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• W2590599210 abstract "// Maya Jeitany 1, 2, 3, 4, * , Dalal Bakhos-Douaihy 1, 2, 3, 4, * , David C. Silvestre 1, 2, 3, 4 , Jose R. Pineda 1, 2, 3, 4 , Nicolas Ugolin 5 , Angela Moussa 1, 2, 3, 4 , Laurent R. Gauthier 1, 2, 3, 4 , Didier Busso 2, 6 , Marie-Pierre Junier 7, 8, 9, * , Hervé Chneiweiss 7, 8, 9, * , Sylvie Chevillard 5 , Chantal Desmaze 1, 2, 3, 4 , François D. Boussin 1, 2, 3, 4 1 Laboratoire de Radiopathologie, CEA, Institut de Radiobiologie Cellulaire et Moléculaire, Fontenay-aux-Roses, France 2 INSERM UMR967, Fontenay-aux-Roses, France 3 Université Paris VII, UMR967, Fontenay-aux-Roses, France 4 Université Paris XI, UMR967, Fontenay-aux-Roses, France 5 Laboratoire de Cancérologie Expérimentale, iRCM, DSV, CEA, Fontenay-aux-Roses, France 6 CIGEx, IRCM, Fontenay-aux-Roses, France 7 CNRS UMR8246 Neuroscience Paris Seine-IBPS, Team Glial Plasticity, Paris, France 8 Inserm U1130, Neuroscience Paris Seine-IBPS, Team Glial Plasticity, Paris, France 9 University Pierre and Marie Curie UMCR18, Neuroscience Paris Seine-IBPS, Team Glial Plasticity, Paris, France * These authors contributed equally to this work Correspondence to: François D. Boussin, email: boussin@cea.fr Maya Jeitany, email: maya_jjy@hotmail.com Keywords: PCAF, GCN5, telomere recombination, ALT Received: June 07, 2016      Accepted: February 06, 2017      Published: February 17, 2017 ABSTRACT Cancer cells can use a telomerase-independent mechanism, known as alternative lengthening of telomeres (ALT), to elongate their telomeres. General control non-derepressible 5 (GCN5) and P300/CBP-associated factor (PCAF) are two homologous acetyltransferases that are mutually exclusive subunits in SAGA-like complexes. Here, we reveal that down regulation of GCN5 and PCAF had differential effects on some phenotypic characteristics of ALT cells. Our results suggest that GCN5 is present at telomeres and opposes telomere recombination, in contrast to PCAF that may indirectly favour them in ALT cells." @default.
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• W2590599210 date "2017-02-17" @default.
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• W2590599210 title "Opposite effects of GCN5 and PCAF knockdowns on the alternative mechanism of telomere maintenance" @default.
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• W2590599210 doi "https://doi.org/10.18632/oncotarget.15447" @default.
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