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- W2590499395 abstract "e13039 Background: Only 3-5% of new cancer pts participate in clinical trials, often resulting in prolonged trial completion timelines, and delays in the availability of effective treatment to pts. Barriers to pt accrual include physician awareness and attitudes, access to protocols, administrative burdens to conduct clinical trials, cost to physicians and pts, and pt concerns about participation in research trials. To overcome these barriers, DAVA Oncology has initiated strategies to improve clinical trial accrual that optimizes trial enrollment and engagement through a direct physician to physician intervention. Methods: Participating investigators are segmented into key performance categories that allow tactics to be tailored based upon the relative potential impact of each site to the trial. DAVA Medical Oncologists then engage with PIs using information such as customized enrollment plans that provide historical performance, site specific screening and enrollment challenges, and patient flow schematics. Key treatment specialists are targeted for trial education and engagement. Results: The implementation of direct physician-to-physician intervention resulted in a measurable improvement in the monthly accrual to each of 7 oncology trials. In two phase III studies, enrollment increased 16.3% per site/month during an 18 month engagement, and 27.7% during a 12 month engagement, respectively. Conclusions: The use of site specific strategies based upon performance potential, enrollment challenges and patient flow, tactically implemented by direct physician to physician contact, has been successful in significantly accelerating clinical trial accrual in 7 trials initiated to date. Accrual enhancement. Trial Accrual before* Accrual after* % Increase 1 0.11 0.14 27.7 2 0.23 0.27 16.3 * Patients per site per month." @default.
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- W2590499395 date "2011-05-20" @default.
- W2590499395 modified "2023-09-27" @default.
- W2590499395 title "Impact of direct physician-to-physician contact on accelerating oncology clinical trial accrual in multiple tumor types." @default.
- W2590499395 doi "https://doi.org/10.1200/jco.2011.29.15_suppl.e13039" @default.
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