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- W2589490384 abstract "B. burgdorferi has a wide variety ofstrategies to hide from the host immune system. Complement regulatorybinding proteins have been described for almost all complement resistant B.burgdorferi sl, except for the complement resistant B. bavariensis, one of thespecies that is known to frequently cause Lyme neuroborreliosis.In chapter 2 it is attempted to identify CRASP-1 proteins in B. bavariensis,formerly known as B. garinii OspA serotype 4. Potential CRASP-1 proteins will becloned and studied for their ability to interact with host derived fluid phaseregulators of complement.The specific role of complement resistance in early effective infection anddissemination of B. burgdorferi sl has not been well investigated. Cancomplement resistance lead to a better and more effective infection anddissemination? In chapter 3 an in vivo experiment in which the infectivity anddissemination patterns of complement sensitive and complement resistant B.burgdorferi sl in a C3 deficient mouse model is described.After effective transmission from the tick to the host the next challenge in B.burgdorferi infection is rapid and accurate detection of the pathogen.Diagnostics of Lyme disease is often compromised due to specific pathogenproperties combined with technical shortcomings of bacterial serology.Two indirect detection methods which can aid in diagnosing patients sufferingfrom Lyme neuroborreliosis were studied. In chapter 4 the performance of theC6-peptide ELISA for detecting antibodies in CSF in Lyme neuroborreliosispatients is studied. While in chapter 5 levels of CXCL13 in several patientpopulations as a potential biomarker for the diagnosis of Lyme neuroborreliosisis studied.For both indirect markers of presence of B. burgdorferi the specificity inclinically resembling and neuroinfectious diseases is of key importance. Severalother infectious and inflammatory diseases that have a clinical presentationthat can resemble Lyme disease are included in the analysis.Diagnosing Lyme disease can be difficult in some populations, first becauseLyme disease is a relatively rare infection, resembling a large spectrum of otherautoimmune and inflammatory diseases. Clinicians could often consider testingfor Lyme disease. It is also important to do this in specific preselectedpopulations, because the positive predictive value of a test, but specificallyindirect tests such as serology, in a random population, is low.In chapter 6 all patients that present with complaints of arthritis at the earlyarthritis clinic are tested for Lyme arthritis. The prevalence of B. burgdorferiseropositivity in this population is studied. Another aim is to identify clinicalfactors which should urge the doctor to test, or explicitely not test, for Lymedisease in a patient presenting with arthritis in Europe.In chapter 7 a case of an HIV positive patient presenting with a meningoencephalitiscaused by B. burgdorferi is described. The literature on HIV andLyme neuroborreliosis co-infections is also reviewed." @default.
- W2589490384 created "2017-03-03" @default.
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- W2589490384 date "2013-05-29" @default.
- W2589490384 modified "2023-09-23" @default.
- W2589490384 title "Host-pathogen interactions in Lyme disease and their application in diagnostics" @default.
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