Matches in SemOpenAlex for { <https://semopenalex.org/work/W2589672461> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2589672461 endingPage "305" @default.
- W2589672461 startingPage "305" @default.
- W2589672461 abstract "305 Background: Pancreatic adenocarcinoma (PAC) remains a devastating malignancy and the role for preoperative radiation therapy (prRT) remains uncertain. This analysis used the National Cancer Data Base (NCDB) to report outcomes for the largest known retrospective cohort of patients treated with prRT for resectable PAC to date. Methods: NCDB data were obtained for all patients who underwent resection and RT for PAC from 1998-2002. Patients with metastatic (M1) disease, combined prRT and poRT, missing OS or missing RT variables were excluded. The difference in patients’ characteristics was assessed by a Chi-square test and ANOVA. The Kaplan-Meier method was used to estimate overall survival (OS); survival differences were assessed using a log-rank test. A Cox proportional hazards model was used for unadjusted and multivariable (MV) survival analysis. Two MV logistic regression models also were used to assess for differences in margin status and lymph node (LN) status across treatment groups. Results: 5,414 analyzable patients were identified. 5.1% (277/5,414) received prRT and 94.9% (5,137/5,414) received poRT. All patients underwent resection and prRT or poRT +/- chemotherapy; 92.9% chemo. 793 patients were AJCC 5 th edition stage I, 1,002 stage II, 2,990 were stage III, and 522 were stage IVa; 107 patients were M0 with unknown overall stage. There was no significant difference in OS between the two groups on unadjusted Kaplan-Meier analysis. In covariate-adjusted analysis, there was no significant difference in OS in the prRT (HR, 1.20 [95% CI .98-1.48]; p = 0.08) compared with poRT; prRT was associated with lower rates of LN positivity (OR, 0.45 [95% CI 0.31-0.65]; p < 0.001) and higher rates of negative margins (OR 1.71 [95% CI 1.17-2.52]; p = 0.006). Conclusions: In the largest published series of prRT patients to date, prRT was associated with negative margins and LN negativity at resection. There was no significant difference in OS between the groups. Limitations of this study include its retrospective nature, a small prRT cohort and lack of comorbidity data. These data may be useful in generating future prospective studies of prRT for PAC." @default.
- W2589672461 created "2017-03-03" @default.
- W2589672461 creator A5003655579 @default.
- W2589672461 creator A5006174923 @default.
- W2589672461 creator A5014194325 @default.
- W2589672461 creator A5024809460 @default.
- W2589672461 creator A5029089899 @default.
- W2589672461 creator A5043541884 @default.
- W2589672461 creator A5055989413 @default.
- W2589672461 creator A5056296628 @default.
- W2589672461 creator A5065088834 @default.
- W2589672461 creator A5065934113 @default.
- W2589672461 date "2013-02-01" @default.
- W2589672461 modified "2023-09-26" @default.
- W2589672461 title "Radiation therapy sequencing for resected pancreatic adenocarcinoma in the National Cancer Data Base: A multi-institutional comparative analysis." @default.
- W2589672461 doi "https://doi.org/10.1200/jco.2013.31.4_suppl.305" @default.
- W2589672461 hasPublicationYear "2013" @default.
- W2589672461 type Work @default.
- W2589672461 sameAs 2589672461 @default.
- W2589672461 citedByCount "0" @default.
- W2589672461 crossrefType "journal-article" @default.
- W2589672461 hasAuthorship W2589672461A5003655579 @default.
- W2589672461 hasAuthorship W2589672461A5006174923 @default.
- W2589672461 hasAuthorship W2589672461A5014194325 @default.
- W2589672461 hasAuthorship W2589672461A5024809460 @default.
- W2589672461 hasAuthorship W2589672461A5029089899 @default.
- W2589672461 hasAuthorship W2589672461A5043541884 @default.
- W2589672461 hasAuthorship W2589672461A5055989413 @default.
- W2589672461 hasAuthorship W2589672461A5056296628 @default.
- W2589672461 hasAuthorship W2589672461A5065088834 @default.
- W2589672461 hasAuthorship W2589672461A5065934113 @default.
- W2589672461 hasConcept C10515644 @default.
- W2589672461 hasConcept C121608353 @default.
- W2589672461 hasConcept C126322002 @default.
- W2589672461 hasConcept C141071460 @default.
- W2589672461 hasConcept C143998085 @default.
- W2589672461 hasConcept C146357865 @default.
- W2589672461 hasConcept C151730666 @default.
- W2589672461 hasConcept C207103383 @default.
- W2589672461 hasConcept C2780210213 @default.
- W2589672461 hasConcept C2781182431 @default.
- W2589672461 hasConcept C44249647 @default.
- W2589672461 hasConcept C50382708 @default.
- W2589672461 hasConcept C66339696 @default.
- W2589672461 hasConcept C71924100 @default.
- W2589672461 hasConcept C72563966 @default.
- W2589672461 hasConcept C86803240 @default.
- W2589672461 hasConceptScore W2589672461C10515644 @default.
- W2589672461 hasConceptScore W2589672461C121608353 @default.
- W2589672461 hasConceptScore W2589672461C126322002 @default.
- W2589672461 hasConceptScore W2589672461C141071460 @default.
- W2589672461 hasConceptScore W2589672461C143998085 @default.
- W2589672461 hasConceptScore W2589672461C146357865 @default.
- W2589672461 hasConceptScore W2589672461C151730666 @default.
- W2589672461 hasConceptScore W2589672461C207103383 @default.
- W2589672461 hasConceptScore W2589672461C2780210213 @default.
- W2589672461 hasConceptScore W2589672461C2781182431 @default.
- W2589672461 hasConceptScore W2589672461C44249647 @default.
- W2589672461 hasConceptScore W2589672461C50382708 @default.
- W2589672461 hasConceptScore W2589672461C66339696 @default.
- W2589672461 hasConceptScore W2589672461C71924100 @default.
- W2589672461 hasConceptScore W2589672461C72563966 @default.
- W2589672461 hasConceptScore W2589672461C86803240 @default.
- W2589672461 hasIssue "4_suppl" @default.
- W2589672461 hasLocation W25896724611 @default.
- W2589672461 hasOpenAccess W2589672461 @default.
- W2589672461 hasPrimaryLocation W25896724611 @default.
- W2589672461 hasRelatedWork W2080671488 @default.
- W2589672461 hasRelatedWork W2128245076 @default.
- W2589672461 hasRelatedWork W2143758437 @default.
- W2589672461 hasRelatedWork W2558534037 @default.
- W2589672461 hasRelatedWork W2760851598 @default.
- W2589672461 hasRelatedWork W2962919101 @default.
- W2589672461 hasRelatedWork W3113787349 @default.
- W2589672461 hasRelatedWork W3165794028 @default.
- W2589672461 hasRelatedWork W4243228041 @default.
- W2589672461 hasRelatedWork W4292448967 @default.
- W2589672461 hasVolume "31" @default.
- W2589672461 isParatext "false" @default.
- W2589672461 isRetracted "false" @default.
- W2589672461 magId "2589672461" @default.
- W2589672461 workType "article" @default.