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- W2590348577 abstract "Both zinc and the α-subunit of hypoxia-inducible factor (HIF-1α) play important roles in the remodelling of mammary gland tissues. In the present study, we examined the level and the transcriptional activity of HIF-1α in mammary cells upon zinc treatment. In MCF-7 mammary adenocarcinoma and MCF-10A mammary epithelial cell lines, the toxicity levels of zinc differ. Interestingly, both cell lines overexpress HIF-1α following zinc treatment. As it was evident from an up-regulation of its specific target gene CA9 that encodes carbonic anhydrase IX, the stabilized HIF-1α translocated to the nucleus and was transcriptionally active. Hence, we conclude that zinc causes normoxic accumulation of transcriptionally active HIF-1α by interfering with its post-translational regulation." @default.
- W2590348577 created "2017-03-03" @default.
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- W2590348577 date "2017-01-01" @default.
- W2590348577 modified "2023-10-16" @default.
- W2590348577 title "ЦИНК ИНДУЦИРУЕТ АККУМУЛЯЦИЮ ТРАНСКРИПЦИОННО АКТИВНОГО ИНДУЦИРУЕМОГО ГИПОКСИЕЙ ФАКТОРА 1-АЛЬФА В ЭПИТЕЛИАЛЬНЫХ КЛЕТКАХ МОЛОЧНОЙ ЖЕЛЕЗЫ В УСЛОВИЯХ НОРМОКСИИ#, Молекулярная биология" @default.
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- W2590348577 doi "https://doi.org/10.7868/s0026898417010116" @default.
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