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• W2589746596 abstract "ContextAdults with venous leg ulcers frequently experience multiple symptoms which may influence quality of life (QOL).ObjectivesTo identify patient subgroups based on their experience with a pain-depression-fatigue-sleep disturbance (PDFS) symptom cluster and to identify differences in patient characteristics, as well as wound healing and quality of life outcomes between the subgroups.MethodsSecondary data analysis from previous longitudinal studies of 247 patients with venous leg ulcers. Latent class analysis (LCA) identified subgroups of patients with distinct experiences with the symptom cluster of pain, depression, fatigue, and sleep disturbance. Hierarchical regression analysis identified relationships between the subgroups and QOL outcomes. Survival analysis identified differences between the subgroups and ulcer healing.ResultsLCA found 67% of patients were in a mild symptom subgroup, (i.e., experiencing no or mild pain, depressive symptoms, fatigue, or sleep disturbance). One-third of the sample were in a severe symptom subgroup, who reported moderate to severe levels of these symptoms. Compared to the mild subgroup,, patients in the severe subgroup had poorer QOL scores (t=8.06, p<0.001). Symptom subgroup membership accounted for 19% of the variance (p<0.001) within a hierarchical regression model that explained 42% of the variance in QOL (F(7,170)=16.89, p<0.001, R2=.42). Cox proportional hazards regression found that at enrolment into the study, patients in the severe symptom subgroup were 1.5 times (95%CI 1.02–2.08) less likely to heal in the following 24 weeks (p=0.037).ConclusionSignificant relationships were found between delayed ulcer healing, decreased QOL, and membership in the severe symptom subgroup. These findings suggest that comprehensive symptom assessment is needed to identify patients at higher risk for poor outcomes and enable early intervention.Keywords venous leg ulcers; quality of life; healing; symptom cluster; pain; fatigue" @default.
• W2589746596 created "2017-03-03" @default.
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• W2589746596 date "2017-01-01" @default.
• W2589746596 modified "2023-09-28" @default.
• W2589746596 title "Distinct wound healing and quality of life outcomes in subgroups of patients with venous leg ulcers with different symptom cluster experiences" @default.
• W2589746596 hasPublicationYear "2017" @default.
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