FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2590281714> ?p ?o ?g. }

• W2590281714 endingPage "16.2017" @default.
• W2590281714 startingPage "ENEURO.0285" @default.
• W2590281714 abstract "New antidepressant pharmacotherapies that provide rapid relief of depressive symptoms are needed. The NMDA receptor antagonist ketamine exerts rapid antidepressant actions in depressed patients but also side effects that complicate its clinical utility. Ketamine promotes excitatory synaptic strength, likely by producing high-frequency correlated activity in mood-relevant regions of the forebrain. Negative allosteric modulators of GABA-A receptors containing α5 subunits (α5 GABA-NAMs) should also promote high-frequency correlated electroencephalogram (EEG) activity and should therefore exert rapid antidepressant responses. Because α5 subunits display a restricted expression in the forebrain, we predicted that α5 GABA-NAMs would produce activation of principle neurons but exert fewer side effects than ketamine. We tested this hypothesis in male mice and observed that the α5 GABA-NAM MRK-016 exerted an antidepressant-like response in the forced swim test at 1 and 24 h after administration and an anti-anhedonic response after chronic stress in the female urine sniffing test (FUST). Like ketamine, MRK-016 produced a transient increase in EEG γ power, and both the increase in γ power and its antidepressant effects in the forced swim test were blocked by prior administration of the AMPA-type glutamate receptor antagonist 2,3-dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide (NBQX). Unlike ketamine, however, MRK-016 produced no impairment of rota-rod performance, no reduction of prepulse inhibition (PPI), no conditioned-place preference (CPP), and no change in locomotion. α5 GABA-NAMs, thus reproduce the rapid antidepressant-like actions of ketamine, perhaps via an AMPA receptor (AMPAR)-dependent increase in coherent neuronal activity, but display fewer potential negative side effects. These compounds thus demonstrate promise as clinically useful fast-acting antidepressants." @default.
• W2590281714 created "2017-03-03" @default.
• W2590281714 creator A5028162083 @default.
• W2590281714 creator A5037853531 @default.
• W2590281714 creator A5043556762 @default.
• W2590281714 creator A5072690915 @default.
• W2590281714 creator A5076395304 @default.
• W2590281714 creator A5078032075 @default.
• W2590281714 creator A5086067811 @default.
• W2590281714 date "2017-01-01" @default.
• W2590281714 modified "2023-10-10" @default.
• W2590281714 title "A Negative Allosteric Modulator for α5 Subunit-Containing GABA Receptors Exerts a Rapid and Persistent Antidepressant-Like Action without the Side Effects of the NMDA Receptor Antagonist Ketamine in Mice" @default.
• W2590281714 cites W1603938906 @default.
• W2590281714 cites W1948877773 @default.
• W2590281714 cites W1961364466 @default.
• W2590281714 cites W1970448316 @default.
• W2590281714 cites W1978891587 @default.
• W2590281714 cites W1981032504 @default.
• W2590281714 cites W1981097208 @default.
• W2590281714 cites W1982860158 @default.
• W2590281714 cites W1987239750 @default.
• W2590281714 cites W1989321110 @default.
• W2590281714 cites W2002843427 @default.
• W2590281714 cites W2003982930 @default.
• W2590281714 cites W2013775967 @default.
• W2590281714 cites W2022082745 @default.
• W2590281714 cites W2023081218 @default.
• W2590281714 cites W2024465340 @default.
• W2590281714 cites W2029056592 @default.
• W2590281714 cites W2032739515 @default.
• W2590281714 cites W2035310051 @default.
• W2590281714 cites W2047276596 @default.
• W2590281714 cites W2052830386 @default.
• W2590281714 cites W2056406527 @default.
• W2590281714 cites W2065507003 @default.
• W2590281714 cites W2067071072 @default.
• W2590281714 cites W2068282468 @default.
• W2590281714 cites W2070005343 @default.
• W2590281714 cites W2072336593 @default.
• W2590281714 cites W2082443814 @default.
• W2590281714 cites W2086079205 @default.
• W2590281714 cites W2087002084 @default.
• W2590281714 cites W2088861514 @default.
• W2590281714 cites W2089351762 @default.
• W2590281714 cites W2095043290 @default.
• W2590281714 cites W2095852687 @default.
• W2590281714 cites W2109334244 @default.
• W2590281714 cites W2117090183 @default.
• W2590281714 cites W2125314941 @default.
• W2590281714 cites W2126208320 @default.
• W2590281714 cites W2127070061 @default.
• W2590281714 cites W2132324173 @default.
• W2590281714 cites W2176587016 @default.
• W2590281714 cites W2346390990 @default.
• W2590281714 cites W2373469551 @default.
• W2590281714 cites W2533905828 @default.
• W2590281714 doi "https://doi.org/10.1523/eneuro.0285-16.2017" @default.
• W2590281714 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5334634" @default.
• W2590281714 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28275719" @default.
• W2590281714 hasPublicationYear "2017" @default.
• W2590281714 type Work @default.
• W2590281714 sameAs 2590281714 @default.
• W2590281714 citedByCount "86" @default.
• W2590281714 countsByYear W25902817142017 @default.
• W2590281714 countsByYear W25902817142018 @default.
• W2590281714 countsByYear W25902817142019 @default.
• W2590281714 countsByYear W25902817142020 @default.
• W2590281714 countsByYear W25902817142021 @default.
• W2590281714 countsByYear W25902817142022 @default.
• W2590281714 countsByYear W25902817142023 @default.
• W2590281714 crossrefType "journal-article" @default.
• W2590281714 hasAuthorship W2590281714A5028162083 @default.
• W2590281714 hasAuthorship W2590281714A5037853531 @default.
• W2590281714 hasAuthorship W2590281714A5043556762 @default.
• W2590281714 hasAuthorship W2590281714A5072690915 @default.
• W2590281714 hasAuthorship W2590281714A5076395304 @default.
• W2590281714 hasAuthorship W2590281714A5078032075 @default.
• W2590281714 hasAuthorship W2590281714A5086067811 @default.
• W2590281714 hasBestOaLocation W25902817141 @default.
• W2590281714 hasConcept C126322002 @default.
• W2590281714 hasConcept C136569192 @default.
• W2590281714 hasConcept C15744967 @default.
• W2590281714 hasConcept C160268369 @default.
• W2590281714 hasConcept C169760540 @default.
• W2590281714 hasConcept C170493617 @default.
• W2590281714 hasConcept C185592680 @default.
• W2590281714 hasConcept C2779177272 @default.
• W2590281714 hasConcept C2779715522 @default.
• W2590281714 hasConcept C2780076171 @default.
• W2590281714 hasConcept C2780795376 @default.
• W2590281714 hasConcept C2781161787 @default.
• W2590281714 hasConcept C529278444 @default.
• W2590281714 hasConcept C67018056 @default.
• W2590281714 hasConcept C71924100 @default.
• W2590281714 hasConcept C98274493 @default.
• W2590281714 hasConceptScore W2590281714C126322002 @default.
• W2590281714 hasConceptScore W2590281714C136569192 @default.
• W2590281714 hasConceptScore W2590281714C15744967 @default.

• next