Matches in SemOpenAlex for { <https://semopenalex.org/work/W2589769884> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2589769884 abstract "Gold nanoparticles (AuNPs) were recently reported to increase ionization of biomolecules in Matrix-Assisted Laser Desorption Ionization Time-Of-Flight (MALDI-TOF) Mass Spectrometry (MS) of complex biological samples, such as cells and tissues.[1-2] In this setup, the matrix-sample mixture is enriched with AuNPs of various size and geometry that most probably enhance distribution of laser energy throughout the sample and facilitate ionization and/or quantum nano-plasmons effects during the process of measurements. We asked, whether AuNPs endocyted by cultured cells can enhance subsequent MS analysis. In this work, we treated HEK293 cells with either polyhedral or flower-like AuNPs or left them untreated and cultured them overnight. Then the cells were washed, harvested, mixed with matrix and directly analyzed by MS. Both the polyhedral and flower-like AuNPs were massively endocyted by HEK293 cells. The mass spectra acquired from intact cells containing endocyted AuNPs showed an increase of intensity of specific peaks. Interestingly, mass spectra generated from intact cells containing polyhedral or flower-like AuNPs showed differences in m/z or intensity values, suggesting selective effect of AuNPs structure on cell targets. The endocyted nanoparticles can interact with various components of cellular metabolism. The interactions of AuNPs with biomolecular pool in living cells can therefore extend the analytical approaches such as MALDI, SALDI (Surface Assisted Laser Desorption Ionization) or NALDI (Nano Particles Assisted Laser Desorption Ionization) used in intact cell MS." @default.
- W2589769884 created "2017-03-03" @default.
- W2589769884 creator A5000666589 @default.
- W2589769884 creator A5045445092 @default.
- W2589769884 creator A5049557870 @default.
- W2589769884 creator A5063082516 @default.
- W2589769884 creator A5073970506 @default.
- W2589769884 creator A5087453370 @default.
- W2589769884 creator A5088395031 @default.
- W2589769884 date "2015-04-23" @default.
- W2589769884 modified "2023-09-27" @default.
- W2589769884 title "Endocyted gold-nanoparticles in intact-cell mass spectrometry" @default.
- W2589769884 hasPublicationYear "2015" @default.
- W2589769884 type Work @default.
- W2589769884 sameAs 2589769884 @default.
- W2589769884 citedByCount "0" @default.
- W2589769884 crossrefType "journal-article" @default.
- W2589769884 hasAuthorship W2589769884A5000666589 @default.
- W2589769884 hasAuthorship W2589769884A5045445092 @default.
- W2589769884 hasAuthorship W2589769884A5049557870 @default.
- W2589769884 hasAuthorship W2589769884A5063082516 @default.
- W2589769884 hasAuthorship W2589769884A5073970506 @default.
- W2589769884 hasAuthorship W2589769884A5087453370 @default.
- W2589769884 hasAuthorship W2589769884A5088395031 @default.
- W2589769884 hasConcept C104819515 @default.
- W2589769884 hasConcept C106487976 @default.
- W2589769884 hasConcept C113196181 @default.
- W2589769884 hasConcept C145148216 @default.
- W2589769884 hasConcept C150394285 @default.
- W2589769884 hasConcept C155672457 @default.
- W2589769884 hasConcept C162356407 @default.
- W2589769884 hasConcept C162711632 @default.
- W2589769884 hasConcept C171250308 @default.
- W2589769884 hasConcept C178790620 @default.
- W2589769884 hasConcept C185592680 @default.
- W2589769884 hasConcept C192562407 @default.
- W2589769884 hasConcept C198291218 @default.
- W2589769884 hasConcept C40325409 @default.
- W2589769884 hasConcept C43617362 @default.
- W2589769884 hasConcept C49853544 @default.
- W2589769884 hasConcept C55493867 @default.
- W2589769884 hasConceptScore W2589769884C104819515 @default.
- W2589769884 hasConceptScore W2589769884C106487976 @default.
- W2589769884 hasConceptScore W2589769884C113196181 @default.
- W2589769884 hasConceptScore W2589769884C145148216 @default.
- W2589769884 hasConceptScore W2589769884C150394285 @default.
- W2589769884 hasConceptScore W2589769884C155672457 @default.
- W2589769884 hasConceptScore W2589769884C162356407 @default.
- W2589769884 hasConceptScore W2589769884C162711632 @default.
- W2589769884 hasConceptScore W2589769884C171250308 @default.
- W2589769884 hasConceptScore W2589769884C178790620 @default.
- W2589769884 hasConceptScore W2589769884C185592680 @default.
- W2589769884 hasConceptScore W2589769884C192562407 @default.
- W2589769884 hasConceptScore W2589769884C198291218 @default.
- W2589769884 hasConceptScore W2589769884C40325409 @default.
- W2589769884 hasConceptScore W2589769884C43617362 @default.
- W2589769884 hasConceptScore W2589769884C49853544 @default.
- W2589769884 hasConceptScore W2589769884C55493867 @default.
- W2589769884 hasLocation W25897698841 @default.
- W2589769884 hasOpenAccess W2589769884 @default.
- W2589769884 hasPrimaryLocation W25897698841 @default.
- W2589769884 hasRelatedWork W1940922490 @default.
- W2589769884 hasRelatedWork W1974486085 @default.
- W2589769884 hasRelatedWork W1986415591 @default.
- W2589769884 hasRelatedWork W2005353624 @default.
- W2589769884 hasRelatedWork W2011881552 @default.
- W2589769884 hasRelatedWork W2034849824 @default.
- W2589769884 hasRelatedWork W2068001129 @default.
- W2589769884 hasRelatedWork W2075792215 @default.
- W2589769884 hasRelatedWork W2077694961 @default.
- W2589769884 hasRelatedWork W2159535470 @default.
- W2589769884 hasRelatedWork W2160605172 @default.
- W2589769884 hasRelatedWork W2296645551 @default.
- W2589769884 hasRelatedWork W2314478430 @default.
- W2589769884 hasRelatedWork W2466711314 @default.
- W2589769884 hasRelatedWork W2752428280 @default.
- W2589769884 hasRelatedWork W2888512566 @default.
- W2589769884 hasRelatedWork W2915597456 @default.
- W2589769884 hasRelatedWork W3000134123 @default.
- W2589769884 hasRelatedWork W3008241219 @default.
- W2589769884 hasRelatedWork W3040071002 @default.
- W2589769884 isParatext "false" @default.
- W2589769884 isRetracted "false" @default.
- W2589769884 magId "2589769884" @default.
- W2589769884 workType "article" @default.