Matches in SemOpenAlex for { <https://semopenalex.org/work/W2590348524> ?p ?o ?g. }
- W2590348524 endingPage "66" @default.
- W2590348524 startingPage "59" @default.
- W2590348524 abstract "Sinoporphyrin sodium (DVDMS) is a novel photosensitizer with high photodynamic therapy (PDT) effect. Reasons for its high photo-activity were investigated according to the study of photophysical characteristics of DVDMS. Extinction coefficients ([Formula: see text] of DVDMS at 405 nm and 630 nm are 4.36 × 10 5 and 1.84 × 10 4 M[Formula: see text].cm[Formula: see text]; fluorescence quantum yield ([Formula: see text] is 0.026; quantum yield of lowest triplet state formation is 0.94 and singlet oxygen quantum yield ([Formula: see text] is 0.92. Although [Formula: see text] of DVDMS is only 10% higher than that of Photofrin[Formula: see text] (0.83), the extinction coefficient of DVDMS at 630 nm is 10-fold greater than that of Photofrin[Formula: see text]. This leads to its higher singlet oxygen generation efficiency ([Formula: see text]. The higher [Formula: see text] of DVDMS can result in an effective reduction of dosage (1/10 of Photofrin[Formula: see text] reaching the same cytotoxic effect as Photofrin[Formula: see text]. Even though [Formula: see text] is approximately equal to that of Photofrin[Formula: see text], brightness ([Formula: see text] of DVDMS is 10-fold greater than that of Photofrin[Formula: see text] because of the 10-fold greater extinction coefficient. Thus, fluorescence diagnosis ability of 0.2 mg/kg DVDMS is comparable to that of 2 mg/kg Photofrin[Formula: see text] used in PDT. Overall, the 10-fold greater extinction coefficients are responsible for the high brightness and singlet oxygen generation efficiency of DVDMS." @default.
- W2590348524 created "2017-03-03" @default.
- W2590348524 creator A5009033819 @default.
- W2590348524 creator A5018103708 @default.
- W2590348524 creator A5018294362 @default.
- W2590348524 creator A5018882443 @default.
- W2590348524 creator A5021362384 @default.
- W2590348524 creator A5037342605 @default.
- W2590348524 creator A5037816329 @default.
- W2590348524 creator A5044396095 @default.
- W2590348524 creator A5056860845 @default.
- W2590348524 creator A5090650583 @default.
- W2590348524 date "2017-01-01" @default.
- W2590348524 modified "2023-09-25" @default.
- W2590348524 title "Photophysical properties of sinoporphyrin sodium and explanation of its high photo-activity" @default.
- W2590348524 cites W1536155243 @default.
- W2590348524 cites W1546940887 @default.
- W2590348524 cites W1759964073 @default.
- W2590348524 cites W1969571726 @default.
- W2590348524 cites W1972553524 @default.
- W2590348524 cites W1975458326 @default.
- W2590348524 cites W1975823196 @default.
- W2590348524 cites W1985425964 @default.
- W2590348524 cites W1987162406 @default.
- W2590348524 cites W1988736913 @default.
- W2590348524 cites W1988765421 @default.
- W2590348524 cites W1988847743 @default.
- W2590348524 cites W1994318583 @default.
- W2590348524 cites W1997337296 @default.
- W2590348524 cites W1999039357 @default.
- W2590348524 cites W2019825048 @default.
- W2590348524 cites W2030803133 @default.
- W2590348524 cites W2041205350 @default.
- W2590348524 cites W2044533112 @default.
- W2590348524 cites W2070336100 @default.
- W2590348524 cites W2075277457 @default.
- W2590348524 cites W2076285867 @default.
- W2590348524 cites W2077978472 @default.
- W2590348524 cites W2078243646 @default.
- W2590348524 cites W2079046809 @default.
- W2590348524 cites W2084045453 @default.
- W2590348524 cites W2086736869 @default.
- W2590348524 cites W2087426457 @default.
- W2590348524 cites W2088487264 @default.
- W2590348524 cites W2088829388 @default.
- W2590348524 cites W2091210609 @default.
- W2590348524 cites W2099132116 @default.
- W2590348524 cites W2103035005 @default.
- W2590348524 cites W2109212145 @default.
- W2590348524 cites W2110738019 @default.
- W2590348524 cites W2141519994 @default.
- W2590348524 cites W2156975699 @default.
- W2590348524 cites W2157812356 @default.
- W2590348524 cites W2161039998 @default.
- W2590348524 cites W2323780697 @default.
- W2590348524 cites W4211024586 @default.
- W2590348524 doi "https://doi.org/10.1142/s1088424617500055" @default.
- W2590348524 hasPublicationYear "2017" @default.
- W2590348524 type Work @default.
- W2590348524 sameAs 2590348524 @default.
- W2590348524 citedByCount "11" @default.
- W2590348524 countsByYear W25903485242017 @default.
- W2590348524 countsByYear W25903485242018 @default.
- W2590348524 countsByYear W25903485242019 @default.
- W2590348524 countsByYear W25903485242020 @default.
- W2590348524 countsByYear W25903485242022 @default.
- W2590348524 crossrefType "journal-article" @default.
- W2590348524 hasAuthorship W2590348524A5009033819 @default.
- W2590348524 hasAuthorship W2590348524A5018103708 @default.
- W2590348524 hasAuthorship W2590348524A5018294362 @default.
- W2590348524 hasAuthorship W2590348524A5018882443 @default.
- W2590348524 hasAuthorship W2590348524A5021362384 @default.
- W2590348524 hasAuthorship W2590348524A5037342605 @default.
- W2590348524 hasAuthorship W2590348524A5037816329 @default.
- W2590348524 hasAuthorship W2590348524A5044396095 @default.
- W2590348524 hasAuthorship W2590348524A5056860845 @default.
- W2590348524 hasAuthorship W2590348524A5090650583 @default.
- W2590348524 hasConcept C101991246 @default.
- W2590348524 hasConcept C113196181 @default.
- W2590348524 hasConcept C120665830 @default.
- W2590348524 hasConcept C121332964 @default.
- W2590348524 hasConcept C125245961 @default.
- W2590348524 hasConcept C171001562 @default.
- W2590348524 hasConcept C178790620 @default.
- W2590348524 hasConcept C181500209 @default.
- W2590348524 hasConcept C185592680 @default.
- W2590348524 hasConcept C199289684 @default.
- W2590348524 hasConcept C2777516457 @default.
- W2590348524 hasConcept C2781323092 @default.
- W2590348524 hasConcept C2781469039 @default.
- W2590348524 hasConcept C33062035 @default.
- W2590348524 hasConcept C540031477 @default.
- W2590348524 hasConcept C62520636 @default.
- W2590348524 hasConcept C75473681 @default.
- W2590348524 hasConcept C76046532 @default.
- W2590348524 hasConcept C91881484 @default.
- W2590348524 hasConceptScore W2590348524C101991246 @default.
- W2590348524 hasConceptScore W2590348524C113196181 @default.