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• W2589809323 abstract "9077 Background: Cancer survivors typically experience progressive improvements in HRQOL following initial impairments associated with diagnosis and treatments. As previous studies often focused on cancer-free survivors (CFS), little information is available for non-CFS. We report a comparison of HRQOL of HNC survivors either living with cancer or cancer-free 3 years after RT. Methods: We conducted a randomized trial among 540 patients treated with RT for stage I or II HNC to test whether vitamin E supplementation improved outcomes. We assessed prospectively HRQOL with two validated instruments, the EORTC QLQ-C30 and the Head and Neck Radiotherapy Questionnaire (HNRQ), prior treatment and 3 years after RT. Three years after RT, 416 patients provided HRQOL data. Among them, 85 were non-CFS because they had been diagnosed with a relapse or a second primary cancer (SPC). We used t-tests to compare HRQOL dimensions at baseline and at 3 years between non-CFS and CFS. We also compared their HRQOL changes from baseline to 3 years. Results: At baseline, the HRQOL of future non-CFS and CFS was similar except that future non-CFS experienced more HNRQ throat symptoms (p=0.04). At 3 years, the HRQOL of non-CFS and CFS was also similar except that non-CFS had poorer QLQ-C30 global health status than CFS (p=0.01). Most changes from baseline to 3 years after RT were similar for non-CFS and CFS. There were improvements for emotional and social functioning, sleep and financial difficulties of the QLQ-C30, throat symptoms and psychosocial domain of the HNRQ, while both non-CFS and CFS had increased HNRQ oral cavity and skin symptoms. Few HRQOL changes from baseline to 3 years differed significantly between non-CFS and CFS. Non-CFS experienced a worsening in 4 HRQOL dimensions while CFS showed improvements in these 4 dimensions: global health status (p=0.01), pain (p=0.01) and appetite (p=0.02) of the QLQ-C30 and HNRQ energy (p=0.03). Conclusions: Most changes in HRQOL over the 3 years after RT are similar for CFS and non-CFS. However, patients living with cancer after HNC relapse or SPC experienced increased pain and decreased appetite, global health status and energy while CFS showed improvement in these 4 dimensions." @default.
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• W2589809323 date "2011-05-20" @default.
• W2589809323 modified "2023-09-25" @default.
• W2589809323 title "Health-related quality of life (HRQOL) of patients 3 years after radiation therapy (RT) for early head and neck cancer (HNC)." @default.
• W2589809323 doi "https://doi.org/10.1200/jco.2011.29.15_suppl.9077" @default.
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