Matches in SemOpenAlex for { <https://semopenalex.org/work/W2590596325> ?p ?o ?g. }
- W2590596325 endingPage "16" @default.
- W2590596325 startingPage "1" @default.
- W2590596325 abstract "Diabetes in whites of European descent with hemochromatosis was first attributed to pancreatic siderosis. Later observations revealed that the pathogenesis of diabetes in HFE hemochromatosis is multifactorial and its clinical manifestations are heterogeneous. Increased type 2 diabetes risk in HFE hemochromatosis is associated with one or more factors, including abnormal iron homeostasis and iron overload, decreased insulin secretion, cirrhosis, diabetes in first-degree relatives, increased body mass index, insulin resistance, and metabolic syndrome. In p.C282Y homozygotes, serum ferritin, usually elevated at hemochromatosis diagnosis, largely reflects body iron stores but not diabetes risk. In persons with diabetes type 2 without hemochromatosis diagnoses, serum ferritin levels are higher than those of persons without diabetes, but most values are within the reference range. Phlebotomy therapy to achieve iron depletion does not improve diabetes control in all persons with HFE hemochromatosis. The prevalence of type 2 diabetes diagnosed today in whites of European descent with and without HFE hemochromatosis is similar. Routine iron phenotyping or HFE genotyping of patients with type 2 diabetes is not recommended. Herein, we review diabetes in HFE hemochromatosis and the role of iron in diabetes pathogenesis in whites of European descent with and without HFE hemochromatosis." @default.
- W2590596325 created "2017-03-03" @default.
- W2590596325 creator A5077060961 @default.
- W2590596325 creator A5086327516 @default.
- W2590596325 date "2017-01-01" @default.
- W2590596325 modified "2023-10-17" @default.
- W2590596325 title "Diabetes in<i>HFE</i>Hemochromatosis" @default.
- W2590596325 cites W1156072596 @default.
- W2590596325 cites W1184468117 @default.
- W2590596325 cites W1499734199 @default.
- W2590596325 cites W1502690419 @default.
- W2590596325 cites W1510134239 @default.
- W2590596325 cites W1516997487 @default.
- W2590596325 cites W1564878813 @default.
- W2590596325 cites W1595371397 @default.
- W2590596325 cites W1627887482 @default.
- W2590596325 cites W179465749 @default.
- W2590596325 cites W1911334544 @default.
- W2590596325 cites W1918830284 @default.
- W2590596325 cites W1923862574 @default.
- W2590596325 cites W192955503 @default.
- W2590596325 cites W1957651862 @default.
- W2590596325 cites W1962027081 @default.
- W2590596325 cites W1970022759 @default.
- W2590596325 cites W1970502187 @default.
- W2590596325 cites W1972453020 @default.
- W2590596325 cites W1974892673 @default.
- W2590596325 cites W1975177708 @default.
- W2590596325 cites W1976910163 @default.
- W2590596325 cites W1979019761 @default.
- W2590596325 cites W1985600975 @default.
- W2590596325 cites W1985864332 @default.
- W2590596325 cites W1985984928 @default.
- W2590596325 cites W1986840089 @default.
- W2590596325 cites W1987046928 @default.
- W2590596325 cites W1987922858 @default.
- W2590596325 cites W1990868065 @default.
- W2590596325 cites W1991043124 @default.
- W2590596325 cites W1995410840 @default.
- W2590596325 cites W1996648045 @default.
- W2590596325 cites W1997462858 @default.
- W2590596325 cites W1998872310 @default.
- W2590596325 cites W2001382654 @default.
- W2590596325 cites W2001777392 @default.
- W2590596325 cites W2002605005 @default.
- W2590596325 cites W2002949600 @default.
- W2590596325 cites W2005316756 @default.
- W2590596325 cites W2005620802 @default.
- W2590596325 cites W2006659425 @default.
- W2590596325 cites W2008818072 @default.
- W2590596325 cites W2008855976 @default.
- W2590596325 cites W2009123354 @default.
- W2590596325 cites W2010100852 @default.
- W2590596325 cites W2010205820 @default.
- W2590596325 cites W2011007951 @default.
- W2590596325 cites W2012343068 @default.
- W2590596325 cites W2012852339 @default.
- W2590596325 cites W2013566167 @default.
- W2590596325 cites W2013966444 @default.
- W2590596325 cites W2017207954 @default.
- W2590596325 cites W2017373539 @default.
- W2590596325 cites W2017722157 @default.
- W2590596325 cites W2018020365 @default.
- W2590596325 cites W2019950427 @default.
- W2590596325 cites W2020932850 @default.
- W2590596325 cites W2021305306 @default.
- W2590596325 cites W2023981089 @default.
- W2590596325 cites W2024108088 @default.
- W2590596325 cites W2025332231 @default.
- W2590596325 cites W2025756144 @default.
- W2590596325 cites W2026203736 @default.
- W2590596325 cites W2027305568 @default.
- W2590596325 cites W2028034405 @default.
- W2590596325 cites W2029065794 @default.
- W2590596325 cites W2029828243 @default.
- W2590596325 cites W2030040725 @default.
- W2590596325 cites W2031041060 @default.
- W2590596325 cites W2032542021 @default.
- W2590596325 cites W2033831432 @default.
- W2590596325 cites W2034587996 @default.
- W2590596325 cites W2036156503 @default.
- W2590596325 cites W2036480533 @default.
- W2590596325 cites W2038944724 @default.
- W2590596325 cites W2040866935 @default.
- W2590596325 cites W2040957926 @default.
- W2590596325 cites W2043302398 @default.
- W2590596325 cites W2045017910 @default.
- W2590596325 cites W2045242418 @default.
- W2590596325 cites W2047812782 @default.
- W2590596325 cites W2049416980 @default.
- W2590596325 cites W2050328770 @default.
- W2590596325 cites W2051778940 @default.
- W2590596325 cites W2052257773 @default.
- W2590596325 cites W2052366375 @default.
- W2590596325 cites W2052526643 @default.
- W2590596325 cites W2053430176 @default.
- W2590596325 cites W2057265205 @default.
- W2590596325 cites W2057623608 @default.