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• W2589799707 abstract "11113 Background: Methylated-in-tumor loci (MINTs) are non-coding DNA sequences containing CpG islands. The aim of this preliminary study was to assess presence of aberrant methylation of MINT 17 in primary breast cancer. We hypothesized that MINT 17 methylation index is significantly higher in primary breast tumor tissue than in normal breast tissue. Methods: Paraffin- embedded breast tissues of 42 patients were collected. This selection comprised of 26 breast cancer patients and 16 patients without breast cancer. DNA was isolated from primary tumor tissues, and normal breast epithelia DNA was isolated from non-cancer breast tissue. DNA was subjected to sodium bisulfite modification. Absolute quantitative assessment of methylated alleles (AQAMA) was performed to assess methylation status of MINT 17 by multiplex quantitative methylation-specific PCR. The results were expressed as methylation index (MI): MI=methylated copy number / (Methylated copy number + unmethylated copy number). Medians were compared using Wilcoxon rank sum test. ROC-curve AUC was calculated using logistic regression. Results: Median MI for MINT 17 was significantly higher in tumor tissue than in normal breast epithelia (median MI=0.059 (n=26) vs. 0 (n=16); p=0.0001). MI did not exceed 0.03 in normal epithelia, whereas MI exceeded 0.03 in 77% of the cancer tissues. The AUC for the ROC-curve for MINT 17 methylation as a predictor for cancer was 0.887. Median of MINT 17 MI was significantly higher in ER(+) patients than in ER(−) patients (median MI= 0.315 (n=15) vs. 0.043 (n=9); p=0.033). PR(+) patients had higher median MI than PR(−) patients (median MI 0.313 (n=12) vs. 0.053 (n=13), p=0.055). The AUCs for the ROC-curve for MINT 17 MI as predictor for ER status and PR status was 0.785 and 0.737, respectively. Conclusion: MINT 17 MI is significantly higher in primary breast cancer than in normal breast epithelia, and is an indicator for presence of cancer in breast tissue. MINT 17 MI is related to ER and perhaps PR status in primary breast tumors. No significant financial relationships to disclose." @default.
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• W2589799707 date "2008-05-20" @default.
• W2589799707 modified "2023-10-14" @default.
• W2589799707 title "Assessment of MINT 17 methylation in primary breast cancer and normal breast epithelia: A preliminary study" @default.
• W2589799707 doi "https://doi.org/10.1200/jco.2008.26.15_suppl.11113" @default.
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