FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2589631261> ?p ?o ?g. }

• W2589631261 endingPage "682" @default.
• W2589631261 startingPage "674" @default.
• W2589631261 abstract "Although the link between vigabatrin (VGB) and retinotoxicity is well known, little attention has been focused on the risk of VGB-associated brain abnormalities on magnetic resonance imaging (MRI) (VABAM), namely reversible-and largely asymptomatic-signal changes in the thalami, basal ganglia, brainstem tegmentum, and cerebellar nuclei. Using a large infantile spasms cohort, we set out to identify predictors of these phenomena.Children with infantile spasms were retrospectively identified. Brain MRI reports were serially reviewed without knowledge of VGB exposure. Upon VABAM discovery, records were systematically reviewed to ascertain presence of symptoms attributable to VGB. Separately, progress notes were sequentially reviewed to identify and quantify VGB exposure.We identified 507 brain MRI studies among 257 patients with infantile spasms. VGB treatment was documented in 143 children, with detailed exposure data available for 104, of whom 45 had at least one MRI study during VGB treatment. Among the limited subset of asymptomatic children who underwent MRI (n = 40), 6 exhibited VABAM. Risk of asymptomatic VABAM was dose-dependent, as peak (but not cumulative) VGB dosage was strongly associated with asymptomatic VABAM (p = 0.0028). In an exploratory analysis, we encountered 4 children with symptomatic VABAM among 104 patients with detailed VGB exposure data. Risk of symptomatic VABAM was seemingly dose-independent, and potentially associated with concomitant hormonal therapy (i.e., prednisolone and adrenocorticotropic hormone [ACTH]) (p = 0.039).We have demonstrated dose-dependent risk of asymptomatic VABAM and uncovered a possible association between symptomatic VABAM and concomitant hormonal therapy. Caution should be exercised in the use of high VGB dosage (i.e., >175 mg/kg/day), and further study is warranted to confirm the potential impact of hormonal therapy." @default.
• W2589631261 created "2017-03-03" @default.
• W2589631261 creator A5017671349 @default.
• W2589631261 creator A5021314819 @default.
• W2589631261 creator A5028623947 @default.
• W2589631261 creator A5045343636 @default.
• W2589631261 creator A5071776943 @default.
• W2589631261 creator A5072730537 @default.
• W2589631261 creator A5080180891 @default.
• W2589631261 creator A5088223126 @default.
• W2589631261 date "2017-02-23" @default.
• W2589631261 modified "2023-10-14" @default.
• W2589631261 title "Risk of vigabatrin‐associated brain abnormalities on <scp>MRI</scp> in the treatment of infantile spasms is dose‐dependent" @default.
• W2589631261 cites W1514107548 @default.
• W2589631261 cites W1573763499 @default.
• W2589631261 cites W1575745249 @default.
• W2589631261 cites W1594274983 @default.
• W2589631261 cites W1948601338 @default.
• W2589631261 cites W1963519141 @default.
• W2589631261 cites W1984389146 @default.
• W2589631261 cites W1997190808 @default.
• W2589631261 cites W2001118732 @default.
• W2589631261 cites W2006734991 @default.
• W2589631261 cites W2019317759 @default.
• W2589631261 cites W2024975735 @default.
• W2589631261 cites W2037122149 @default.
• W2589631261 cites W2043781797 @default.
• W2589631261 cites W2050058215 @default.
• W2589631261 cites W2060806258 @default.
• W2589631261 cites W2067672673 @default.
• W2589631261 cites W2083563713 @default.
• W2589631261 cites W2095185628 @default.
• W2589631261 cites W2099478180 @default.
• W2589631261 cites W2125508519 @default.
• W2589631261 cites W2128250146 @default.
• W2589631261 cites W2133572298 @default.
• W2589631261 cites W2143697715 @default.
• W2589631261 cites W2164166856 @default.
• W2589631261 cites W2171386011 @default.
• W2589631261 cites W2281671491 @default.
• W2589631261 cites W2437678784 @default.
• W2589631261 cites W2552835369 @default.
• W2589631261 doi "https://doi.org/10.1111/epi.13712" @default.
• W2589631261 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28230253" @default.
• W2589631261 hasPublicationYear "2017" @default.
• W2589631261 type Work @default.
• W2589631261 sameAs 2589631261 @default.
• W2589631261 citedByCount "46" @default.
• W2589631261 countsByYear W25896312612017 @default.
• W2589631261 countsByYear W25896312612018 @default.
• W2589631261 countsByYear W25896312612019 @default.
• W2589631261 countsByYear W25896312612020 @default.
• W2589631261 countsByYear W25896312612021 @default.
• W2589631261 countsByYear W25896312612022 @default.
• W2589631261 countsByYear W25896312612023 @default.
• W2589631261 crossrefType "journal-article" @default.
• W2589631261 hasAuthorship W2589631261A5017671349 @default.
• W2589631261 hasAuthorship W2589631261A5021314819 @default.
• W2589631261 hasAuthorship W2589631261A5028623947 @default.
• W2589631261 hasAuthorship W2589631261A5045343636 @default.
• W2589631261 hasAuthorship W2589631261A5071776943 @default.
• W2589631261 hasAuthorship W2589631261A5072730537 @default.
• W2589631261 hasAuthorship W2589631261A5080180891 @default.
• W2589631261 hasAuthorship W2589631261A5088223126 @default.
• W2589631261 hasBestOaLocation W25896312611 @default.
• W2589631261 hasConcept C118552586 @default.
• W2589631261 hasConcept C126322002 @default.
• W2589631261 hasConcept C126838900 @default.
• W2589631261 hasConcept C143409427 @default.
• W2589631261 hasConcept C187212893 @default.
• W2589631261 hasConcept C2775858608 @default.
• W2589631261 hasConcept C2777910003 @default.
• W2589631261 hasConcept C2778186239 @default.
• W2589631261 hasConcept C2778201146 @default.
• W2589631261 hasConcept C2779888125 @default.
• W2589631261 hasConcept C2780837902 @default.
• W2589631261 hasConcept C71924100 @default.
• W2589631261 hasConcept C72563966 @default.
• W2589631261 hasConceptScore W2589631261C118552586 @default.
• W2589631261 hasConceptScore W2589631261C126322002 @default.
• W2589631261 hasConceptScore W2589631261C126838900 @default.
• W2589631261 hasConceptScore W2589631261C143409427 @default.
• W2589631261 hasConceptScore W2589631261C187212893 @default.
• W2589631261 hasConceptScore W2589631261C2775858608 @default.
• W2589631261 hasConceptScore W2589631261C2777910003 @default.
• W2589631261 hasConceptScore W2589631261C2778186239 @default.
• W2589631261 hasConceptScore W2589631261C2778201146 @default.
• W2589631261 hasConceptScore W2589631261C2779888125 @default.
• W2589631261 hasConceptScore W2589631261C2780837902 @default.
• W2589631261 hasConceptScore W2589631261C71924100 @default.
• W2589631261 hasConceptScore W2589631261C72563966 @default.
• W2589631261 hasFunder F4320306432 @default.
• W2589631261 hasFunder F4320306781 @default.
• W2589631261 hasFunder F4320311407 @default.
• W2589631261 hasFunder F4320322148 @default.
• W2589631261 hasFunder F4320332161 @default.
• W2589631261 hasIssue "4" @default.
• W2589631261 hasLocation W25896312611 @default.

• next