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• W2589776963 abstract "Growth hormone (GH) exerts several effects on the skeleton, mediated either directly or indirectly, leading to increased bone formation and resorption rates. Patients with growth hormone deficiency (GHD) of adult onset have decreased bone mineral density (BMD) and increased fracture risk. Some, but not all, studies have found that adults with childhood onset GHD also have lower BMD than healthy controls. Adults with GHD of childhood onset have smaller bone dimensions, leading to possible underestimation of areal BMD (measured by dual energy X-ray absorptiometry), thus potentially confounding the interpretation of densitometric data. Available data suggest that patients with childhood onset GHD are at increased fracture risk. Prospective studies and some clinical trials found that GH replacement for at least 18–24 months leads to increased BMD. Retrospective and prospective data suggest that GH replacement is associated with decreased fracture risk in adults. However, data from randomized clinical trials are lacking." @default.
• W2589776963 created "2017-03-03" @default.
• W2589776963 creator A5046245100 @default.
• W2589776963 date "2017-02-01" @default.
• W2589776963 modified "2023-10-06" @default.
• W2589776963 title "Focus on growth hormone deficiency and bone in adults" @default.
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• W2589776963 doi "https://doi.org/10.1016/j.beem.2017.02.002" @default.
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