Matches in SemOpenAlex for { <https://semopenalex.org/work/W2590568180> ?p ?o ?g. }
- W2590568180 endingPage "138" @default.
- W2590568180 startingPage "127" @default.
- W2590568180 abstract "The portal vertex in dsDNA bacteriophage serves as the site for genome encapsidation and release. In several of these viruses, efficient termination of DNA packaging has been shown to be dependent on the density of packaged DNA. The portal protein has been implicated as being part of the sensor that regulates packaging termination through DNA-dependent conformational changes during packaging. The mechanism by which DNA induces these conformational changes remains unknown. In this study, we explore how point mutants in the portal core can result in changes in genome packaging density in P22. Mutations in the portal core that subtly alter the structure or dynamics of the protein result in an increase in the amount of DNA packaged. The magnitude of the change is amino acid and location specific. Our findings suggest a mechanism wherein compression of the portal core is an essential aspect of signal transmission during packaging." @default.
- W2590568180 created "2017-03-03" @default.
- W2590568180 creator A5032778910 @default.
- W2590568180 creator A5066254776 @default.
- W2590568180 date "2017-05-01" @default.
- W2590568180 modified "2023-09-25" @default.
- W2590568180 title "Targeted mutagenesis of the P22 portal protein reveals the mechanism of signal transmission during DNA packaging" @default.
- W2590568180 cites W1574296936 @default.
- W2590568180 cites W1632730578 @default.
- W2590568180 cites W1963803709 @default.
- W2590568180 cites W1966346924 @default.
- W2590568180 cites W1981554446 @default.
- W2590568180 cites W1982917857 @default.
- W2590568180 cites W1985883507 @default.
- W2590568180 cites W1996373816 @default.
- W2590568180 cites W2007217395 @default.
- W2590568180 cites W2020186650 @default.
- W2590568180 cites W2024442574 @default.
- W2590568180 cites W2033365137 @default.
- W2590568180 cites W2050871084 @default.
- W2590568180 cites W2052343947 @default.
- W2590568180 cites W2060788447 @default.
- W2590568180 cites W2064774527 @default.
- W2590568180 cites W2068607701 @default.
- W2590568180 cites W2071957969 @default.
- W2590568180 cites W2073488873 @default.
- W2590568180 cites W2074740617 @default.
- W2590568180 cites W2077232409 @default.
- W2590568180 cites W2080454444 @default.
- W2590568180 cites W2082423227 @default.
- W2590568180 cites W2093000032 @default.
- W2590568180 cites W2098627436 @default.
- W2590568180 cites W2099504481 @default.
- W2590568180 cites W2100191068 @default.
- W2590568180 cites W2101889720 @default.
- W2590568180 cites W2110094509 @default.
- W2590568180 cites W2132740981 @default.
- W2590568180 cites W2134955152 @default.
- W2590568180 cites W2136217341 @default.
- W2590568180 cites W2142935596 @default.
- W2590568180 cites W2161195607 @default.
- W2590568180 cites W2161210875 @default.
- W2590568180 cites W2413825991 @default.
- W2590568180 cites W2582282148 @default.
- W2590568180 cites W2583347981 @default.
- W2590568180 cites W4211129290 @default.
- W2590568180 cites W815604314 @default.
- W2590568180 doi "https://doi.org/10.1016/j.virol.2017.02.019" @default.
- W2590568180 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28242514" @default.
- W2590568180 hasPublicationYear "2017" @default.
- W2590568180 type Work @default.
- W2590568180 sameAs 2590568180 @default.
- W2590568180 citedByCount "9" @default.
- W2590568180 countsByYear W25905681802018 @default.
- W2590568180 countsByYear W25905681802019 @default.
- W2590568180 countsByYear W25905681802021 @default.
- W2590568180 countsByYear W25905681802022 @default.
- W2590568180 countsByYear W25905681802023 @default.
- W2590568180 crossrefType "journal-article" @default.
- W2590568180 hasAuthorship W2590568180A5032778910 @default.
- W2590568180 hasAuthorship W2590568180A5066254776 @default.
- W2590568180 hasConcept C104317684 @default.
- W2590568180 hasConcept C121332964 @default.
- W2590568180 hasConcept C12554922 @default.
- W2590568180 hasConcept C143065580 @default.
- W2590568180 hasConcept C16318435 @default.
- W2590568180 hasConcept C176944494 @default.
- W2590568180 hasConcept C2776441376 @default.
- W2590568180 hasConcept C54355233 @default.
- W2590568180 hasConcept C547475151 @default.
- W2590568180 hasConcept C552990157 @default.
- W2590568180 hasConcept C62520636 @default.
- W2590568180 hasConcept C86803240 @default.
- W2590568180 hasConcept C89611455 @default.
- W2590568180 hasConcept C95444343 @default.
- W2590568180 hasConceptScore W2590568180C104317684 @default.
- W2590568180 hasConceptScore W2590568180C121332964 @default.
- W2590568180 hasConceptScore W2590568180C12554922 @default.
- W2590568180 hasConceptScore W2590568180C143065580 @default.
- W2590568180 hasConceptScore W2590568180C16318435 @default.
- W2590568180 hasConceptScore W2590568180C176944494 @default.
- W2590568180 hasConceptScore W2590568180C2776441376 @default.
- W2590568180 hasConceptScore W2590568180C54355233 @default.
- W2590568180 hasConceptScore W2590568180C547475151 @default.
- W2590568180 hasConceptScore W2590568180C552990157 @default.
- W2590568180 hasConceptScore W2590568180C62520636 @default.
- W2590568180 hasConceptScore W2590568180C86803240 @default.
- W2590568180 hasConceptScore W2590568180C89611455 @default.
- W2590568180 hasConceptScore W2590568180C95444343 @default.
- W2590568180 hasLocation W25905681801 @default.
- W2590568180 hasLocation W25905681802 @default.
- W2590568180 hasOpenAccess W2590568180 @default.
- W2590568180 hasPrimaryLocation W25905681801 @default.
- W2590568180 hasRelatedWork W1530845363 @default.
- W2590568180 hasRelatedWork W188926022 @default.
- W2590568180 hasRelatedWork W1913380961 @default.
- W2590568180 hasRelatedWork W2009647017 @default.
- W2590568180 hasRelatedWork W2024943497 @default.