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- W2590359980 abstract "16599 Background: Breast cancer often metastasizes to the ovary. Pathological differential diagnosis between primary ovarian carcinoma and breast cancer metastases may be difficult. We developed a molecular tool to discriminate between these diagnoses. Methods: The pangenomic profiles of 13 pairs of primary breast carcinoma and ovary tumors (primary tumors or breast metastases) from the same patients were analyzed using the Affymetrix GeneChip Mapping 50K (XbaI) SNP arrays. The data were normalized with ITALICS algorithm (Rigaill et al., Bioinformatics, 2008). A partial identity score developed using DNA breakpoint information was used to quantify partial identity between two tumors (Bollet et al., JNCI, 2008). The nature of ovary tumors (primary tumor or breast metastasis) as defined using the partial identity score was compared with that based on pathological characteristics. Results: For ten pairs, the pathological diagnosis agreed with the result of the partial identity score. For the three remaining pairs, the discordance could be explained by the fact that genomics profiles of the breast tumors were little altered. The low number of breakpoints in these tumors induces a score less robust than in tumors with profound genomic alterations. Conclusions: These preliminary results show the potential of such a genome wide molecular based approach to solve difficult diagnostic issues. Further studies will improve the robustness of this score and confirm its usefulness. No significant financial relationships to disclose." @default.
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- W2590359980 date "2008-05-20" @default.
- W2590359980 modified "2023-10-17" @default.
- W2590359980 title "A molecular tool to distinguish breast carcinoma metastases to the ovary and primary ovarian carcinomas" @default.
- W2590359980 doi "https://doi.org/10.1200/jco.2008.26.15_suppl.16599" @default.
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