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- W2590479673 abstract "Formyl peptide receptor 1 (FPR1) is an emerging therapeutic target for the discovery of drugs to treat neutrophilic inflammatory diseases. However, development of FPR1 antagonists for clinical use is still inadequate. The purpose of this study was to identify a synthetic dipeptide N-(N-benzoyl-L-tryptophanyl)-D-phenylanlanine methyl ester (HCH6-1) as a FPR1 inhibitor and to investigate its protective effects against acute lung injury (ALI). HCH6-1 inhibited superoxide anion generation, elastase release, and chemotaxis in human neutrophils specifically activated by formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLF), an FPR1 agonist. HCH6-1 produced right shifts in the concentration-response curves of fMLF, suggesting that HCH6-1 was a competitive antagonist of FPR1. Indeed, HCH6-1 bound to FPR1 in human neutrophils and neutrophil-like THP-1 as well as hFPR1-transfected HEK293 cells. Also, the FPR1 downstream signaling pathways were competitively inhibited by HCH6-1. Furthermore, HCH6-1 prevented pulmonary neutrophil infiltration and edema along with alveolar damage in LPS-induced ALI in mice. Our findings suggest that HCH6-1, a FPR1 antagonist, may have potential as a new therapeutic agent for treating FPR1-involved inflammatory lung diseases." @default.
- W2590479673 created "2017-03-03" @default.
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- W2590479673 date "2017-05-01" @default.
- W2590479673 modified "2023-10-14" @default.
- W2590479673 title "Dipeptide HCH6-1 inhibits neutrophil activation and protects against acute lung injury by blocking FPR1" @default.
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- W2590479673 cites W1836133903 @default.
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- W2590479673 cites W1948427568 @default.
- W2590479673 cites W1967700327 @default.
- W2590479673 cites W1968326689 @default.
- W2590479673 cites W1968851649 @default.
- W2590479673 cites W1969981758 @default.
- W2590479673 cites W1973775002 @default.
- W2590479673 cites W1978740584 @default.
- W2590479673 cites W1981188731 @default.
- W2590479673 cites W1981645153 @default.
- W2590479673 cites W1982228337 @default.
- W2590479673 cites W1985629490 @default.
- W2590479673 cites W1987111128 @default.
- W2590479673 cites W1999213589 @default.
- W2590479673 cites W2001583365 @default.
- W2590479673 cites W2005018509 @default.
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- W2590479673 doi "https://doi.org/10.1016/j.freeradbiomed.2017.02.038" @default.
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