcept C502942594 @default.
- W2589485488 hasConcept C526805850 @default.
- W2589485488 hasConcept C54355233 @default.
- W2589485488 hasConcept C555283112 @default.
- W2589485488 hasConcept C62112901 @default.
- W2589485488 hasConcept C81885089 @default.