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• W2590130519 abstract "The vitamin D receptor (VDR) is a member of the thyroid-steroid family of nuclear transcription factors. Following binding of the active form of vitamin D, i.e., 1,25(OH)2D3 (also known as calcitriol) and interaction with co-activators and co-repressors, VDR regulates the expression of several different genes. Although relatively little work has been carried out on VDR in human cancers, several epidemiological studies suggest that low circulating levels of vitamin D are associated with both an increased risk of developing specific cancer types and poor outcome in patients with specific diagnosed cancers. These associations apply especially in colorectal and breast cancer. Consistent with these findings, calcitriol as well as several of its synthetic analogues have been shown to inhibit tumor cell growth in vitro and in diverse animal model systems. Indeed, some of these vitamin D analogues with low calcemic inducing activity (e.g., EB1089, inecalcitol, paricalcitol) have progressed to clinical trials in patients with cancer. Preliminary results from these trials suggest that these vitamin D analogues have minimal toxicity, but clear evidence of efficacy remains to be shown. Although evidence of efficacy for mono-treatment with vitamin D analogues is currently lacking, several studies have reported that supplementation with calcitriol or the presence of high endogenous circulating levels of vitamin D enhances response to standard therapies." @default.
• W2590130519 created "2017-03-03" @default.
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• W2590130519 date "2017-04-01" @default.
• W2590130519 modified "2023-09-24" @default.
• W2590130519 title "Vitamin D analogues: Potential use in cancer treatment" @default.
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• W2590130519 cites W1828689071 @default.
• W2590130519 cites W1852205543 @default.
• W2590130519 cites W1862297559 @default.
• W2590130519 cites W1941840880 @default.
• W2590130519 cites W1970890299 @default.
• W2590130519 cites W1971199114 @default.
• W2590130519 cites W1972960454 @default.
• W2590130519 cites W1975278455 @default.
• W2590130519 cites W1980154856 @default.
• W2590130519 cites W1982294311 @default.
• W2590130519 cites W1986240597 @default.
• W2590130519 cites W1987544482 @default.
• W2590130519 cites W1994151649 @default.
• W2590130519 cites W1996120018 @default.
• W2590130519 cites W1999861997 @default.
• W2590130519 cites W2011639195 @default.
• W2590130519 cites W2019962813 @default.
• W2590130519 cites W2020994990 @default.
• W2590130519 cites W2021501597 @default.
• W2590130519 cites W2021926444 @default.
• W2590130519 cites W2024069889 @default.
• W2590130519 cites W2031673370 @default.
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• W2590130519 cites W2073599728 @default.
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• W2590130519 doi "https://doi.org/10.1016/j.critrevonc.2017.02.015" @default.
• W2590130519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28325259" @default.
• W2590130519 hasPublicationYear "2017" @default.
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