Matches in SemOpenAlex for { <https://semopenalex.org/work/W2589767514> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2589767514 abstract "Celecoxib (CXB) has been explored as an anti-inflammatory or chemopreventive drug for topical treatment of skin diseases and cancer.The main aim of this work was to investigate the potential of dimethylsufoxide (DMSO) and Azone (AZ) as penetration enhancers (P.Es) for topical delivery of CXB.The in vitro studies, drug release, skin permeability and potential cytotoxicity/genotoxicity were carried out with formulations containing or not DMSO or AZ (5% and 10%). Skin irritation in rabbits and topical anti-inflammatory activity in mice were assayed in vivo.Skin permeation was minimal while higher retention in stratum corneum (SC) and epidermis plus dermis was found (28.0 and 3-fold respectively) from 10.0% AZ compared to the control indicating a localized CXB effect. CXB associated to 5% or 10% DMSO has shown high drug permeation through skin with low retention. Associations of CXB with both enhancers were not cytotoxic or genotoxic, suggesting safety for cutaneous application. In vivo skin irritation assays of all formulations indicated mild irritation effects and, thus, possible use for longer periods. In vivo anti-inflammatory tests showed that ear edema could be inhibited by CXB associated with 5.0% DMSO (53.0%) or 10.0% AZ (40.0%). These inhibition values were almost 2-fold higher when compared to a commercial formula.Although DMSO- associated CXB is an efficient edema inhibitor its high skin permeation suggests risks of systemic effects, whereas association to 10% AZ may improve topical delivery of the drug with good anti-inflammatory activity and no cytotoxic/genotoxic or significant skin irritation effects." @default.
- W2589767514 created "2017-03-03" @default.
- W2589767514 creator A5005409939 @default.
- W2589767514 creator A5048473398 @default.
- W2589767514 creator A5049674374 @default.
- W2589767514 creator A5055613549 @default.
- W2589767514 creator A5058106407 @default.
- W2589767514 creator A5071262932 @default.
- W2589767514 creator A5083999072 @default.
- W2589767514 creator A5085044859 @default.
- W2589767514 creator A5086420936 @default.
- W2589767514 creator A5086594704 @default.
- W2589767514 date "2017-10-16" @default.
- W2589767514 modified "2023-10-16" @default.
- W2589767514 title "In Vitro and In Vivo Evaluation of DMSO and Azone as Penetration Enhancers for Cutaneous Application of Celecoxib" @default.
- W2589767514 doi "https://doi.org/10.2174/1567201814666170125120331" @default.
- W2589767514 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28124617" @default.
- W2589767514 hasPublicationYear "2017" @default.
- W2589767514 type Work @default.
- W2589767514 sameAs 2589767514 @default.
- W2589767514 citedByCount "4" @default.
- W2589767514 countsByYear W25897675142018 @default.
- W2589767514 countsByYear W25897675142021 @default.
- W2589767514 countsByYear W25897675142022 @default.
- W2589767514 crossrefType "journal-article" @default.
- W2589767514 hasAuthorship W2589767514A5005409939 @default.
- W2589767514 hasAuthorship W2589767514A5048473398 @default.
- W2589767514 hasAuthorship W2589767514A5049674374 @default.
- W2589767514 hasAuthorship W2589767514A5055613549 @default.
- W2589767514 hasAuthorship W2589767514A5058106407 @default.
- W2589767514 hasAuthorship W2589767514A5071262932 @default.
- W2589767514 hasAuthorship W2589767514A5083999072 @default.
- W2589767514 hasAuthorship W2589767514A5085044859 @default.
- W2589767514 hasAuthorship W2589767514A5086420936 @default.
- W2589767514 hasAuthorship W2589767514A5086594704 @default.
- W2589767514 hasConcept C121608353 @default.
- W2589767514 hasConcept C126322002 @default.
- W2589767514 hasConcept C142724271 @default.
- W2589767514 hasConcept C150903083 @default.
- W2589767514 hasConcept C178790620 @default.
- W2589767514 hasConcept C185592680 @default.
- W2589767514 hasConcept C203014093 @default.
- W2589767514 hasConcept C207001950 @default.
- W2589767514 hasConcept C2776005048 @default.
- W2589767514 hasConcept C2776467144 @default.
- W2589767514 hasConcept C2777063393 @default.
- W2589767514 hasConcept C2777624698 @default.
- W2589767514 hasConcept C2777789703 @default.
- W2589767514 hasConcept C2778370115 @default.
- W2589767514 hasConcept C2778959862 @default.
- W2589767514 hasConcept C29730261 @default.
- W2589767514 hasConcept C41625074 @default.
- W2589767514 hasConcept C50670333 @default.
- W2589767514 hasConcept C55493867 @default.
- W2589767514 hasConcept C71924100 @default.
- W2589767514 hasConcept C86803240 @default.
- W2589767514 hasConcept C98274493 @default.
- W2589767514 hasConceptScore W2589767514C121608353 @default.
- W2589767514 hasConceptScore W2589767514C126322002 @default.
- W2589767514 hasConceptScore W2589767514C142724271 @default.
- W2589767514 hasConceptScore W2589767514C150903083 @default.
- W2589767514 hasConceptScore W2589767514C178790620 @default.
- W2589767514 hasConceptScore W2589767514C185592680 @default.
- W2589767514 hasConceptScore W2589767514C203014093 @default.
- W2589767514 hasConceptScore W2589767514C207001950 @default.
- W2589767514 hasConceptScore W2589767514C2776005048 @default.
- W2589767514 hasConceptScore W2589767514C2776467144 @default.
- W2589767514 hasConceptScore W2589767514C2777063393 @default.
- W2589767514 hasConceptScore W2589767514C2777624698 @default.
- W2589767514 hasConceptScore W2589767514C2777789703 @default.
- W2589767514 hasConceptScore W2589767514C2778370115 @default.
- W2589767514 hasConceptScore W2589767514C2778959862 @default.
- W2589767514 hasConceptScore W2589767514C29730261 @default.
- W2589767514 hasConceptScore W2589767514C41625074 @default.
- W2589767514 hasConceptScore W2589767514C50670333 @default.
- W2589767514 hasConceptScore W2589767514C55493867 @default.
- W2589767514 hasConceptScore W2589767514C71924100 @default.
- W2589767514 hasConceptScore W2589767514C86803240 @default.
- W2589767514 hasConceptScore W2589767514C98274493 @default.
- W2589767514 hasIssue "7" @default.
- W2589767514 hasLocation W25897675141 @default.
- W2589767514 hasLocation W25897675142 @default.
- W2589767514 hasOpenAccess W2589767514 @default.
- W2589767514 hasPrimaryLocation W25897675141 @default.
- W2589767514 hasRelatedWork W1558767696 @default.
- W2589767514 hasRelatedWork W1977393998 @default.
- W2589767514 hasRelatedWork W2031979845 @default.
- W2589767514 hasRelatedWork W2058902945 @default.
- W2589767514 hasRelatedWork W2077763483 @default.
- W2589767514 hasRelatedWork W2589767514 @default.
- W2589767514 hasRelatedWork W2766109325 @default.
- W2589767514 hasRelatedWork W3168158850 @default.
- W2589767514 hasRelatedWork W3187396610 @default.
- W2589767514 hasRelatedWork W58900999 @default.
- W2589767514 hasVolume "14" @default.
- W2589767514 isParatext "false" @default.
- W2589767514 isRetracted "false" @default.
- W2589767514 magId "2589767514" @default.
- W2589767514 workType "article" @default.