Matches in SemOpenAlex for { <https://semopenalex.org/work/W2590394007> ?p ?o ?g. }
- W2590394007 endingPage "935" @default.
- W2590394007 startingPage "917" @default.
- W2590394007 abstract "In this review, we discuss the role of nitric oxide (NO) as a key physiological mechanotransducer modulating both local and systemic heterocellular communication and contributing to the integrated (patho)physiology of the cardiovascular system. A deeper understanding of mechanotransduction-mediated local and systemic nodes controlling heterocellular communication between the endothelium, blood cells, and other cell types (e.g., cardiomyocytes) may suggest novel therapeutic strategies for endothelial dysfunction and cardiovascular disease. Recent Advances: Mechanical forces acting on mechanoreceptors on endothelial cells activate the endothelial NO synthase (eNOS) to produce NO. NO participates in (i) abluminal heterocellular communication, inducing vasorelaxation, and thereby regulating vascular tone and blood pressure; (ii) luminal heterocellular communication, inhibiting platelet aggregation, and controlling hemostasis; and (iii) systemic heterocellular communication, contributing to adaptive physiological processes in response to exercise and remote ischemic preconditioning. Interestingly, shear-induced eNOS-dependent activation of vascular heterocellular communication constitutes the molecular basis of all methods applied in the clinical routine for evaluation of endothelial function. Critical Issues and Future Directions: The integrated physiology of heterocellular communication is still not fully understood. Dedicated experimental models are needed to analyze messengers and mechanisms underpinning heterocellular communication in response to physical forces in the cardiovascular system (and elsewhere). Antioxid. Redox Signal. 26, 917-935." @default.
- W2590394007 created "2017-03-03" @default.
- W2590394007 creator A5014397952 @default.
- W2590394007 creator A5062165317 @default.
- W2590394007 creator A5063474266 @default.
- W2590394007 creator A5064701172 @default.
- W2590394007 creator A5067430418 @default.
- W2590394007 creator A5067753312 @default.
- W2590394007 date "2017-06-01" @default.
- W2590394007 modified "2023-10-14" @default.
- W2590394007 title "Modulation of Local and Systemic Heterocellular Communication by Mechanical Forces: A Role of Endothelial Nitric Oxide Synthase" @default.
- W2590394007 cites W1001378982 @default.
- W2590394007 cites W111626650 @default.
- W2590394007 cites W1521256352 @default.
- W2590394007 cites W1580536946 @default.
- W2590394007 cites W1603207692 @default.
- W2590394007 cites W1607892649 @default.
- W2590394007 cites W1684606992 @default.
- W2590394007 cites W1834747511 @default.
- W2590394007 cites W1929009802 @default.
- W2590394007 cites W1929519207 @default.
- W2590394007 cites W1936770188 @default.
- W2590394007 cites W1963782920 @default.
- W2590394007 cites W1964257347 @default.
- W2590394007 cites W1966814200 @default.
- W2590394007 cites W1967405452 @default.
- W2590394007 cites W196835504 @default.
- W2590394007 cites W1968569934 @default.
- W2590394007 cites W1971256361 @default.
- W2590394007 cites W1972771748 @default.
- W2590394007 cites W1974188641 @default.
- W2590394007 cites W1974640233 @default.
- W2590394007 cites W1981013677 @default.
- W2590394007 cites W1984776459 @default.
- W2590394007 cites W1988126593 @default.
- W2590394007 cites W1990126654 @default.
- W2590394007 cites W1993509160 @default.
- W2590394007 cites W1993695315 @default.
- W2590394007 cites W1996795941 @default.
- W2590394007 cites W1997692317 @default.
- W2590394007 cites W2000075945 @default.
- W2590394007 cites W2000165700 @default.
- W2590394007 cites W2003213503 @default.
- W2590394007 cites W2004175200 @default.
- W2590394007 cites W2004872903 @default.
- W2590394007 cites W2006256646 @default.
- W2590394007 cites W2008567062 @default.
- W2590394007 cites W2012574454 @default.
- W2590394007 cites W2016204376 @default.
- W2590394007 cites W2016913536 @default.
- W2590394007 cites W2017268417 @default.
- W2590394007 cites W2018344800 @default.
- W2590394007 cites W2019435702 @default.
- W2590394007 cites W2022473516 @default.
- W2590394007 cites W2022734495 @default.
- W2590394007 cites W2024131229 @default.
- W2590394007 cites W2030537932 @default.
- W2590394007 cites W2032715486 @default.
- W2590394007 cites W2033357754 @default.
- W2590394007 cites W2034407646 @default.
- W2590394007 cites W2034704466 @default.
- W2590394007 cites W2035508242 @default.
- W2590394007 cites W2035805518 @default.
- W2590394007 cites W2037390053 @default.
- W2590394007 cites W2038727826 @default.
- W2590394007 cites W2038965219 @default.
- W2590394007 cites W2039979152 @default.
- W2590394007 cites W2040148126 @default.
- W2590394007 cites W2044121023 @default.
- W2590394007 cites W2045096300 @default.
- W2590394007 cites W2045148129 @default.
- W2590394007 cites W2046155579 @default.
- W2590394007 cites W2048360028 @default.
- W2590394007 cites W2053492859 @default.
- W2590394007 cites W2053704719 @default.
- W2590394007 cites W2057919250 @default.
- W2590394007 cites W2058258523 @default.
- W2590394007 cites W2060100462 @default.
- W2590394007 cites W2062230565 @default.
- W2590394007 cites W2062394311 @default.
- W2590394007 cites W2063092400 @default.
- W2590394007 cites W2063220960 @default.
- W2590394007 cites W2067838633 @default.
- W2590394007 cites W2068395093 @default.
- W2590394007 cites W2068642993 @default.
- W2590394007 cites W2070845549 @default.
- W2590394007 cites W2071145526 @default.
- W2590394007 cites W2076612110 @default.
- W2590394007 cites W2076937557 @default.
- W2590394007 cites W2079129933 @default.
- W2590394007 cites W2080423485 @default.
- W2590394007 cites W2084121242 @default.
- W2590394007 cites W2084519533 @default.
- W2590394007 cites W2086105785 @default.
- W2590394007 cites W2086207695 @default.
- W2590394007 cites W2086552655 @default.
- W2590394007 cites W2090321557 @default.
- W2590394007 cites W2091765673 @default.