FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2589623897> ?p ?o ?g. }

• W2589623897 endingPage "3806" @default.
• W2589623897 startingPage "3797" @default.
• W2589623897 abstract "Metastases remain the major cause of death from cancer. Recent molecular advances have highlighted the importance of metabolic alterations in cancer cells, including the Warburg effect that describes an increased glycolysis in cancer cells. However, how this altered metabolism contributes to tumour metastasis remains elusive. Here, we report that phosphorylation-induced activation of lactate dehydrogenase A (LDHA), an enzyme that catalyses the interconversion of pyruvate and lactate, promotes cancer cell invasion, anoikis resistance and tumour metastasis. We demonstrate that LDHA is phosphorylated at tyrosine 10 by upstream kinases, HER2 and Src. Targeting HER2 or Src attenuated LDH activity as well as invasive potential in head and neck cancer and breast cancer cells. Inhibition of LDH activity by small hairpin ribonucleic acid or expression of phospho-deficient LDHA Y10F sensitized the cancer cells to anoikis induction and resulted in attenuated cell invasion and elevated reactive oxygen species, whereas such phenotypes were reversed by its product lactate or antioxidant N-acetylcysteine, suggesting that Y10 phosphorylation-mediated LDHA activity promotes cancer cell invasion and anoikis resistance through redox homeostasis. In addition, LDHA knockdown or LDHA Y10F rescue expression in human cancer cells resulted in decreased tumour metastasis in xenograft mice. Furthermore, LDHA phosphorylation at Y10 positively correlated with progression of metastatic breast cancer in clinical patient tumour samples. Our findings demonstrate that LDHA phosphorylation and activation provide pro-invasive, anti-anoikis and pro-metastatic advantages to cancer cells, suggesting that Y10 phosphorylation of LDHA may represent a promising therapeutic target and a prognostic marker for metastatic human cancers." @default.
• W2589623897 created "2017-03-03" @default.
• W2589623897 creator A5002843932 @default.
• W2589623897 creator A5010399375 @default.
• W2589623897 creator A5022690335 @default.
• W2589623897 creator A5037904476 @default.
• W2589623897 creator A5046534881 @default.
• W2589623897 creator A5046605986 @default.
• W2589623897 creator A5051036375 @default.
• W2589623897 creator A5059710197 @default.
• W2589623897 creator A5066168392 @default.
• W2589623897 creator A5069105498 @default.
• W2589623897 creator A5076475259 @default.
• W2589623897 creator A5081860481 @default.
• W2589623897 date "2017-02-20" @default.
• W2589623897 modified "2023-10-16" @default.
• W2589623897 title "Phosphorylation-mediated activation of LDHA promotes cancer cell invasion and tumour metastasis" @default.
• W2589623897 cites W1520425169 @default.
• W2589623897 cites W1559021784 @default.
• W2589623897 cites W1574675143 @default.
• W2589623897 cites W1757875555 @default.
• W2589623897 cites W1818470125 @default.
• W2589623897 cites W1964959571 @default.
• W2589623897 cites W1966447268 @default.
• W2589623897 cites W1967229546 @default.
• W2589623897 cites W1972812075 @default.
• W2589623897 cites W1973568716 @default.
• W2589623897 cites W1979729004 @default.
• W2589623897 cites W1986471913 @default.
• W2589623897 cites W1991429659 @default.
• W2589623897 cites W1992746048 @default.
• W2589623897 cites W2003472128 @default.
• W2589623897 cites W2005833897 @default.
• W2589623897 cites W2009999719 @default.
• W2589623897 cites W2015449504 @default.
• W2589623897 cites W2015674248 @default.
• W2589623897 cites W2038009564 @default.
• W2589623897 cites W2039251470 @default.
• W2589623897 cites W2041024692 @default.
• W2589623897 cites W2061708936 @default.
• W2589623897 cites W2062249523 @default.
• W2589623897 cites W2064972175 @default.
• W2589623897 cites W2067014191 @default.
• W2589623897 cites W2076797886 @default.
• W2589623897 cites W2086641174 @default.
• W2589623897 cites W2090438628 @default.
• W2589623897 cites W2093921289 @default.
• W2589623897 cites W2100260504 @default.
• W2589623897 cites W2101075480 @default.
• W2589623897 cites W2108426094 @default.
• W2589623897 cites W2108718020 @default.
• W2589623897 cites W2109609800 @default.
• W2589623897 cites W2110617603 @default.
• W2589623897 cites W2116403488 @default.
• W2589623897 cites W2121630405 @default.
• W2589623897 cites W2127927539 @default.
• W2589623897 cites W2137022580 @default.
• W2589623897 cites W2138333784 @default.
• W2589623897 cites W2144744111 @default.
• W2589623897 cites W2158517181 @default.
• W2589623897 cites W2161463252 @default.
• W2589623897 cites W2163471981 @default.
• W2589623897 cites W2165200432 @default.
• W2589623897 cites W2338481647 @default.
• W2589623897 cites W2340010580 @default.
• W2589623897 cites W2342510521 @default.
• W2589623897 cites W2411722040 @default.
• W2589623897 cites W271842122 @default.
• W2589623897 doi "https://doi.org/10.1038/onc.2017.6" @default.
• W2589623897 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5501759" @default.
• W2589623897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28218905" @default.
• W2589623897 hasPublicationYear "2017" @default.
• W2589623897 type Work @default.
• W2589623897 sameAs 2589623897 @default.
• W2589623897 citedByCount "172" @default.
• W2589623897 countsByYear W25896238972017 @default.
• W2589623897 countsByYear W25896238972018 @default.
• W2589623897 countsByYear W25896238972019 @default.
• W2589623897 countsByYear W25896238972020 @default.
• W2589623897 countsByYear W25896238972021 @default.
• W2589623897 countsByYear W25896238972022 @default.
• W2589623897 countsByYear W25896238972023 @default.
• W2589623897 crossrefType "journal-article" @default.
• W2589623897 hasAuthorship W2589623897A5002843932 @default.
• W2589623897 hasAuthorship W2589623897A5010399375 @default.
• W2589623897 hasAuthorship W2589623897A5022690335 @default.
• W2589623897 hasAuthorship W2589623897A5037904476 @default.
• W2589623897 hasAuthorship W2589623897A5046534881 @default.
• W2589623897 hasAuthorship W2589623897A5046605986 @default.
• W2589623897 hasAuthorship W2589623897A5051036375 @default.
• W2589623897 hasAuthorship W2589623897A5059710197 @default.
• W2589623897 hasAuthorship W2589623897A5066168392 @default.
• W2589623897 hasAuthorship W2589623897A5069105498 @default.
• W2589623897 hasAuthorship W2589623897A5076475259 @default.
• W2589623897 hasAuthorship W2589623897A5081860481 @default.
• W2589623897 hasBestOaLocation W25896238972 @default.
• W2589623897 hasConcept C109156525 @default.
• W2589623897 hasConcept C11960822 @default.

• next