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- W2590552215 abstract "The present work focused on neurophysiological and behavioral mechanisms related to healthy and pathological aging. The first study explored the behavioral and electrophysiological dynamics (N2pc and CDA) of multiple object processing in mild cognitive impairment and Alzheimer's disease (AD) patients to identify neurophysiological markers able to differentiate normal from pathological aging. Data suggested that CDA may be a useful neural signature to both distinguish between healthy and pathological aging and characterize the different stages along the AD continuum, possibly becoming a reliable candidate for an early diagnostic biomarker of AD pathology. The second study evaluated the possibility to apply a non-invasive neurorehabilitation protocol, by means of transcranial electrical stimulation (tES), to improve cognitive performance by increasing the level of arousal. Both the behavioral performance to a short term memory task and indexes of autonomic physiological activation (pupillary dilatation and skin conductance) were investigated in a group of healthy young subjects and in a group of healthy elderly subjects. In young, both behavioural and physiological responses were not modulated by tES application. In elderly, instead, real tES induced the report of a significant lower proportion of high salient stimuli, compared to the sham condition, suggesting a reduction of the memory span. The physiological indexes resulted unreliable in elderly participants and they could not be used to draw firm conclusions on the tES modulations of the level of arousal. These results showed that bursts of tES, applied during a short term memory task, differently modulated behavioural performance in young and elderly participants." @default.
- W2590552215 created "2017-03-03" @default.
- W2590552215 creator A5015093703 @default.
- W2590552215 date "2017-02-14" @default.
- W2590552215 modified "2023-09-23" @default.
- W2590552215 title "A MULTIMODAL APPROACH TO THE STUDY OF HEALTHY AND PATHOLOGICAL AGING" @default.
- W2590552215 hasPublicationYear "2017" @default.
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