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• W2589505737 abstract "3653 Background: Surveillance in patients (pts) with CRC remains a controversial issue except detection of antigen carcinoembryonic (CEA) and colonoscopy. Better surgery and locoregional techniques along with more active regimens of chemotherapy (ChT) have improved the results of salvage treatments. Therefore imaging techniques may be useful in the detection of early relapses. We present our experience. Methods: From 1993 to 1999 all pts with stage II and III CRC treated with adjuvant treatment have been analysed. The follow-up schedule was clinical visit and CEA every 3 moths (m) 2 years (y), every 4 m the third y, every 6 m the fourth and fifth y and annually afterwards; chest X-ray annually and abdominal US every 6 m for 2 y and annually to complete 5 y. Abdominal CT scan was performed in rectal cancer (RC) annually for 2 y. Colonoscopy was done at first y and every 2 y. We calculate overall survival (OS) of the pts with relapses from date of relapse to death. Kaplan-Meier survival curves were compared with long rank test. Results: We analysed 611 pts, 311 colon (CC) (II 117, III 194) and 308 RC (II 124, III 84). Median age: 62 y (20;79); 352 M/267 F. ChT schedule: 5FU 245 pts(39,6%), 5FU-LV 124 pts (20%), 5FU-Lev 213 pts (34,4%); other 37 pts (6%). 314 pts received radiotherapy: 10 CC and 304 CR (pre/postoperative 82/222). Median follow-up is 66,9 m. Pts to assess: 583 (8 lost and 28 death without relapse). Relapses rate: 35,7%: locoregional (LR) 4,5% (26), sistemic (S) 26,4% (154) and both 4,8% (28). 83,6% of relapses were detected in the early 3 years. The first indicator of relapse was CEA in 57,2%, clinical visit in 14,4%, CT in 10%, abdominal US in 3,8%, chest X-ray in 4,8% and colonoscopy in 1%. In 8.7% pts data was not aviable. Potentially radical surgery was performed in 73 pts (35%): 12 LR(46,2%), 56 S(36,4%) and 5 LR+S (17.9%). 57.6% of the liver relapses as unique metastatic site were resected. All these relapses were detected by CEA in 50,1% and by imaging techniques in 30% as a first indicator. The median survival was 18 m: 62 m for pts with resected relapse and 12,4 m for pts with unresecable relapse (p<0.001). Conclusions: Surveillance imaging techniques are valuable components of postoperative follow-up in stage II and III CCR. No significant financial relationships to disclose." @default.
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• W2589505737 date "2005-06-01" @default.
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• W2589505737 title "Imaging techniques are useful in the surveillance after adjuvant treatment of colorectal cancer (CRC)" @default.
• W2589505737 doi "https://doi.org/10.1200/jco.2005.23.16_suppl.3653" @default.
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