FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2589807218> ?p ?o ?g. }

• W2589807218 abstract "There is a growing recognition for the need to expand our evidence base for the clinical effectiveness of diagnostic tests. Many international bodies are calling for diagnostic randomized controlled trials to provide the most rigorous evidence of impact to patient health. Although these so-called test-treatment RCTs are very challenging to undertake due to their methodological complexity, they have not been subjected to a systematic appraisal of their methodological quality. The extent to which these trials may be producing biased results therefore remains unknown. We set out to address this issue by conducting a methodological review of published test-treatment trials to determine how often they implement adequate methods to limit bias and safeguard the validity of results. We ascertained all test-treatment RCTs published 2004–2007, indexed in CENTRAL, including RCTs which randomized patients to diagnostic tests and measured patient outcomes after treatment. Tests used for screening, monitoring or prognosis were excluded. We assessed adequacy of sequence generation, allocation concealment and intention-to-treat, appropriateness of primary analyses, blinding and reporting of power calculations, and extracted study characteristics including the primary outcome. One hundred three trials compared 105 control with 119 experimental interventions, and reported 150 primary outcomes. Randomization and allocation concealment were adequate in 57 and 37% of trials. Blinding was uncommon (patients 5%, clinicians 4%, outcome assessors 21%), as was an adequate intention-to-treat analysis (29%). Overall 101 of 103 trials (98%) were at risk of bias, as judged using standard Cochrane criteria. Test-treatment trials are particularly susceptible to attrition and inadequate primary analyses, lack of blinding and under-powering. These weaknesses pose much greater methodological and practical challenges to conducting reliable RCT evaluations of test-treatment strategies than standard treatment interventions. We suggest a cautious approach that first examines whether a test-treatment intervention can accommodate the methodological safeguards necessary to minimize bias, and highlight that test-treatment RCTs require different methods to ensure reliability than standard treatment trials. Please see the companion paper to this article: http://bmcmedresmethodol.biomedcentral.com/articles/10.1186/s12874-016-0286-0 ." @default.
• W2589807218 created "2017-03-03" @default.
• W2589807218 creator A5009420648 @default.
• W2589807218 creator A5020757995 @default.
• W2589807218 creator A5048469910 @default.
• W2589807218 creator A5067817683 @default.
• W2589807218 creator A5071562926 @default.
• W2589807218 date "2017-02-24" @default.
• W2589807218 modified "2023-10-08" @default.
• W2589807218 title "Test-treatment RCTs are susceptible to bias: a review of the methodological quality of randomized trials that evaluate diagnostic tests" @default.
• W2589807218 cites W1932997227 @default.
• W2589807218 cites W1971252299 @default.
• W2589807218 cites W1971606990 @default.
• W2589807218 cites W1978866154 @default.
• W2589807218 cites W1981806974 @default.
• W2589807218 cites W1994158325 @default.
• W2589807218 cites W1996966348 @default.
• W2589807218 cites W2004133899 @default.
• W2589807218 cites W2005725405 @default.
• W2589807218 cites W2006780292 @default.
• W2589807218 cites W2015712245 @default.
• W2589807218 cites W2020460355 @default.
• W2589807218 cites W2021465218 @default.
• W2589807218 cites W2024754236 @default.
• W2589807218 cites W2032541700 @default.
• W2589807218 cites W2033890227 @default.
• W2589807218 cites W2039964888 @default.
• W2589807218 cites W2041033959 @default.
• W2589807218 cites W2046044306 @default.
• W2589807218 cites W2052689199 @default.
• W2589807218 cites W2056772768 @default.
• W2589807218 cites W2065384164 @default.
• W2589807218 cites W2074884761 @default.
• W2589807218 cites W2076682535 @default.
• W2589807218 cites W2078113106 @default.
• W2589807218 cites W2079001968 @default.
• W2589807218 cites W2085500228 @default.
• W2589807218 cites W2085508623 @default.
• W2589807218 cites W2088914278 @default.
• W2589807218 cites W2093186353 @default.
• W2589807218 cites W2111933764 @default.
• W2589807218 cites W2118591160 @default.
• W2589807218 cites W2123125003 @default.
• W2589807218 cites W2124822309 @default.
• W2589807218 cites W2130234665 @default.
• W2589807218 cites W2130692776 @default.
• W2589807218 cites W2134120248 @default.
• W2589807218 cites W2135280905 @default.
• W2589807218 cites W2143638203 @default.
• W2589807218 cites W2147121501 @default.
• W2589807218 cites W2154605990 @default.
• W2589807218 cites W2155000917 @default.
• W2589807218 cites W2156597715 @default.
• W2589807218 cites W2160795579 @default.
• W2589807218 cites W2161167486 @default.
• W2589807218 cites W2167872020 @default.
• W2589807218 cites W2589807218 @default.
• W2589807218 cites W4214559180 @default.
• W2589807218 doi "https://doi.org/10.1186/s12874-016-0287-z" @default.
• W2589807218 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5326492" @default.
• W2589807218 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28236806" @default.
• W2589807218 hasPublicationYear "2017" @default.
• W2589807218 type Work @default.
• W2589807218 sameAs 2589807218 @default.
• W2589807218 citedByCount "23" @default.
• W2589807218 countsByYear W25898072182017 @default.
• W2589807218 countsByYear W25898072182018 @default.
• W2589807218 countsByYear W25898072182019 @default.
• W2589807218 countsByYear W25898072182020 @default.
• W2589807218 countsByYear W25898072182021 @default.
• W2589807218 countsByYear W25898072182022 @default.
• W2589807218 countsByYear W25898072182023 @default.
• W2589807218 crossrefType "journal-article" @default.
• W2589807218 hasAuthorship W2589807218A5009420648 @default.
• W2589807218 hasAuthorship W2589807218A5020757995 @default.
• W2589807218 hasAuthorship W2589807218A5048469910 @default.
• W2589807218 hasAuthorship W2589807218A5067817683 @default.
• W2589807218 hasAuthorship W2589807218A5071562926 @default.
• W2589807218 hasBestOaLocation W25898072181 @default.
• W2589807218 hasConcept C118552586 @default.
• W2589807218 hasConcept C141071460 @default.
• W2589807218 hasConcept C142724271 @default.
• W2589807218 hasConcept C151730666 @default.
• W2589807218 hasConcept C168563851 @default.
• W2589807218 hasConcept C17744445 @default.
• W2589807218 hasConcept C177713679 @default.
• W2589807218 hasConcept C199539241 @default.
• W2589807218 hasConcept C204243189 @default.
• W2589807218 hasConcept C27415008 @default.
• W2589807218 hasConcept C2771230 @default.
• W2589807218 hasConcept C2777267654 @default.
• W2589807218 hasConcept C2779473830 @default.
• W2589807218 hasConcept C49290038 @default.
• W2589807218 hasConcept C535046627 @default.
• W2589807218 hasConcept C71924100 @default.
• W2589807218 hasConcept C86803240 @default.
• W2589807218 hasConceptScore W2589807218C118552586 @default.
• W2589807218 hasConceptScore W2589807218C141071460 @default.
• W2589807218 hasConceptScore W2589807218C142724271 @default.
• W2589807218 hasConceptScore W2589807218C151730666 @default.

• next