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- W2590286111 abstract "2074 Background: Epilepsy may be the unique symptom in patients with slowly growing gliomas, is often pharmakoresistant, and negatively impacts the quality of life. Total surgical resection and, recently, chemotherapy have been reported to allow the control of seizures, whereas the role of radiation therapy is unclear. The aim of this study was to investigate the efficacy of radiotherapy in controlling the epileptic seizures in slowly growing gliomas. Methods: We retrospectively analyzed, utilizing the neuro-oncological database of the University Hospital of Turin, 40 patients with hemispheric grade 2 and 3 gliomas ( according to WHO classification), either newly diagnosed or recurrent, who had an active epilepsy before receiving radiation therapy between 1989 and 2009. Seizure decrease following radiotherapy was considered as significant when >= 50% reduction in seizure frequency from baseline was observed, being steroids stable and concomitant antiepileptic drugs unchanged or reduced. Response on MRI was evaluated based on changes of the tumor area in T2 – FLAIR sequences. Results: Overall, seizure frequency was significantly decreased in 24/40 (60%) and 29/40 (72.5%) patients at 1 and 3 months following radiotherapy respectively. In most patients seizure reduction began during radiation therapy. Eleven out of 40 patients (27.5%) began seizure-free. We did not find any correlation between seizure response and response of tumor on MRI: at 3 months following the radiotherapy, among patients with a significant seizure reduction, half had a partial response (>= 50% decrease on MRI) and half no change. Factors, such as histological type, grade of malignancy, tumor location, contrast enhancement on MRI and type of original surgery, did not influence the seizure response to radiotherapy. Conclusions: Epileptic seizures of patients with grade 2 and 3 gliomas can benefit from radiation therapy. Future studies must better clarify factors associated with this efficacy and the underlying mechanisms. Epilepsy control must be a secondary end-point in clinical trials involving grade 2 and 3 gliomas." @default.
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- W2590286111 date "2011-05-20" @default.
- W2590286111 modified "2023-10-14" @default.
- W2590286111 title "Efficacy of radiation therapy on epileptic seizures of grade 2 and 3 gliomas: A retrospective study." @default.
- W2590286111 doi "https://doi.org/10.1200/jco.2011.29.15_suppl.2074" @default.
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