Matches in SemOpenAlex for { <https://semopenalex.org/work/W2590336585> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2590336585 endingPage "255" @default.
- W2590336585 startingPage "255" @default.
- W2590336585 abstract "255 Background: Gleason score grading is a cornerstone of risk stratification and management of patients with prostate cancer (PCa). The only reliable method to determine Gleason score remains by direct pathologic determination from a tissue specimen. In this work, we examine the feasibility of MRI and clinical patient characteristics to predict biopsy Gleason scores (bGS). Methods: We reviewed 143 men who underwent multiparametric prostate-MRI (MP-MRI) prior to any prostate biopsy from 8/2007 to 12/2012. Patient demographics, PSA, PSA density (PSAD), and imaging findings were assessed for association with PCa Gleason score on biopsy. Screen positive lesions (SPLs) were defined as lesions positive on T2W and DWI B-MRI images. Logistic regression modeling was used to assess association of the different parameters with bGS (no cancer, Gleason 6, 7, and ≥8). An optimized model for the prediction of bGS was determined and a nomogram was generated. Results: The mean age of the cohort was 60.7 ± 7.7 years and mean PSA of 6.8 ± 6.5 ng/ml. Factors associated with Gleason score include age, PSA, PSAD, prostate volume, MRI suspicion score, total lesions seen on MRI, number of SPLs. Various models were examined utilizing factors positively associated with Gleason score and the combination of PSA density with SPLs outperformed most other combinations. A nomogram was generated to derive the probability of No cancer, Gleason 6, 7, and ≥8 PCa using the inputs of PSAD and number of SPLs. The correlating c-indexes to Gleason 6, 7, and ≥8 PCa detection were 0.87, 0.87, and 0.92 respectively. When tested on the original cohort, the most probable nomogram generated Gleason score correlates with actual pathologic bGS findings in 53% of the men. The top two most probable nomogram Gleason scores contained the actual bGS findings in 81% of the men. Conclusions: PSAD combined with prostate MRI imaging characteristics shows potential for prebiopsy determination of prostate cancer Gleason score and presence. Further improvement in predictive performance of this test may ultimately yield a clinical tool that is of benefit for prebiopsy risk stratification of patients for PCa of clinical significance." @default.
- W2590336585 created "2017-03-03" @default.
- W2590336585 creator A5022455023 @default.
- W2590336585 creator A5024598099 @default.
- W2590336585 creator A5025986648 @default.
- W2590336585 creator A5026470145 @default.
- W2590336585 creator A5031506572 @default.
- W2590336585 creator A5036618005 @default.
- W2590336585 creator A5038850729 @default.
- W2590336585 creator A5038941421 @default.
- W2590336585 creator A5046240395 @default.
- W2590336585 creator A5052820201 @default.
- W2590336585 creator A5053618839 @default.
- W2590336585 creator A5059189018 @default.
- W2590336585 creator A5065848215 @default.
- W2590336585 creator A5067425469 @default.
- W2590336585 creator A5082080836 @default.
- W2590336585 date "2014-02-01" @default.
- W2590336585 modified "2023-09-30" @default.
- W2590336585 title "Prediction of prostate cancer Gleason score using a MRI-based nomogram." @default.
- W2590336585 doi "https://doi.org/10.1200/jco.2014.32.4_suppl.255" @default.
- W2590336585 hasPublicationYear "2014" @default.
- W2590336585 type Work @default.
- W2590336585 sameAs 2590336585 @default.
- W2590336585 citedByCount "1" @default.
- W2590336585 countsByYear W25903365852019 @default.
- W2590336585 crossrefType "journal-article" @default.
- W2590336585 hasAuthorship W2590336585A5022455023 @default.
- W2590336585 hasAuthorship W2590336585A5024598099 @default.
- W2590336585 hasAuthorship W2590336585A5025986648 @default.
- W2590336585 hasAuthorship W2590336585A5026470145 @default.
