FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2589597594> ?p ?o ?g. }

• W2589597594 endingPage "125" @default.
• W2589597594 startingPage "114" @default.
• W2589597594 abstract "Factor VII (FVII) plays a key role in the initiation of the coagulation cascade and, in clinical situations, recombinant human activated FVII (rFVIIa) effectively prevents progressive hemorrhaging after a brain contusion. However, it remains unclear whether decreases in FVII activity directly lead to progressive hemorrhaging and, moreover, the precise mechanisms underlying this process are not yet known. The present study demonstrated that decreased FVII activity directly led to progressive hemorrhaging of the cerebral contusions. Administration of FVII prevented the progression of hemorrhaging from cerebral contusions by protecting microvessel endothelial cells in the penumbra of the contusion. The present study also showed that the ternary TF–FVIIa–FXa complex cleaved endogenous protease-activated receptor 2 (PAR2) on endothelial cells, activated the p44/42 mitogen-activated protein kinase (MAPK) signaling cascade, and inhibited p65 nuclear factor-κB (NF-κB) signaling. Furthermore, exposure to ternary TF–FVIIa–FXa protected endothelial cells from thrombin- or inflammatory cytokine-induced apoptosis. Although activation of the p44/42 MAPK signaling pathway is endothelial cell protein C receptor (EPCR)-dependent, inhibition of the p65 NF-κB signaling pathway is EPCR-independent; thus, the regulation mechanism underlying the effects of TF–FVIIa–FXa in vascular endothelial cells appears to be multiple signaling pathways. In summary, the present findings demonstrated that FVIIa prevented the progressive hemorrhaging of brain contusions by protecting microvessel endothelial cells via the formation of the ternary TF–FVIIa–FXa complex. These findings are novel and of great clinical significance because FVIIa is used to prevent the progressive hemorrhaging of brain contusions in humans." @default.
• W2589597594 created "2017-03-03" @default.
• W2589597594 creator A5005164003 @default.
• W2589597594 creator A5011963214 @default.
• W2589597594 creator A5018558120 @default.
• W2589597594 creator A5037331698 @default.
• W2589597594 creator A5054871862 @default.
• W2589597594 creator A5062877600 @default.
• W2589597594 creator A5066315133 @default.
• W2589597594 creator A5075442335 @default.
• W2589597594 creator A5081785928 @default.
• W2589597594 creator A5082594566 @default.
• W2589597594 creator A5084749450 @default.
• W2589597594 date "2017-04-01" @default.
• W2589597594 modified "2023-10-15" @default.
• W2589597594 title "FVIIa prevents the progressive hemorrhaging of a brain contusion by protecting microvessels via formation of the TF–FVIIa–FXa complex" @default.
• W2589597594 cites W1924957067 @default.
• W2589597594 cites W1968715313 @default.
• W2589597594 cites W1973511791 @default.
• W2589597594 cites W1980433728 @default.
• W2589597594 cites W1982312219 @default.
• W2589597594 cites W1985407614 @default.
• W2589597594 cites W1991355960 @default.
• W2589597594 cites W2014164476 @default.
• W2589597594 cites W2030861304 @default.
• W2589597594 cites W2032753317 @default.
• W2589597594 cites W2035363671 @default.
• W2589597594 cites W2037103210 @default.
• W2589597594 cites W2037637421 @default.
• W2589597594 cites W2041404288 @default.
• W2589597594 cites W2047688072 @default.
• W2589597594 cites W2054242328 @default.
• W2589597594 cites W2055868352 @default.
• W2589597594 cites W2058157135 @default.
• W2589597594 cites W2058252463 @default.
• W2589597594 cites W2062396905 @default.
• W2589597594 cites W2067497860 @default.
• W2589597594 cites W2069313943 @default.
• W2589597594 cites W2069891891 @default.
• W2589597594 cites W2080846452 @default.
• W2589597594 cites W2085562583 @default.
• W2589597594 cites W2087677741 @default.
• W2589597594 cites W2101551122 @default.
• W2589597594 cites W2122643422 @default.
• W2589597594 cites W2140951756 @default.
• W2589597594 cites W2148127512 @default.
• W2589597594 cites W2153423854 @default.
• W2589597594 cites W2165271409 @default.
• W2589597594 cites W2402566963 @default.
• W2589597594 doi "https://doi.org/10.1016/j.neuroscience.2017.02.020" @default.
• W2589597594 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28223242" @default.
• W2589597594 hasPublicationYear "2017" @default.
• W2589597594 type Work @default.
• W2589597594 sameAs 2589597594 @default.
• W2589597594 citedByCount "10" @default.
• W2589597594 countsByYear W25895975942018 @default.
• W2589597594 countsByYear W25895975942019 @default.
• W2589597594 countsByYear W25895975942020 @default.
• W2589597594 countsByYear W25895975942021 @default.
• W2589597594 crossrefType "journal-article" @default.
• W2589597594 hasAuthorship W2589597594A5005164003 @default.
• W2589597594 hasAuthorship W2589597594A5011963214 @default.
• W2589597594 hasAuthorship W2589597594A5018558120 @default.
• W2589597594 hasAuthorship W2589597594A5037331698 @default.
• W2589597594 hasAuthorship W2589597594A5054871862 @default.
• W2589597594 hasAuthorship W2589597594A5062877600 @default.
• W2589597594 hasAuthorship W2589597594A5066315133 @default.
• W2589597594 hasAuthorship W2589597594A5075442335 @default.
• W2589597594 hasAuthorship W2589597594A5081785928 @default.
• W2589597594 hasAuthorship W2589597594A5082594566 @default.
• W2589597594 hasAuthorship W2589597594A5084749450 @default.
• W2589597594 hasConcept C123012128 @default.
• W2589597594 hasConcept C126322002 @default.
• W2589597594 hasConcept C181199279 @default.
• W2589597594 hasConcept C185592680 @default.
• W2589597594 hasConcept C186738567 @default.
• W2589597594 hasConcept C202751555 @default.
• W2589597594 hasConcept C203014093 @default.
• W2589597594 hasConcept C2776436680 @default.
• W2589597594 hasConcept C2777292125 @default.
• W2589597594 hasConcept C2778382381 @default.
• W2589597594 hasConcept C2780394083 @default.
• W2589597594 hasConcept C502942594 @default.
• W2589597594 hasConcept C55493867 @default.
• W2589597594 hasConcept C57074206 @default.
• W2589597594 hasConcept C62478195 @default.
• W2589597594 hasConcept C71924100 @default.
• W2589597594 hasConcept C86756495 @default.
• W2589597594 hasConcept C86803240 @default.
• W2589597594 hasConcept C89560881 @default.
• W2589597594 hasConcept C95444343 @default.
• W2589597594 hasConcept C98274493 @default.
• W2589597594 hasConceptScore W2589597594C123012128 @default.
• W2589597594 hasConceptScore W2589597594C126322002 @default.
• W2589597594 hasConceptScore W2589597594C181199279 @default.
• W2589597594 hasConceptScore W2589597594C185592680 @default.
• W2589597594 hasConceptScore W2589597594C186738567 @default.
• W2589597594 hasConceptScore W2589597594C202751555 @default.

• next