FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2590141723> ?p ?o ?g. }

• W2590141723 endingPage "87" @default.
• W2590141723 startingPage "87" @default.
• W2590141723 abstract "87 Background: The adverse events of androgen deprivation therapy (ADT) are widely recognized, but ADT-induced alterations in lipid and glucose metabolism may be race-dependent. We prospectively recruited Japanese patients with newly diagnosed prostate cancer who underwent at least one year of ADT and examined changes in lipid and glucose metabolism in these patients. Methods: Patients with newly diagnosed prostate cancer were recruited between January 2011 and August 2012. Body weight, abdominal circumference, and blood testing results were recorded every three months, and visceral and subcutaneous fat were measured by computed tomography before and after one year of ADT. Results: One hundred three patients completed a one year course of ADT. Median age was 74 (range, 50 to 85). Thirty nine patients underwent ADT with luteinizing hormone-releasing hormone (LHRH) agonist monotherapy, while 64 patients underwent ADT with LH-RH agonist plus bicalutamide. Median prostate-specific antigen (PSA) before ADT was 16.7 ng/ml (range, 3.6-3316 ng/ml). Clinical stage was B (46.6%), C (28.2%), and D (25.2%). Mean increase in body weight, abdominal circumference and body mass index after one year of ADT was 3.8%, 4.1%, and 3.8%, respectively. Mean decrease of hemoglobin was 5.5%. Mean increase of total, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides was 9.0%, 10.8%, 5.0%, and 21.0%, respectively. Mean increase in fasting blood sugar and HbA1c was 4.6% and 1.7%, respectively. Changes in each variable from baseline to 0, 3, 6, 9, and 12 months was as follows: body weight, 0, 0.9, 2.7, 3.3, and 3.8%; hemoglobin, 0, 4.5, 3.7, 5.5, and 5.5%; total cholesterol, 0, 12.9, 11.4, 9.7, and 9.0%; triglycerides, 18, 26, 25, 21%; and HbA1c, 0, 2.1, 1.2, 1.2, and 1.7%. Increase of visceral and subcutaneous fat measured by computed tomography before and after one year of ADT was 32.4% and 35.4%, respectively. Conclusions: One year of ADT caused significant changes, especially in lipid metabolism, in Japanese patients with prostate cancer. Visceral and subcutaneous fat increased more than 30%. These changes were noticeable in the first half of the one year course of ADT. Appropriate monitoring and management of these patients is needed, because these changes might cause critical cardiovascular events. Clinical trial information: UMIN000004709." @default.
• W2590141723 created "2017-03-03" @default.
• W2590141723 creator A5009697572 @default.
• W2590141723 creator A5033476836 @default.
• W2590141723 creator A5047951647 @default.
• W2590141723 creator A5055415323 @default.
• W2590141723 creator A5057558965 @default.
• W2590141723 creator A5059250423 @default.
• W2590141723 creator A5060289225 @default.
• W2590141723 creator A5065926823 @default.
• W2590141723 creator A5080725230 @default.
• W2590141723 creator A5085041532 @default.
• W2590141723 date "2014-02-01" @default.
• W2590141723 modified "2023-09-26" @default.
• W2590141723 title "Influence of one-year androgen deprivation therapy on lipid and glucose metabolism in patients with newly diagnosed prostate cancer." @default.
• W2590141723 doi "https://doi.org/10.1200/jco.2014.32.4_suppl.87" @default.
• W2590141723 hasPublicationYear "2014" @default.
• W2590141723 type Work @default.
• W2590141723 sameAs 2590141723 @default.
• W2590141723 citedByCount "0" @default.
• W2590141723 crossrefType "journal-article" @default.
• W2590141723 hasAuthorship W2590141723A5009697572 @default.
• W2590141723 hasAuthorship W2590141723A5033476836 @default.
• W2590141723 hasAuthorship W2590141723A5047951647 @default.
• W2590141723 hasAuthorship W2590141723A5055415323 @default.
• W2590141723 hasAuthorship W2590141723A5057558965 @default.
• W2590141723 hasAuthorship W2590141723A5059250423 @default.
• W2590141723 hasAuthorship W2590141723A5060289225 @default.
• W2590141723 hasAuthorship W2590141723A5065926823 @default.
• W2590141723 hasAuthorship W2590141723A5080725230 @default.
• W2590141723 hasAuthorship W2590141723A5085041532 @default.
• W2590141723 hasConcept C121608353 @default.
• W2590141723 hasConcept C126322002 @default.
• W2590141723 hasConcept C126894567 @default.
• W2590141723 hasConcept C134018914 @default.
• W2590141723 hasConcept C2777899217 @default.
• W2590141723 hasConcept C2779279991 @default.
• W2590141723 hasConcept C2780192828 @default.
• W2590141723 hasConcept C2780221984 @default.
• W2590141723 hasConcept C71924100 @default.
• W2590141723 hasConcept C90924648 @default.
• W2590141723 hasConceptScore W2590141723C121608353 @default.
• W2590141723 hasConceptScore W2590141723C126322002 @default.
• W2590141723 hasConceptScore W2590141723C126894567 @default.
• W2590141723 hasConceptScore W2590141723C134018914 @default.
• W2590141723 hasConceptScore W2590141723C2777899217 @default.
• W2590141723 hasConceptScore W2590141723C2779279991 @default.
• W2590141723 hasConceptScore W2590141723C2780192828 @default.
• W2590141723 hasConceptScore W2590141723C2780221984 @default.
• W2590141723 hasConceptScore W2590141723C71924100 @default.
• W2590141723 hasConceptScore W2590141723C90924648 @default.
• W2590141723 hasIssue "4_suppl" @default.
• W2590141723 hasLocation W25901417231 @default.
• W2590141723 hasOpenAccess W2590141723 @default.
• W2590141723 hasPrimaryLocation W25901417231 @default.
• W2590141723 hasRelatedWork W1988486434 @default.
• W2590141723 hasRelatedWork W1998113603 @default.
• W2590141723 hasRelatedWork W1999611386 @default.
• W2590141723 hasRelatedWork W1999831221 @default.
• W2590141723 hasRelatedWork W2027237635 @default.
• W2590141723 hasRelatedWork W2036308844 @default.
• W2590141723 hasRelatedWork W2047880909 @default.
• W2590141723 hasRelatedWork W2087168955 @default.
• W2590141723 hasRelatedWork W2100202028 @default.
• W2590141723 hasRelatedWork W2909802736 @default.
• W2590141723 hasVolume "32" @default.
• W2590141723 isParatext "false" @default.
• W2590141723 isRetracted "false" @default.
• W2590141723 magId "2590141723" @default.
• W2590141723 workType "article" @default.