- W2590336585 hasAuthorship W2590336585A5031506572 @default.
- W2590336585 hasAuthorship W2590336585A5036618005 @default.
- W2590336585 hasAuthorship W2590336585A5038850729 @default.
- W2590336585 hasAuthorship W2590336585A5038941421 @default.
- W2590336585 hasAuthorship W2590336585A5046240395 @default.
- W2590336585 hasAuthorship W2590336585A5052820201 @default.
- W2590336585 hasAuthorship W2590336585A5053618839 @default.
- W2590336585 hasAuthorship W2590336585A5059189018 @default.
- W2590336585 hasAuthorship W2590336585A5065848215 @default.
- W2590336585 hasAuthorship W2590336585A5067425469 @default.
- W2590336585 hasAuthorship W2590336585A5082080836 @default.
- W2590336585 hasConcept C121608353 @default.
- W2590336585 hasConcept C126322002 @default.
- W2590336585 hasConcept C126838900 @default.
- W2590336585 hasConcept C126894567 @default.
- W2590336585 hasConcept C127413603 @default.
- W2590336585 hasConcept C143998085 @default.
- W2590336585 hasConcept C147176958 @default.
- W2590336585 hasConcept C151956035 @default.
- W2590336585 hasConcept C2775934546 @default.
- W2590336585 hasConcept C2776235491 @default.
- W2590336585 hasConcept C2777286243 @default.
- W2590336585 hasConcept C2779466945 @default.
- W2590336585 hasConcept C2780192828 @default.
- W2590336585 hasConcept C34626388 @default.
- W2590336585 hasConcept C71924100 @default.
- W2590336585 hasConcept C72563966 @default.
- W2590336585 hasConceptScore W2590336585C121608353 @default.
- W2590336585 hasConceptScore W2590336585C126322002 @default.
- W2590336585 hasConceptScore W2590336585C126838900 @default.
- W2590336585 hasConceptScore W2590336585C126894567 @default.
- W2590336585 hasConceptScore W2590336585C127413603 @default.
- W2590336585 hasConceptScore W2590336585C143998085 @default.
- W2590336585 hasConceptScore W2590336585C147176958 @default.
- W2590336585 hasConceptScore W2590336585C151956035 @default.
- W2590336585 hasConceptScore W2590336585C2775934546 @default.
- W2590336585 hasConceptScore W2590336585C2776235491 @default.
- W2590336585 hasConceptScore W2590336585C2777286243 @default.
- W2590336585 hasConceptScore W2590336585C2779466945 @default.
- W2590336585 hasConceptScore W2590336585C2780192828 @default.
- W2590336585 hasConceptScore W2590336585C34626388 @default.
- W2590336585 hasConceptScore W2590336585C71924100 @default.
- W2590336585 hasConceptScore W2590336585C72563966 @default.
- W2590336585 hasIssue "4_suppl" @default.
- W2590336585 hasLocation W25903365851 @default.
- W2590336585 hasOpenAccess W2590336585 @default.
- W2590336585 hasPrimaryLocation W25903365851 @default.
- W2590336585 hasRelatedWork W108895284 @default.
- W2590336585 hasRelatedWork W1530684645 @default.
- W2590336585 hasRelatedWork W1979374145 @default.
- W2590336585 hasRelatedWork W2049649233 @default.
- W2590336585 hasRelatedWork W2102167265 @default.
- W2590336585 hasRelatedWork W2148869351 @default.
- W2590336585 hasRelatedWork W2151006016 @default.
- W2590336585 hasRelatedWork W2172257731 @default.
- W2590336585 hasRelatedWork W2587028338 @default.
- W2590336585 hasRelatedWork W2973010805 @default.
- W2590336585 hasVolume "32" @default.
- W2590336585 isParatext "false" @default.
- W2590336585 isRetracted "false" @default.
- W2590336585 magId "2590336585" @default.
- W2590336585 workType "article" @default.