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- W2590353640 abstract "Ophthalmic diagnostic imaging using optical coherence tomography (OCT) is limited by bulk eye motions and afundamental trade-off between field-of-view (FOV) and sampling density. Here, we introduced a novel multi-volumetricregistration and mosaicking method using our previously described multimodal swept-source spectrally encoded scanninglaser ophthalmoscopy and OCT (SS-SESLO-OCT) system. Our SS-SESLO-OCT acquires an entire en face fundus SESLOimage simultaneously with every OCT cross-section at 200 frames-per-second. In vivo human retinal imaging wasperformed in a healthy volunteer, and three volumetric datasets were acquired with the volunteer moving freely and refixatingbetween each acquisition. In post-processing, SESLO frames were used to estimate en face rotational andtranslational motions by registering every frame in all three volumetric datasets to the first frame in the first volume. OCTcross-sections were contrast-normalized and registered axially and rotationally across all volumes. Rotational andtranslational motions calculated from SESLO frames were applied to corresponding OCT B-scans to compensate for interandintra-B-scan bulk motions, and the three registered volumes were combined into a single interpolated multi-volumetricmosaic. Using complementary information from SESLO and OCT over serially acquired volumes, we demonstrated multivolumetricregistration and mosaicking to recover regions of missing data resulting from blinks, saccades, and oculardrifts. We believe our registration method can be directly applied for multi-volumetric motion compensation, averaging,widefield mosaicking, and vascular mapping with potential applications in ophthalmic clinical diagnostics, handheldimaging, and intraoperative guidance." @default.
- W2590353640 created "2017-03-03" @default.
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- W2590353640 date "2017-02-17" @default.
- W2590353640 modified "2023-09-27" @default.
- W2590353640 title "Multi-volumetric registration and mosaicking using swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography" @default.
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- W2590353640 doi "https://doi.org/10.1117/12.2254859" @default.
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