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- W2590211708 abstract "[ Summary ] Diabetic rat model was established by peritoneal injection of streptozocin. At the end of 2 weeks, oxidized low-density lipoprotein （oxLDL） level in diabetic rats was raised [ （2.87 ±0.40 vs 2.27± 0.36 ） μg/dl, P〈 0.05 ] and endothelium-dependent relaxation was sluggish compared with normal rats. At the end of 6 weeks, oxLDL level continued to increase [ 4.32± 0.66 ） μg/dl, P〈0.01 ] and endothelium-dependent maximum relaxation （ Rmax ） was decreased obviously （P〈 0. 01 ）. Meanwhile, the protein and mRNA expressions of lectin-like oxidized low- density lipoprotein receptor-1 （ LOX-1 ） , NF-κB, and ICAM-1 on vessel wall of diabetic rats were higher than those in normal rats, and LOX-1 mRNA was positively correlated with the levels of oxLDL, NF-κB, and ICAM-1 mRNA, while negatively correlated with Rmax, indicating that OxLDL/LOX-1 system may cause early endothelial dysfunction in diabetes via activating NF-κB and up-regulating ICAM-1 expression.Key words: Diabetes mellitus ; Oxidized low-density lipoprotein ; Lectin-like oxidized low-density lipoprotein receptor-1 ; Nuclear factor-κB ; Vascular endothelial dysfunction" @default.
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- W2590211708 date "2012-07-25" @default.
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- W2590211708 title "Role of oxLDL/LOX-1 system and NF-κB pathway in early diabetic vascular endothelial dysfunction" @default.
- W2590211708 doi "https://doi.org/10.3760/cma.j.issn.1000-6699.2012.07.017" @default.
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