FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2590012067> ?p ?o ?g. }

• W2590012067 endingPage "722" @default.
• W2590012067 startingPage "714" @default.
• W2590012067 abstract "The proliferative ability of oligodendrocyte progenitor cells (OPCs) varied markedly under different culture conditions. Astrocytes (ASTs) have been verified to play a major role in regulating the proliferation of OPCs through direct contact. However, the mechanisms have not been fully clarified. To investigate the effect and mechanism under AST and OPC co-culture conditions, we analyzed all connexins comprehensively in OPCs under OPC mono-culture, AST-secreted cell factor co-culture and AST-OPC direct-contact co-culture, and found that significantly differentially expressed Cx47 was the most significant. To assess whether Cx47 plays a role in proliferation, Cx47 siRNA were conducted. The result indicates that the cell cycle of OPCs was changed, and the cell proliferation was markedly inhibited. Kyoto Encyclopedia of Genes and Genomes (KEGG) predictive analysis suggested that Cx47 regulate cell cycle and proliferation by Ca2+ activation of ERK1/2. To verify the prediction, flow cytometry, confocal microscopy, 5-ethynyl-2′-deoxyuridine (EdU), polymerase chain reaction (RT-PCR) and western blot were used. The results show that interference of Cx47 led to decreased Ca2+ concentrations, lower p-ERK 1/2 levels, reduced transcription factor inhibitor of DNA binding 4 (Id4) expression, arrested cell cycle and reduced OPCs proliferative ability. Additionally, blocking ERK1/2 signaling caused decreased Id4 expression, arrested cell cycle in G1 phase, and reduced OPCs proliferative ability. In conclusion, ASTs can cause Ca2+ signaling activation, ERK1/2 phosphorylation, and Id4 expression stimulation in OPCs, inducing proliferation of these cells, mainly through Cx47." @default.
• W2590012067 created "2017-03-03" @default.
• W2590012067 creator A5018426593 @default.
• W2590012067 creator A5026007805 @default.
• W2590012067 creator A5033105884 @default.
• W2590012067 creator A5064946974 @default.
• W2590012067 creator A5067686114 @default.
• W2590012067 creator A5080646722 @default.
• W2590012067 creator A5080683482 @default.
• W2590012067 creator A5085435948 @default.
• W2590012067 creator A5091122351 @default.
• W2590012067 date "2017-03-10" @default.
• W2590012067 modified "2023-10-16" @default.
• W2590012067 title "Astrocytes induce proliferation of oligodendrocyte progenitor cells via connexin 47-mediated activation of the ERK/Id4 pathway" @default.
• W2590012067 cites W1540546146 @default.
• W2590012067 cites W1583048096 @default.
• W2590012067 cites W1678027485 @default.
• W2590012067 cites W1718761190 @default.
• W2590012067 cites W1826494938 @default.
• W2590012067 cites W1901736351 @default.
• W2590012067 cites W1966035296 @default.
• W2590012067 cites W1969438554 @default.
• W2590012067 cites W1977385780 @default.
• W2590012067 cites W1989593333 @default.
• W2590012067 cites W2000838901 @default.
• W2590012067 cites W2006430695 @default.
• W2590012067 cites W2007073406 @default.
• W2590012067 cites W2016703850 @default.
• W2590012067 cites W2019050580 @default.
• W2590012067 cites W2036021978 @default.
• W2590012067 cites W2036518710 @default.
• W2590012067 cites W2041355230 @default.
• W2590012067 cites W2042528531 @default.
• W2590012067 cites W2045814928 @default.
• W2590012067 cites W2059118326 @default.
• W2590012067 cites W2060525739 @default.
• W2590012067 cites W2069611371 @default.
• W2590012067 cites W2080376521 @default.
• W2590012067 cites W2095490681 @default.
• W2590012067 cites W2097790742 @default.
• W2590012067 cites W2107666219 @default.
• W2590012067 cites W2114620478 @default.
• W2590012067 cites W2115716330 @default.
• W2590012067 cites W2125650861 @default.
• W2590012067 cites W2151758299 @default.
• W2590012067 cites W2172326429 @default.
• W2590012067 cites W2295630967 @default.
• W2590012067 cites W2466285782 @default.
• W2590012067 doi "https://doi.org/10.1080/15384101.2017.1295183" @default.
• W2590012067 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5397265" @default.
• W2590012067 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28278052" @default.
• W2590012067 hasPublicationYear "2017" @default.
• W2590012067 type Work @default.
• W2590012067 sameAs 2590012067 @default.
• W2590012067 citedByCount "14" @default.
• W2590012067 countsByYear W25900120672017 @default.
• W2590012067 countsByYear W25900120672018 @default.
• W2590012067 countsByYear W25900120672019 @default.
• W2590012067 countsByYear W25900120672020 @default.
• W2590012067 countsByYear W25900120672021 @default.
• W2590012067 countsByYear W25900120672022 @default.
• W2590012067 countsByYear W25900120672023 @default.
• W2590012067 crossrefType "journal-article" @default.
• W2590012067 hasAuthorship W2590012067A5018426593 @default.
• W2590012067 hasAuthorship W2590012067A5026007805 @default.
• W2590012067 hasAuthorship W2590012067A5033105884 @default.
• W2590012067 hasAuthorship W2590012067A5064946974 @default.
• W2590012067 hasAuthorship W2590012067A5067686114 @default.
• W2590012067 hasAuthorship W2590012067A5080646722 @default.
• W2590012067 hasAuthorship W2590012067A5080683482 @default.
• W2590012067 hasAuthorship W2590012067A5085435948 @default.
• W2590012067 hasAuthorship W2590012067A5091122351 @default.
• W2590012067 hasBestOaLocation W25900120671 @default.
• W2590012067 hasConcept C104317684 @default.
• W2590012067 hasConcept C1491633281 @default.
• W2590012067 hasConcept C150194340 @default.
• W2590012067 hasConcept C152724338 @default.
• W2590012067 hasConcept C153911025 @default.
• W2590012067 hasConcept C162317418 @default.
• W2590012067 hasConcept C169760540 @default.
• W2590012067 hasConcept C201750760 @default.
• W2590012067 hasConcept C2776985911 @default.
• W2590012067 hasConcept C2778609137 @default.
• W2590012067 hasConcept C28328180 @default.
• W2590012067 hasConcept C29537977 @default.
• W2590012067 hasConcept C529278444 @default.
• W2590012067 hasConcept C54355233 @default.
• W2590012067 hasConcept C553184892 @default.
• W2590012067 hasConcept C57074206 @default.
• W2590012067 hasConcept C62112901 @default.
• W2590012067 hasConcept C62478195 @default.
• W2590012067 hasConcept C81885089 @default.
• W2590012067 hasConcept C86803240 @default.
• W2590012067 hasConcept C95444343 @default.
• W2590012067 hasConceptScore W2590012067C104317684 @default.
• W2590012067 hasConceptScore W2590012067C1491633281 @default.
• W2590012067 hasConceptScore W2590012067C150194340 @default.
• W2590012067 hasConceptScore W2590012067C152724338 @default.

• next