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- W2589493923 endingPage "258" @default.
- W2589493923 startingPage "233" @default.
- W2589493923 abstract "The homeostasis of eukaryotic cells relies on efficient mitochondrial function. The control of mitochondrial quality is framed by the combination of distinct but interdependent mechanisms spanning biogenesis, regulation of dynamic network, and finely tuned degradation either through ubiquitin-proteasome system or autophagy (mitophagy). There is continuous evolution on the pathways orchestrating the mitochondrial response to stress signals and the organelle adaptation to quality control during acute and subtle dysfunctions. Notably, it remains indeed ill-defined whether active mitophagy leads to cell survival or death by defective mitochondrial degradation. Above all, uncharted is whether and how pharmacologically tackle these mechanisms may lead to conceive novel therapeutic strategies for treating conditions associated with the defective mitochondria. Here, we attempt to provide a chronological and comprehensive overview of the determining discoveries, which have led to the current knowledge of mitophagy." @default.
- W2589493923 created "2017-03-03" @default.
- W2589493923 creator A5016133215 @default.
- W2589493923 creator A5021111706 @default.
- W2589493923 creator A5032006810 @default.
- W2589493923 creator A5075732396 @default.
- W2589493923 date "2017-01-01" @default.
- W2589493923 modified "2023-10-17" @default.
- W2589493923 title "Molecular Biology Digest of Cell Mitophagy" @default.
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