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• W2590229308 abstract "Transdermal drug delivery offers a number of advantages due to its minimally invasive and painless approach as well as the avoidance of first-pass drug metabolism and gastrointestinal degradation. However, most of the transdermal drug delivery systems face the challenges of low drug permeability across the skin. The outermost layer stratum corneum and the entire epidermis pose a significant barrier. To overcome this problem researchers have developed microneedles as therapeutic vehicles to transport drugs across the different layers of skin. After many decades of research, scientists have developed microfabrication technologies to fabricate microneedles of different size and types depending on the type of drug to be administered, injection site, and depth of skin where drug needs to be injected. The early development of microneedle produced solid microneedle for skin pretreatment to enhance drug permeation. Drug-coated microneedles dissolve in the skin upon application, dissolving microneedles encapsulating drug fully dissolve in the skin producing no sharp waste, and hollow microneedles can help drug infusion into the skin. Finally, advancement led to the development of hydrogel-forming microneedles with reservoir, it allows drug diffusion through swollen microneedles. This type of microneedle has been developed with an idea to overcome the disadvantages of previously developed devices. Microneedles have been successfully introduced in preclinical and clinical studies to deliver a wide range of drug molecules, including vaccines, small and large molecules, and biotherapeutics such as proteins, peptides, and hormones. In this chapter we have discussed the current microneedle devices and drug delivery systems." @default.
• W2590229308 created "2017-03-03" @default.
• W2590229308 creator A5034056825 @default.
• W2590229308 date "2017-01-01" @default.
• W2590229308 modified "2023-09-23" @default.
• W2590229308 title "Microneedles in Drug Delivery" @default.
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• W2590229308 doi "https://doi.org/10.1016/b978-0-323-42978-8.00013-9" @default.
• W2590229308 hasPublicationYear "2017" @default.
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