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- W2590426921 endingPage "e0172683" @default.
- W2590426921 startingPage "e0172683" @default.
- W2590426921 abstract "Na+ channel blockers flecainide and quinidine can increase propensity to ventricular tachyarrhythmia, whereas lidocaine and mexiletine are recognized as safe antiarrhythmics. Clinically, ventricular fibrillation is often precipitated by transient tachycardia that reduces action potential duration, suggesting that a critical shortening of the excitation wavelength (EW) may contribute to the arrhythmic substrate. This study examined whether different INa blockers can produce contrasting effects on the rate adaptation of the EW, which would explain the difference in their safety profile. In perfused guinea-pig hearts, effective refractory periods (ERP), conduction times, and EW values were determined over a wide range of cardiac pacing intervals. All INa blockers tested were found to flatten the slope of ERP restitution, indicating antiarrhythmic tendency. However, with flecainide and quinidine, the beneficial changes in ERP were reversed owing to the use-dependent conduction slowing, thereby leading to significantly steepened restitution of the EW. In contrast, lidocaine and mexiletine had no effect on ventricular conduction, and therefore reduced the slope of the EW restitution, as expected from their effect on ERP. These findings suggest that the slope of the EW restitution is an important electrophysiological determinant which can discriminate INa blockers with proarrhythmic and antiarrhythmic profile." @default.
- W2590426921 created "2017-03-03" @default.
- W2590426921 creator A5082800977 @default.
- W2590426921 date "2017-02-23" @default.
- W2590426921 modified "2023-10-18" @default.
- W2590426921 title "Effects of Na+ channel blockers on the restitution of refractory period, conduction time, and excitation wavelength in perfused guinea-pig heart" @default.
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- W2590426921 cites W1818765915 @default.
- W2590426921 cites W1841210729 @default.
- W2590426921 cites W1931655495 @default.
- W2590426921 cites W1964136288 @default.
- W2590426921 cites W1968612372 @default.
- W2590426921 cites W1969524515 @default.
- W2590426921 cites W1973480228 @default.
- W2590426921 cites W1974387201 @default.
- W2590426921 cites W1978565574 @default.
- W2590426921 cites W1978834734 @default.
- W2590426921 cites W1979703010 @default.
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- W2590426921 cites W1998000385 @default.
- W2590426921 cites W2004180639 @default.
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- W2590426921 doi "https://doi.org/10.1371/journal.pone.0172683" @default.
- W2590426921 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5322976" @default.
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