Matches in SemOpenAlex for { <https://semopenalex.org/work/W2590573757> ?p ?o ?g. }
- W2590573757 endingPage "2099" @default.
- W2590573757 startingPage "2089" @default.
- W2590573757 abstract "With the aim of evaluating anticancerous activities of 10-gingerol (10-G) against HeLa cells, it was purified and identified from “Tongling white ginger” by HSCCC, UPLC-TOF-MS/MS, and NMR analysis, respectively. 10-G inhibited the proliferation of HeLa cells at IC50 (29.19 μM) and IC80 (50.87 μM) with altered cell morphology, increased cytotoxicity, and arrested cell cycle in the G0/G1 phase. Most cell cycle related genes and protein expression significantly decreased, followed by a slight decrease in a few without affecting cyclin B1 and cyclin E1 (protein). Both death receptors significantly up-regulated and activated apoptosis indicators (caspase family). Furthermore, significant changes in mitochondria-dependent pathway markers were observed and led to cell death. 10-G led to PI3K/AKT inhibition and AMPK activation to induce mTOR-mediated cell apoptosis in HeLa cells. These results can be an asset to exploit 10-G with other medicinal plant derivatives for future applications." @default.
- W2590573757 created "2017-03-03" @default.
- W2590573757 creator A5003683850 @default.
- W2590573757 creator A5030908494 @default.
- W2590573757 creator A5051896119 @default.
- W2590573757 creator A5061811158 @default.
- W2590573757 creator A5090818171 @default.
- W2590573757 date "2017-03-01" @default.
- W2590573757 modified "2023-10-17" @default.
- W2590573757 title "10-Gingerol, a Phytochemical Derivative from “Tongling White Ginger”, Inhibits Cervical Cancer: Insights into the Molecular Mechanism and Inhibitory Targets" @default.
- W2590573757 cites W1024036315 @default.
- W2590573757 cites W1970961751 @default.
- W2590573757 cites W1971342909 @default.
- W2590573757 cites W1976404058 @default.
- W2590573757 cites W1986627544 @default.
- W2590573757 cites W1988210441 @default.
- W2590573757 cites W1996877920 @default.
- W2590573757 cites W1996931025 @default.
- W2590573757 cites W1999074825 @default.
- W2590573757 cites W2009126197 @default.
- W2590573757 cites W2020313062 @default.
- W2590573757 cites W2023953169 @default.
- W2590573757 cites W2025336062 @default.
- W2590573757 cites W2031412953 @default.
- W2590573757 cites W2034991912 @default.
- W2590573757 cites W2036162401 @default.
- W2590573757 cites W2052226480 @default.
- W2590573757 cites W2056564326 @default.
- W2590573757 cites W2058443165 @default.
- W2590573757 cites W2060864994 @default.
- W2590573757 cites W2080844942 @default.
- W2590573757 cites W2084149807 @default.
- W2590573757 cites W2111114352 @default.
- W2590573757 cites W2121629705 @default.
- W2590573757 cites W2121966499 @default.
- W2590573757 cites W2124926575 @default.
- W2590573757 cites W2125899548 @default.
- W2590573757 cites W2154503158 @default.
- W2590573757 cites W2156179144 @default.
- W2590573757 cites W2169238639 @default.
- W2590573757 cites W2169516198 @default.
- W2590573757 cites W2169972304 @default.
- W2590573757 cites W2171010297 @default.
- W2590573757 cites W2176436851 @default.
- W2590573757 cites W2314692506 @default.
- W2590573757 cites W2515437976 @default.
- W2590573757 cites W2518161790 @default.
- W2590573757 cites W2520339205 @default.
- W2590573757 cites W2533485533 @default.
- W2590573757 cites W2563899448 @default.
- W2590573757 doi "https://doi.org/10.1021/acs.jafc.7b00095" @default.
- W2590573757 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28230361" @default.
- W2590573757 hasPublicationYear "2017" @default.
- W2590573757 type Work @default.
- W2590573757 sameAs 2590573757 @default.
- W2590573757 citedByCount "55" @default.
- W2590573757 countsByYear W25905737572017 @default.
- W2590573757 countsByYear W25905737572018 @default.
- W2590573757 countsByYear W25905737572019 @default.
- W2590573757 countsByYear W25905737572020 @default.
- W2590573757 countsByYear W25905737572021 @default.
- W2590573757 countsByYear W25905737572022 @default.
- W2590573757 countsByYear W25905737572023 @default.
- W2590573757 crossrefType "journal-article" @default.
- W2590573757 hasAuthorship W2590573757A5003683850 @default.
- W2590573757 hasAuthorship W2590573757A5030908494 @default.
- W2590573757 hasAuthorship W2590573757A5051896119 @default.
- W2590573757 hasAuthorship W2590573757A5061811158 @default.
- W2590573757 hasAuthorship W2590573757A5090818171 @default.
- W2590573757 hasConcept C105696609 @default.
- W2590573757 hasConcept C120504264 @default.
- W2590573757 hasConcept C1491633281 @default.
- W2590573757 hasConcept C184235292 @default.
- W2590573757 hasConcept C185592680 @default.
- W2590573757 hasConcept C190283241 @default.
- W2590573757 hasConcept C2777366897 @default.
- W2590573757 hasConcept C2778437423 @default.
- W2590573757 hasConcept C2780124434 @default.
- W2590573757 hasConcept C29537977 @default.
- W2590573757 hasConcept C31573885 @default.
- W2590573757 hasConcept C55493867 @default.
- W2590573757 hasConcept C62112901 @default.
- W2590573757 hasConcept C75217442 @default.
- W2590573757 hasConcept C86554907 @default.
- W2590573757 hasConcept C86803240 @default.
- W2590573757 hasConcept C95444343 @default.
- W2590573757 hasConcept C97029542 @default.
- W2590573757 hasConceptScore W2590573757C105696609 @default.
- W2590573757 hasConceptScore W2590573757C120504264 @default.
- W2590573757 hasConceptScore W2590573757C1491633281 @default.
- W2590573757 hasConceptScore W2590573757C184235292 @default.
- W2590573757 hasConceptScore W2590573757C185592680 @default.
- W2590573757 hasConceptScore W2590573757C190283241 @default.
- W2590573757 hasConceptScore W2590573757C2777366897 @default.
- W2590573757 hasConceptScore W2590573757C2778437423 @default.
- W2590573757 hasConceptScore W2590573757C2780124434 @default.
- W2590573757 hasConceptScore W2590573757C29537977 @default.
- W2590573757 hasConceptScore W2590573757C31573885 @default.